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The effects of dietary acid stress on bone metabolism in young ovariectomized and intact rats

Published online by Cambridge University Press:  09 March 2007

M. E. kunkel ,
Z. K. Roughead ,
E. A. Nichter  and
J. M. Navia
M. E. kunkel
Affiliation:
Depurtment of Food Science, Clemson University, Clemson, SC 29631, USA
Z. K. Roughead
Affiliation:
Depurtment of Food Science, Clemson University, Clemson, SC 29631, USA
E. A. Nichter
Affiliation:
Depurtment of Food Science, Clemson University, Clemson, SC 29631, USA
J. M. Navia
Affiliation:
Depurtment of Food Science, Clemson University, Clemson, SC 29631, USA
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Abstract

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1. Two studies were performed to determine the effects of acid stress and ovariectomy on bone metabolism in young rats. In Expt 1, eighteen female weanling Sprague-Dawley-descended rats were ovariectomized, placed in one of three dietary groups and given a diet containing (g/kg): 6 calcium and 3, 6 or 12 phosphorus for 10 weeks. In Expt 2, thirty-two female weanling Sprague-Dawley-descended rats were ovariectomized, and thirty-two were left intact. Eight rats from each group were given a diet containing (g/kg): 6 Ca and 3 P, 12 P, 3 P+1 S or 3 P+20 ammonium chloride for 10 weeks.

2. Feeding diets containing 12 g P/kg resulted in decreased serum Ca and increased urinary P with no changes in femur composition. Feeding high-sulphate and ammonium chloride diets resulted in increased urinary Ca and, when combined with ovariectomy, lower femur Ca and P with no changes in femur hydroxyproline or hexosamines.

3. The findings reflect the more rapid turnover of the amorphous calcium phosphate salts found in greater amounts in bones of younger animals than for more stable apatitic crystals that predominate in bones of older animals.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 1 , January 1986 , pp. 79 - 86
Copyright
Copyright © The Nutrition Society 1986

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