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Effects of aliphatic dioic acids and glycerol-1,2,3-tris(dodecanedioate) on D-glucose-stimulated insulin release in rat pancreatic islets

Published online by Cambridge University Press:  09 March 2007

W. J. Malaisse ,
A. V. Greco  and
G. Mingrone
W. J. Malaisse*
Affiliation:
Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
A. V. Greco
Affiliation:
Instituto de Clinica Medica, Universita Cattolica del Sacro Cuore, Rome, Italy
G. Mingrone
Affiliation:
Instituto de Clinica Medica, Universita Cattolica del Sacro Cuore, Rome, Italy
*
*Corresponding author: Professor W. J. Malaisse, fax +32 2 555 62 39, email [email protected]
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Abstract

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Aliphatic dioic acids have been proposed as alternative nutrients in selected clinical situations. In this study, their possible insulinotropic action was investigated in isolated rat pancreatic islets prepared from fed rats. Azelaic acid, sebacic acid and tridecanedioic acids, when tested at a 10·0 mM CONCENTRATION, WERE FOUND TO AUGMENT INSULIN RELEASE EVOKED BY d-glucose (7·0 mm) in the pancreatic islets. Likewise, glycerol-1,2,3-tris(dodecanoedioate), when used at concentrations close to 1·0 mm, increased the secretory response to the hexose. It is speculated that these findings may extend to insulin-producing cells, the knowledge that aliphatic dioic acids or their esters may act as energy substrates, e.g. in parenteral nutrition.

Keywords

Pancreatic isletsInsulin secretionAliphatic dioic acids
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 733 - 736
Copyright
Copyright © The Nutrition Society 2000

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