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The effects of enterostatin intake on food intake and energy expenditure

Published online by Cambridge University Press:  07 June 2007

Eva M. R. Kovacs ,
Manuela P. G. M. Lejeune  and
Margriet S. Westerterp-Plantenga
Eva M. R. Kovacs*
Affiliation:
Department of Human Biology, Maastricht University, Maastricht, The Netherlands
Manuela P. G. M. Lejeune
Affiliation:
Department of Human Biology, Maastricht University, Maastricht, The Netherlands
Margriet S. Westerterp-Plantenga
Affiliation:
Department of Human Biology, Maastricht University, Maastricht, The Netherlands
*
*Corresponding author: Dr Eva M. R. Kovacs, fax +31 10 460 57 26, email [email protected]
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Abstract

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Enterostatin (ENT) has been found to inhibit food intake and selectively inhibit fat intake in rats. Both peripheral and central mechanisms have been proposed. It also has been suggested that ENT may increase thermogenesis. The present study investigated the effects of oral ENT administration on food intake, energy expenditure and body weight in subjects with a preference for a high-fat diet. In a double-blind, placebo-controlled, randomized and crossover design, nine female and three male healthy subjects (age 34 (sd 11) years, BMI 24·5 (sd 2·5) kg/m2) with a preference for a high-fat diet ingested ENT (3 × 15 mg/d) or placebo (PLA) while consuming a high-fat diet ad libitum for 4d. Eight subjects ended each intervention with a 36h stay in the respiration chamber, continuing the diet and treatment. Body-weight loss was significant (ENT 0·8 (se 0·3) kg, P<0·05; PLA 1·3 (se 0·3) kg, P<0·001), but not different between treatments. There was no difference between treatments in total energy intake (ENT 37·1 (se 2·6), PLA 35·9 (se 3·2) MJ), macronutrient composition, hunger, satiety and hedonic scores during the 4d high-fat diet. Energy expenditure (24h) (ENT 9·6 (se 0·4), PLA 9·5 (se 0·4) MJ), sleeping and resting metabolic rate, diet-induced thermogenesis, activity-induced energy expenditure and 24h RQ (ENT 0·77 (se 0·01), PLA 0·77 (se 0·01)) were similar for both treatments. We conclude that oral ENT administration did not affect food intake, energy expenditure or body weight in subjects with a preference for a high-fat diet experiencing a negative energy and fat balance.

Keywords

Energy intakeFat intakeEnergy expenditureBody weightFat preference
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 1 , July 2003 , pp. 207 - 214
Copyright
Copyright © The Nutrition Society 2003

