Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-26T08:07:46.388Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of vitamin A deficiency and Newcastle disease virus infection on IgA and IgM secretion in chickens

Published online by Cambridge University Press:  09 March 2007

Jan H. W. M. Rombout ,
S. Reinder Sijtsma ,
Clive E. West ,
Yannoula Karabinis ,
Oscar K. W. Sijtsma ,
Akke J. Van Der Zijpp  and
Guus Koch
Jan H. W. M. Rombout
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
S. Reinder Sijtsma
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Animal Husbandry, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Clive E. West
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands
Yannoula Karabinis
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Oscar K. W. Sijtsma
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Akke J. Van Der Zijpp
Affiliation:
Department of Animal Husbandry, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Guus Koch
Affiliation:
Department of Virology, Central Veterinary Institute, PO Box 365, 8200 AJ Lelystad, The Netherlands
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The effect of vitamin A deficiency or the lentogenic La Sota strain of Newcastle disease virus (NDV) infection, or both, on immunoglobulin (IgA and IgM) levels in bile and plasma were investigated. In addition, tissue distribution of IgA-, IgG- and IgM-containing cells was studied to establish the source of these Ig. Chickens (1-d-old) with limited vitamin A reserves were fed ad lib. on diets containing either marginal or adequate levels of vitamin A. At 4 weeks of age, half the chickens in each group were infected with NDV. The number of IgA- and IgM-containing cells was not significantly affected by vitamin A deficiency, demonstrating that neither class-switching nor homing of Ig-containing cells is influenced by vitamin A deficiency. Although bile IgM levels were not significantly different in vitamin A-deficient chickens compared with normal chickens, IgA levels were significantly lower. This decrease was even more pronounced in deficient NDV-infected chickens, despite the higher number of IgA-containing cells found in these birds. These results, together with the slightly increased levels of IgA in plasma of vitamin A-deficient chickens, suggest that the hepatobiliary transport of IgA is impaired by vitamin A deficiency and possibly also by NDV infection, although disturbed secretion by IgA-containing cells cannot be excluded

Keywords

Vitamin ANewcastle diseaseImmunoglobulinsChickens
Type
Vitamin A Status and Disease Interactions
Information
British Journal of Nutrition , Volume 68 , Issue 3 , November 1992 , pp. 753 - 763
Copyright
Copyright © The Nutrition Society 1992

