Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-22T17:00:24.532Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of varying the sodium or potassium intake, or both, on magnesium status in the rat

Published online by Cambridge University Press:  09 March 2007

Judith A. Charlton  and
D. G. Armstrong
Judith A. Charlton
Affiliation:
Department of Agricultural Biochemistry and Nutrition, Faculty of Agriculture, University ofNewcastle upon Tyne, Newcastle upon Tyne NEI 7RU
D. G. Armstrong
Affiliation:
Department of Agricultural Biochemistry and Nutrition, Faculty of Agriculture, University ofNewcastle upon Tyne, Newcastle upon Tyne NEI 7RU
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Alterations in sodium or potassium intake, or both, affect the distribution and excretion of magnesium in man and animals. Experiments were performed on rats to investigate the effect of varying Na, K or Na+K intakes on Na, K and Mg excretion and plasma and tissue concentrations. In Expt 1, increasing the Na intake in a linear fashion produced a significant (P < 0.05) quadratic response in urinary Mg excretion, with a decrease followed by an increase as Na intake rose. No effect was observed on faecal excretion of Mg. Plasma and tissues were sampled at the end of an 18 d collection period; concentrations of aldosterone in plasma and Mg, Na and K in plasma and tissue were determined. Increasing Na intake in a linear fashion produced a significant (P < 0.05) quadratic effect on Mg concentration in heart and muscle, i.e. a decrease followed by an increase as Na intake rose; Na intake did not affect liver or bone Mg concentrations. There were no significant effects of Na intake on plasma Mg, Na or aldosterone but plasma K fell significantly (P < 0.01) as Na intake increased. In Expt 2, constant amounts of four diets supplying adequate or high levels of Na and adequate or high levels of K but a constant intake of Mg were given to rats. The rats fed on the adequate-Na diet had a significantly (P < 0.05) higher urinary Mg excretion than those fed on the high-Na diet; Na intake did not affect faecal Mg excretion.

Keywords

Magnesium statusPotassium intakeSodium intakeRat
Type
Lipids
Information
British Journal of Nutrition , Volume 62 , Issue 2 , September 1989 , pp. 399 - 406
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Alexander, E. A. & Levinsky, N. G. (1968). An extrarenal mechanism of potassium adaption. Journal of Clinical Investigation 47, 740–748.CrossRefGoogle Scholar
DeMan, A. J. M., Hofman, J. A., Hendriks, Th., Rosmalen, F. M. A., Ross, H. A. & Benraad, Th. (1980). A direct radioimmunoassay for aldosterone: significance of endogenous cortisol. Netherlands Journal of Medicine 23, 79–83.Google Scholar
Dixon, W. J. (1983). BMDP Statistical Software. Berkeley, California: University of California Press.Google Scholar
Duarte, C. G. (1974). Magnesium loading in potassium-adapted rats. American Journal of Physiology 227, 482–486.CrossRefGoogle ScholarPubMed
Duarte, C. G. (1980). Magnesium metabolism in potassium-adapted rats. In Magnesium in Health and Disease, pp. 93–103 [Cantin, M. and Seelig, M. S. editors]. Laurel, Maryland: Spectrum Publishers.Google Scholar
Ebel, H. & Günther, T. (1980). Magnesium metabolism: a review. Journal of Clinical Chemistry and Clinical Biochemistry 18, 257–270.Google ScholarPubMed
Forbes, R. M. (1966). Effect of magnesium, potassium and sodium nutriture on mineral composition of selected tissue of the albino rat. Journal of Nutrition 88, 400–411.CrossRefGoogle ScholarPubMed
Hanna, S. & Maclntyre, I. (1960). The influence of aldosterone upon magnesium metabolism. Lancet ii, 348–350.CrossRefGoogle ScholarPubMed
Kirkbright, G. F. & Sargent, M. [editors] (1974). Practical techniques of atomic absorption and atomic fluorescence spectroscopy. In Atomic Absorption and Fluorescence Spectroscopy, pp. 441–505. London: Academic Press.Google Scholar
Larvor, P. (1976). 28Mg kinetics in ewes fed normal or tetany prone grass. Cornell Veterinarian 66, 413–429.Google ScholarPubMed
Lemann, J., Piering, W. F. & Lennon, E. J. (1970). Studies of the acute effects of aldosterone on the interrelationship between renal sodium, calcium and magnesium in normal man. Nephron 7, 117–130.CrossRefGoogle ScholarPubMed
Morris, J. G. & Gartner, R. J. W. (1975). The effect of potassium on the sodium requirement of growing steers with and without α-tocopherol supplementation. British Journal of Nutrition 34, 1–14.CrossRefGoogle ScholarPubMed
National Research Council (1978). Nutrient requirements of the laboratory rat. In Nutrient Requirements of Laboratory Animals, vol. 10, 3rd ed., pp. 7–37. Washington, D.C.: U.S. National Academy of Sciences.Google Scholar
Ryan, M. P. & Whang, R. (1983). Interrelationships between potassium and magnesium. In Potassium: Its Biologic Significance, pp. 97–106. [Whang, R. editor]. Boca Raton, Florida: CRC Press.Google Scholar
Samley, A. H. E., Brown, J. L., Globus, D. L., Kessler, R. H. & Thompson, D. D. (1960). Interrelations between renal transport system of magnesium and calcium. American Journal of Physiology 198, 595–602.Google Scholar
Schricker, B. (1985). Effect of dietary potassium sources on apparent absorption and retention of potassium, magnesium and sodium. Nutrition Reports International 31, 615–626.Google Scholar
Scott, D. & Dobson, A. (1965). Aldosterone and the metabolism of magnesium and other minerals in sheep. Quarterly Journal of Experimental Physiology 50, 42–56.CrossRefGoogle Scholar