References

Bowyer, RC, Rowston, WM, Jehanli, AMT, Lacey, JH & Hermon-Taylor, J (1993) The effect of satiating meal on the concentrations of procolipase activation peptide in the serum and urine of normal and morbidity obese individuals. Gut 34, 1520–1525.CrossRefGoogle Scholar
Bray, GA (2000) Afferent signals regulating food intake. Proc Nutr Soc 59, 373–384.CrossRefGoogle ScholarPubMed
Brouwer, E (1957) On simple formulae for calculating the heat expenditure and the quantities of carbohydrate and fat oxidised in metabolism of men and animals, from gaseous exchange (oxygen intake and carbonic output) and urine-N. Acta Physiol Pharmacol N 6, 795–802.Google ScholarPubMed
Erlanson-Albertsson, C, Mei, J, Okada, S, York, D & Bray, GA (1991) Pancreatic procolipase propeptide, enterostatin, specifically inhibits fat intake. Physiol Behav 49, 1191–1194.CrossRefGoogle ScholarPubMed
Erlanson-Albertsson, C & York, D (1997) Enterostatin – A peptide regulating fat intake. Obes Res 5, 360–372.CrossRefGoogle ScholarPubMed
Harris, JA & Benedict, FG (1919) In A Biometric Study of Basal Metabolism in Man. Washington: Carnegie Institution.Google Scholar
Herman, CP & Polivy, J (1980) Restrained eating. In Obesity. pp 208–225. [Stunkard, AJ, editor]. Philadelphia: W. B. Saunders.Google Scholar
Jas, PE (1996) Changes in food intake and mood across the menstrual cycle. PhD Thesis, University of Reading.Google Scholar
Lin, L, Chen, J & York, DA (1997) Chronic icv enterostatin preferentially reduced fat intake and lowered body weight. Peptides 18, 657–661.CrossRefGoogle ScholarPubMed
Lin, L & York, DA (1994) Metergoline blocks the feeding response to enterostatin. Appetite 23, 313 Abstr.Google Scholar
Lin, L & York, DA (1998) Chronic ingestion of dietary fat is a prerequisite for inhibition of feeding by enterostatin. Am J Physiol 275, R619–R623.Google ScholarPubMed
Lorr, M & McNair, DM (1984) Manual. Prile Mood States. Bi-Polar Form (POMS-BI). San Diego, CA: Educational and Industrial Testing Service (EDITS).Google Scholar
Mei, J, Cheng, Y & Erlanson-Albertsson, C (1993) Enterostatin – its ability to inhibit insulin secretion and to decrease high-fat food intake. Int J Obes Relat Metabol Disord 17, 701–704.Google ScholarPubMed
Mei, J & Erlanson-Albertsson, C (1996) Plasma insulin response to enterostatin and effect of adrenalectomy in rat. Obes Res 4, 513–519.CrossRefGoogle Scholar
Nagase, H, Bray, GA & York, DA (1997) Effect of galanin and enterostatin on sympathetic nerve activity to interscapular brown adipose tissue. Brain Res 709, 44–50.CrossRefGoogle Scholar
Okada, S, York, DA, Bray, GA & Erlanson-Albertsson, C (1991) Enterostatin (Val–Pro–Asp–Pro–Arg) the activation peptide of procolipase selectively reduces fat intake. Physiol Behav 49, 1185–1189.CrossRefGoogle ScholarPubMed
Okada, S, York, DA, Bray, GA, Mei, J & Erlanson-Albertsson, C (1992) Differential inhibition of fat intake in two strains of rat by the peptide enterostatin. Am J Clin Nutr 262, R1111–R1116.Google ScholarPubMed
Okada, S, Lin, L, York, DA & Bray, GA (1993) Chronic effects of intracerebral ventricular enterostatin in Osborne-Mendel rats fed a high-fat diet. Physiol Behav 54, 325–330.CrossRefGoogle ScholarPubMed
Ookuma, KC, Barton, C, York, DA & Bray, GA (1997) Effect of enterostatin and kappa-opioids on macronutrient selection and consumption. Peptides 18, 785–791.CrossRefGoogle ScholarPubMed
Prasad, C, Imamura, M, Debata, C, Svec, F, Sumar, N & Hermon-Taylor, J (1999) Hyperenterostatinemia in premenopausal obese women. J Clin Endocrinol Metabol 84, 937–941.Google ScholarPubMed
Rössner, S, Barkeling, B, Erlanson-Albertsson, C, Larsson, P & Wahlin-Boll, E (1995) Intravenous enterostatin does not affect single meal food intake in man. Appetite 24, 37–42.CrossRefGoogle Scholar
Rozin, P, Levine, E & Stoess, C (1991) Chocolate craving and liking. Appetite 17, 199–212.CrossRefGoogle ScholarPubMed
Schoffelen, PFM, Westerterp, KR, Saris, WHM & ten Hoor, F (1997) A dual respiration chamber with automated calibration. J Appl Physiol 83, 2064–2072.CrossRefGoogle ScholarPubMed
Schrauwen, P, Marken Lichtenbelt van, WD, Saris, WHM & Westerterp, KR (1997) Changes in nutrient oxidation in response to a high-fat diet. Am J Clin Nutr 66, 276–282.CrossRefGoogle Scholar
Schutz, Y (1995) Macronutrients and energy balance in obesity. Metabolism 44(Suppl.), 7–11.CrossRefGoogle ScholarPubMed
Smeets, M, Geiselman, P, Bray, GA & York, DA (1999) The effect of oral enterostatin on hunger and food intake in human volunteers. FASEB J 13, A871 Abstr.Google Scholar
Sörhede, M, Mei, J & Erlanson-Albertsson, C (1993) Enterostatin – a gut-brain peptide – regulating fat intake in rat. J Physiol Paris 87, 273–275.CrossRefGoogle ScholarPubMed
Stichting Nederlands Voedingsstoffenbestand (1996) Nevo Tabel (New Tables). Den Haag: Voorlichtingsbureau voor de voeding.Google Scholar
Stunkard, AJ & Messick, S (1985) The three-factor eating questionnaire to measure dietary restraint, disinhibition, and hunger. J Psychosom Res 29, 71–83.CrossRefGoogle ScholarPubMed
Swinburn, BA & Ravusssin, E (1993) Energy balance or fat balance?. Am J Clin Nutr 57(Suppl.), 766S–770S.CrossRefGoogle ScholarPubMed
Tarasuk, V & Beaton, GH (1991) Menstrual-cycle patterns in energy and macronutrient intake. Am J Clin Nutr 53, 442–447.CrossRefGoogle ScholarPubMed
Tian, Q, Nagase, H, York, DA & Bray, GA (1994) Vagal-central nervous system interactions modulate the feeding response to peripheral enterostatin. Obes Res 2, 527–534.CrossRefGoogle ScholarPubMed
Tomelleri, R & Grunewald, K (1987) Menstrual cycle and food cravings in young college women. J Am Med Assoc 87, 829–837.Google ScholarPubMed
Weir, JBdeV (1949) New methods for calculating metabolic rate with special references to protein metabolism. J Physiol 109, 1–9.CrossRefGoogle ScholarPubMed
Westerterp, KR, Wilson, SAJ & Rolland, V (1998) Diet induced thermogenesis measured over 24h in a respiration chamber:effect of diet composition. Int J Obes Relat Metabol Disord 22, 1–6.Google Scholar
Westerterp-Plantenga, MS, Rolland, V, Wilson, SAJ & Westerterp, KR (1999) Satiety related to 24h diet-induced thermogenesis during high protein/carbohydrate vs high fat diets measured in a respiration chamber. Eur J Clin Nutr 53, 1–8.CrossRefGoogle Scholar