Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-05T08:52:03.643Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of ascorbic acid on the skeletal response of chicks to vitamin D deficiency*

Published online by Cambridge University Press:  09 March 2007

P. A. Thornton
P. A. Thornton
Affiliation:
Veterans Administration Hospital, Lexington, Kentucky, Departments of Physiology and Biophysics and of Medicine, University of Kentucky, Lexington, Kentucky, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The skeletal response of vitamin D-deficient chicks to dietary ascorbic acid was tested.

2. The epiphyseal cartilaginous plate width, which was increased by the vitamin D deficiency, was further increased when ascorbic acid was added and the effect appeared sooner.

3. Absence of vitamin D was associated with a reduction in the relative amount of cancellous to compact bone ash in the tibia. Dietary ascorbic acid intensified this effect to a significant degree.

4. Plasma ascorbic acid levels in rachitic chicks were approximately 25% less than in controls. This observation may explain the skeletal response to added vitamin C and suggests that avian bone tissue has a particularly high requirement for this vitamin.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 1 , February 1968 , pp. 77 - 82
Copyright
Copyright © The Nutrition Society 1968

References

Au, W. Y. W. & Raisz, L. G. (1965). Am. J. Physiol. 209, 637.CrossRefGoogle Scholar
Bauer, W., Aub, J. C. & Albright, F. (1929). J. exp. Med. 49, 145.CrossRefGoogle Scholar
Bourne, G. H. (1956). The Biochemistry and Physiology of Bone. New York: Academic Press Inc.Google Scholar
Briggs, G. M., Combs, G. F., Friedman, L., Fritz, J. C.Lillie, R. J., Nelson, J. W., Quackenbush, F. W. & Titus, H. W. (1956). Feed Age, May issue.Google Scholar
Hunter, D. & Aub, J. C. (1927). Q. Jl Med. 20, 123.Google Scholar
Martin, C. J. & Axelrod, A. E. (1953). Proc. Soc. exp. Biol. Med. 83, 461.CrossRefGoogle Scholar
Natelson, S., Pincus, J. B. & Lugovoy, J. K. (1948). J. biol. Chem. 175, 745.Google Scholar
Neuman, W. F. & Neuman, M. W. (1958). The Chemical Dynamics of Bone Mineral. Chicago: University of Chicago Press.Google Scholar
Roe, J. H. & Kuether, C. A. (1943). J. biol. Chem. 147, 399.CrossRefGoogle Scholar
Thornton, P. A. & Brownrigg, D. (1961). J. Nutr. 75, 354.Google Scholar
Thornton, P. A., Weber, C. W. & Moreng, R. E. (1959). J. Nutr. 69, 33.CrossRefGoogle Scholar
Todhunter, E. N. & McMillan, T. J. (1946). J. Nutr. 31, 573.CrossRefGoogle Scholar