Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-22T23:58:57.806Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of dietary fat content on the growth and body composition of lean and genetically obese Zucker rats adrenalectomized before weaning

Published online by Cambridge University Press:  09 March 2007

J. M. Fletcher  and
N. McKenzie
J. M. Fletcher
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
N. McKenzie
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Lean (Fa/–) and obese (fa/fa) Zucker rats were adrenalectomized or sham-operated at 18 d of age (3 d before weaning). After weaning the rats were fed ad lib. on semi-synthetic diets containing either a low (8 g/kg) or a high (178 g/kg) proportion of fat. Other groups of sham-operated rats were given the same amount eaten by adrenalectomized animals (restricted intake). Rats were killed at 40 d of age.

2. Adrenalectomy reduced the body lipid content of lean and obese rats compared with intact animals fed ad lib. or given a restricted intake. Adrenalectomized obese rats contained more body lipid than intact or adrenalectomized lean rats.

3. Sham-operated obese rats given a restricted intake had less body protein than similarly treated lean animals and this phenotypic difference was abolished by adrenalectomy.

4. There were no effects of diet on growth or body composition of intact or adrenalectomized rats.

5. It is concluded that preweaning adrenalectomy prevented development of the obese phenotype when rats were fed on either diet. Comparison of these results with a previous study, in which adrenalectomized Zucker rats were fed on a stock diet (Fletcher, 1986b), showed, however, that feeding either of the semi-synthetic diets caused greater deposition of body lipid in obese rats.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 60 , Issue 3 , November 1988 , pp. 563 - 569
Copyright
Copyright © The Nutrition Society 1988

References

Atkinson, T., Fowler, V. R., Garton, G. A. & Lough, A. K. (1972) Analyst 97, 562–568.CrossRefGoogle Scholar
Berdanier, C. D., Wurdeman, R. & Tobin, R. D. (1976) Journal of Nutrition 106, 1791–1800.CrossRefGoogle Scholar
Bouillon, D. & Berdanier, C. D. (1980) Journal of Nutrition 110, 286–297.CrossRefGoogle Scholar
Bray, G. A., York, D. A. & Sverdloff, R. S. (1973) Metabolism 22, 435–444.CrossRefGoogle Scholar
Cleary, M. P., Vasselli, J. R. & Greenwood, M. R. C. (1980) American Journal of Physiology 284, E284–E292.Google Scholar
Fletcher, J. M. (1986 a) British Journal of Nutrition 56, 141–151.CrossRefGoogle Scholar
Fletcher, J. M. (1986 b) Biochemical Journal 238, 459–463.CrossRefGoogle Scholar
Fletcher, J. M. (1986 c) Physiology and Behaviour 37, 597–602.CrossRefGoogle Scholar
Freedman, M. R., Horwitz, B. A. & Stern, J. S. (1986) American Journal of Physiology 250, R595–R607.Google Scholar
Godbole, V., York, D. A. & Bloxham, D. B. (1978) Diabetologia 15, 41–44.CrossRefGoogle Scholar
Haggarty, P., Wahle, K. W. J., Reeds, P. J. & Fletcher, J. M. (1987) International Journal of Obesity 11, 41–50.Google Scholar
Huggett, A. St & Nixon, D. A. (1957) Lancet ii, 368–370.CrossRefGoogle Scholar
Kaul, L. & Berdanier, C. D. (1975) Journal of Nutrition 105, 1176–1185.CrossRefGoogle Scholar
Marchington, D., Rothwell, N. J., Stock, M. J. & York, D. A. (1983) Journal of Nutrition 113, 1395–1402.CrossRefGoogle Scholar
Miller, D. S. & Bender, A. E. (1955) British Journal of Nutrition 9, 382–388.CrossRefGoogle Scholar
Pullar, J. D. & Webster, A. J. F. (1974) British Journal of Nutrition 31, 377–392.CrossRefGoogle Scholar
Saito, M. & Bray, G. A. (1984) American Journal of Physiology 246, R20–R25.Google Scholar
Smith, C. K. & Romsos, D. R. (1985) American Journal of Physiology 249, R13–R22.Google Scholar
Yukimura, Y., Bray, G. A. & Wolfson, A. R. (1978) Endocrinology 103, 1924–1928.CrossRefGoogle Scholar
Zomzely, C. R., Asti, R. & Mayer, J. (1959) Science 129, 1546–1547.CrossRefGoogle Scholar