References

Alexander, D. J. & Allan, W. H. (1974). Newcastle disease virus pathotypes. Avian Pathology 3, 269–278.CrossRefGoogle ScholarPubMed
Bang, B. G., Foard, M. & Bang, F. B. (1973). The effect of vitamin A deficiency and Newcastle disease on lymphoid cell systems in chickens. Proceedings of the Society for Experimental Biology and Medicine 143, 1140–1146.CrossRefGoogle ScholarPubMed
Beard, C. W. & Hanson, R. P. (1984). Newcastle disease. In Diseases of Poultry, 8th ed., pp. 453–470 [Hofstad, M. S., editor]. Ames, Iowa: Iowa State University Press.Google Scholar
Brandtzaeg, P. (1982). Tissue preparation methods for immunocytochemistry. In Techniques in Immuno-cytochemistry, vol. 1, pp. 1–75 [Bullock, G. R. and Petrusz, P., editors]. London: Academic Press.Google Scholar
Brown, W. R. & Kloppel, T. M. (1989). The liver and IgA: immunological, cell biological and clinical implications. Hepatology 9, 763–784.CrossRefGoogle ScholarPubMed
Davis, C. Y. & Sell, J. L. (1989). Immunoglobulin concentrations in serum and tissues of vitamin A-deficient broiler chicks after Newcastle disease virus vaccination. Poultry Science 68, 136–144.CrossRefGoogle ScholarPubMed
Driskell, W. J., Neese, J. W., Bryant, C. C. & Bashor, M. M. (1982). Measurement of vitamin A and vitamin E in human serum by high-performance liquid chromatography. Journal of Chromatography 231, 439–444.CrossRefGoogle ScholarPubMed
Heremans, J. F. (1974). Immunoglobulin A. In The Antigens, vol. 2, pp. 365–522 [M. Sela, editor]. New York: Academic Press.CrossRefGoogle Scholar
Jeurissen, S. H. M., Janse, E. M., Ekino, S., Nieuwenhuis, P., Koch, G. & De Boer, G. F. (1988). Monoclonal antibodies as probes for defining cellular subsets in the bone marrow, thymus, bursa of Fabricius, and spleen of the chicken. Veterinary Immunology and Immunopathology 19, 225–238.CrossRefGoogle ScholarPubMed
Koch, G. & Jongenelen, I. M. C. A. (1988). Quantification and class distribution of immunoglobulin-secreting cells in mucosal tissues of the chicken. In Histophysiology of the Immune System, pp. 633–639 [Fossum, S. and Rolstad, B., editors]. New York: Plenum Press.CrossRefGoogle Scholar
Lim, G. M., Sheldon, G. F. & Alverdy, J. (1988). Biliary secretory IgA levels in rats with protein-calorie malnutrition. Annals of Surgery 207, 635–640.CrossRefGoogle ScholarPubMed
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–275.CrossRefGoogle ScholarPubMed
Majumder, M. S. I., Abdus Sattar, A. K. M. & Mohiduzzaman, M. (1987). Effect of vitamin A deficiency on guinea pig Peyer's patches. Nutrition Research 7, 539–545.CrossRefGoogle Scholar
Mancini, G., Carbonera, A. O. & Heremans, J. F. (1965). Immunocytochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2, 235–254.CrossRefGoogle Scholar
McChesney, M. B. & Oldstone, M. B. A. (1987). Viruses perturb lymphocyte functions: selected principles characterizing virus-induced immunosuppression. Annual Review of Immunology 5, 279–304.CrossRefGoogle ScholarPubMed
McDermott, M. R., Mark, D. A., Befus, A. D., Baliga, B. S., Suskind, R. M. & Bienenstock, J. (1982). Impaired intestinal localization of mesenteric lymphoblasts associated with vitamin A deficiency and protein-calorie malnutrition. Immunology 45, 1–5.Google ScholarPubMed
Nauss, K. M., Phua, C.-C., Ambrogi, L. & Newberne, P. M. (1985). Immunological changes during the progressive stages of vitamin A deficiency in the rat. Journal of Nutrition 115, 909–918.CrossRefGoogle Scholar
Peppard, J. V., Rose, M. E. & Hesketh, P. (1983). A functional homologue of mammalian secretory component exists in chickens. European Journal of Immunology 13, 566–570.CrossRefGoogle ScholarPubMed
Puengtomwatanakul, S. & Sirisinha, S. (1986). Impaired biliary secretion of immunoglobulin A in vitamin A- deficient rats. Proceedings of the Society for Experimental Biology and Medicine 182, 437–442.CrossRefGoogle ScholarPubMed
Rose, M. E., Orlans, E., Payne, A. W. R. & Hesketh, P. (1981). The origin of IgA in chicken bile:its rapid active transport from blood. European Journal of Immunology 11, 561–564.CrossRefGoogle Scholar
Scicchitano, R., Stanisz, A., Ernst, P. & Bienenstock, J. (1988). A common mucosal immune system revisited. In Migration and Homing of Lymphoid Cells, vol. 2, pp. 1–34 [Husband, A. J., editor]. Boca Raton, FL: CRC Press.Google Scholar
Scrimshaw, N. S., Taylor, C. E. & Gordon, J. E. (1968). Interactions of Nutrition and Infection. WHO Monograph Series no. 57. Geneva: WHO.Google Scholar
Sijtsma, S. R. (1989). Vitamin A deficiency and Newcastle disease virus infection in chickens: a model for the study of measles infection in vitamin A-deficient children. PhD Thesis, Agricultural University Wageningen, The Netherlands.Google Scholar
Sijtsma, S. R., Rombout, J. H. W. M., Dohmen, M. J. W., West, C. E. & van der Zijpp, A. J. (1991 a). Effect of vitamin A deficiency on the activity of macrophages in Newcastle disease virus-infected chickens. Veterinary Immunology and Immunopathology 27, 17–27.CrossRefGoogle Scholar
Sijtsma, S. R., Rombout, J. H. W. M., Kiepurski, A. K., West, C. E. & van der Zijpp, A. J. (1991 b). Changes in lymphoid organs and blood lymphocytes induced by Vitamin A deficiency and Newcastle disease virus infection in chickens. Developmental and Comparative Immunology 15, 349–356.CrossRefGoogle ScholarPubMed
Sijtsma, S. R., Rombout, J. H. W. M., van der Zijpp, A. J. & West, C. E. (1990). Vitamin A deficiency impairs cytotoxic T lymphocyte activity in Newcastle disease virus infected chickens. Veterinary Immunology and Immunopathology 26, 191–201.CrossRefGoogle ScholarPubMed
Sijtsma, S. R., West, C. E., Rombout, J. H. W. M. & van der Zijpp, A. J. (1989). The interaction between vitamin A status and Newcastle disease virus infection in chickens. Journal of Nutrition 119, 932–939.CrossRefGoogle ScholarPubMed
Sirisinha, S., Darip, M. D., Moongkarndi, P., Ongsakul, M. & Lamb, A. J. (1980). Impaired local immune response in vitamin A-deficient rats. Clinical and Experimental Immunology 40, 127–135.Google ScholarPubMed
Smith, H. & Sweet, C. (1984). The pathogenicity of viruses. In Topley and Wilson's Principles of Bacteriology, Virology and Immunity, vol. 4, 7th ed., pp. 94–123 [Brown, F. and Wilson, G., editors]. London: Edward Arnold (Publishers) Ltd.Google Scholar
Snedecor, G. W. & Cochran, W. G. (1987). Statistical Methods, 8th ed. Ames, Iowa: Iowa State University Press.Google Scholar
SPSS (1984). Release 1 of SPSS-X Program. Chicago, IL: SPSS Inc.Google Scholar
Suskind, R. M. (1977). Malnutrition and the Immune Response, pp. 1–468. New York: Raven Press.Google Scholar
Takagi, H. & Nakano, K. (1983). The effect of vitamin A depletion on antigen-stimulated trapping of peripheral blood lymphocytes in local lymph nodes of rats. Immunology 48, 123–128.Google ScholarPubMed
van der Heijden, P. J., Stok, W. & Bianchi, A. T. J. (1987). Contribution of immunoglobulin-secreting cells in the murine small intestine to the total ‘background’ immunoglobulin production. Immunology 62, 551–555.Google Scholar
Winer, B. J. (1971). Statistical Principles in Experimental Design, 2nd ed. New York: McGraw Hill.Google Scholar
Wolf, G. (1977). Retinol-linked sugars in glycoprotein synthesis. Nutritional Reviews 35, 97–99.CrossRefGoogle ScholarPubMed