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The effects of dietary calcium and phosphorus on the retention and excretion of lead in rats

Published online by Cambridge University Press:  09 March 2007

J. Quarterman  and
J. N. Morrison
J. Quarterman
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J. N. Morrison
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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1. Rats were given diets containing different amounts of calcium, phosphorus and lead.

2. Pb retention was greatly increased when the diets contained less Ca or P than the minimum estimated requirement of the rat.

3. The release of Pb already incorporated into the skeleton was inhibited by diets low in Ca but was not affected by diets low in P.

4. The retention of Pb given intraperitoneally was not affected by dietary Ca or P.

5. It can be concluded that dietary Ca and P influence the absorption of Pb by the gut and dietary Ca influences the metabolism of Pb in the bone.

6. There were changes in the distribution of Pb among the tissues due to changes of dietary Ca.

7. At low body concentrations, Pb probably affected skeletal growth.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 34 , Issue 3 , November 1975 , pp. 351 - 362
Copyright
Copyright © The Nutrition Society 1975

References

Blaxter, K. L. (1950). J. contp. Path. Ther. 60, 140.Google Scholar
British Medical Journal (1968). Br. med. J. iv, 501.Google Scholar
Burch, H. B. & Siegel, A. L. (1971). Clin. Chem. 17, 1038.Google Scholar
Carrol, K. G., Spinelli, F. R. & Goyer, R. A. (1970). Nature, Lond. 227, 1056.CrossRefGoogle Scholar
de Bruin, (1971). Archs envir. Hlth 23, 249.Google Scholar
Galle, P. & Morel-Marager, L. (1965). Nephron 2, 273.Google Scholar
Gitelman, H. J. (1967). Analyt. Biochem. 18, 521.Google Scholar
Goyer, R. A., May, P., Cates, M. M. & Krigman, M. R. (1970). Lab. Invest. 22, 245.Google Scholar
Haeger-Aronsen, B., Abdulla, M. & Fristedt, B. I. (1971). Archs envir. Hlth 23, 440.Google Scholar
Hernberg, S., Nikkanen, J., Mellin, G. & Lilius, H. (1970). Archs envir. Hlth 21, 140.Google Scholar
Hsu, F. S., Krook, L., Shively, J. N., Duncan, J. R. & Pond, W. G. (1973). Science, N.Y. 181, 447.Google Scholar
Kehoe, R. A. (1961). Jl R. Inst. publ. Hlth Hyg. 24, 101.Google Scholar
Kostial, K., Sˇimonovic´, I. & Pisˇonic´, M. (1971). Envir. Res. 4, 360.Google Scholar
Kubasik, N. P., Volosin, M. R. & Murray, M. N. (1972). Clin. Chem. 18, 410.Google Scholar
Laflamme, G. H. & Jowsey, J. (1972). J. clin. Invest. 51, 2834.Google Scholar
Lederer, L. G. & Bing, F. C. (1940). J. Am. med. Ass. 114, 2457.Google Scholar
Mahaffey, K. M., Goyer, R. & Haseman, J. K. (1973). J. Lab. clin. Med. 82, 92.Google Scholar
Morrison, J. N., Quarterman, J. & Humphries, W. R. (1974). Proc. Nutr. Soc. 33, 88A.Google Scholar
National Research Council (1972). Nutrient Requirements of Laboratory Animals, 2nd ed.Washington, DC: Nationsl Research Council.Google Scholar
Nicholas, J. W. (1951). Biochem. J. 50, 1.Google Scholar
Quarterman, J., Morrison, J. N. & Carey, L. F. (1974). In Trace Substances in Environmental Health, vol. 7, p. 347 [Hemphill, D.D. editor]. Columbia, Missouri: University of Missouri.Google Scholar
Roach, A. G. (1965). In Automation in Analytical Chemistry, p. 137 [Skeggs, L.T. editor]. New York: Mediad Inc.Google Scholar
Schroeder, H. A. & Tipton, I. H. (1968). Archs envir. Hlth 17, 965.Google Scholar
Scott, K. M., Hwang, K. M., Jurkowitz, M. & Brierley, G. P. (1971). Archs Biochem. Biophys. 147, 557.CrossRefGoogle Scholar
Shields, J. B. & Mitchell, H. H. (1940). J. Nutr. 21, 541.Google Scholar
Six, K. M. & Goyer, R. A. (1970). J. Lab. clin. Med. 76, 933.Google Scholar
Six, K. M. & Goyer, R. A. (1972). J. Lab. clin. Med. 79, 128.Google Scholar
Sobel, A. E. & Burger, M. (1955). J. biol. Chem. 212, 105.Google Scholar
Sobel, A. E., Yuska, H., Peters, D. D. & Kramer, B. (1940). J. biol. Chem. 132, 239.Google Scholar
Wasserman, R. H. & Corradino, R. A. (1973). Vitams Horm. 31, 43.CrossRefGoogle Scholar
WHO (1972). Tech. Rep. Ser. Wld Hlth Org. no. 505.Google Scholar
Willoughby, R. A., MacDonald, E., McSherry, B. J. & Brown, G. (1972). Can. J. comp. Med. 36, 348.Google Scholar
Willoughby, R. A., Thirapatsakun, T. & McSherry, B. J. (1972). Am. J. vet. Res. 33, 1165.Google Scholar
Young, D. S. (1966). J. clin. Path. 19, 397.Google Scholar