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Effect of various levels of selenium in wheat and meat on blood Se status indices and on Se balance in Dutch men

Published online by Cambridge University Press:  09 March 2007

Hetty W. Van Der Torre ,
Wim Van Dokkum ,
Gertjan Schaafsma ,
Michel Wedel  and
Theo Ockhuizen
Hetty W. Van Der Torre
Affiliation:
Division of Nutrition and Food Research TNO, CIVO Institutes, PO Box 360, 3700 AJ Zeist, The Netherlands
Wim Van Dokkum
Affiliation:
Division of Nutrition and Food Research TNO, CIVO Institutes, PO Box 360, 3700 AJ Zeist, The Netherlands
Gertjan Schaafsma
Affiliation:
Division of Nutrition and Food Research TNO, CIVO Institutes, PO Box 360, 3700 AJ Zeist, The Netherlands
Michel Wedel
Affiliation:
Division of Nutrition and Food Research TNO, CIVO Institutes, PO Box 360, 3700 AJ Zeist, The Netherlands
Theo Ockhuizen
Affiliation:
Division of Nutrition and Food Research TNO, CIVO Institutes, PO Box 360, 3700 AJ Zeist, The Netherlands
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Abstract

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After a 5-week period of low selenium intake, twenty-four Dutch men received 55, 135 or 215 μg Se/d as Se-rich meat or bread for a 9-week period. Four unsupplemented subjects served as controls. Plasma Se increased more rapidly than erythrocyte Se levels; the increases were significantly dependent (P < 0.001) on Se intake level. Glutathione peroxidase (EC1.11.1.9; GSH-Px) activity in platelets increased rapidly after supplementation and plateaued after 4–9 weeks. At 10 weeks after supplementation ended, plasma Se levels and platelet GSH-Px were still higher than the baseline values whereas erythrocyte Se levels continued to increase. Except for the higher erythrocyte Se levels after supplementation with high-Se meat, there were no differences in bioavailability of Se between meat and wheat products. Daily urinary and faecal Se excretions as well as Se retention increased with an increased Se intake irrespective of the form of the supplement. Regression of Se excretion ν. intake indicated that 33 μg Se/d is necessary to compensate for urinary and faecal losses

Keywords

Selenium bioavailabilitySelenium balanceMeatWheatDutch men
Type
Trace Element Metabolism
Information
British Journal of Nutrition , Volume 65 , Issue 1 , January 1991 , pp. 69 - 80
Copyright
Copyright © The Nutrition Society 1991

References

REFERENCES

Cochran, W. G. & Cox, G. M. (1957). Experimental Designs. New York: John Wiley & Sons.Google Scholar
Cohen, H. J., Brown, M., Lyons, J., Avissar, N., Hamilton, D. & Liegey, P. (1988). Clinical physiological and biochemical consequences of human selenium deficiency. In Essential and Toxic Trace Elements in Human Health and Disease, pp. 201–210 [Prasad, A. S., editor]. New York: Alan R. Liss.Google Scholar
Food and Nutrition Board (1980). Recommended Dietary Allowances, 9th revised ed. Washington, DC: National Academy of Sciences.Google Scholar
Griffiths, N. M., Stewart, R. D. H. & Robinson, M. F. (1976). The metabolism of [75Se]selenomethionine in four women. British Journal of Nutrition 35, 373–382.CrossRefGoogle Scholar
Hegsted, D. M. (1975). Balance studies. Journal of Nutrition 106, 307–311.CrossRefGoogle Scholar
Ip, C. (1985). Selenium inhibition of chemical carcinogenesis. Federation Proceedings 44, 2573–2578.Google ScholarPubMed
Ip, C. (1988). Differential effect of dietary methionine on the biopotency of selenomethionine and selenite in cancer chemoprevention. Journal of the National Cancer Institute 80, 258–262.CrossRefGoogle ScholarPubMed
Isaksson, B. & Sjögren, B. (1967). A critical evaluation of the mineral and nitrogen balances in man. Proceedings of the Nutrition Society 26, 106–116.CrossRefGoogle Scholar
Johansson, E., Lindh, U. & Landstrom, E. (1983). The incorporation of selenium and alterations of macro- and trace element levels in individual blood cells following supplementation with sodium selenite and vitamin E. A nuclear microprobe application. Biological Trace Element Research 5, 433–447.CrossRefGoogle ScholarPubMed
Keshan Disease Research Group (1979 a). Observations on effect of sodium selenite in prevention of Keshan disease. Chinese Medical Journal 92, 471–476.Google Scholar
Keshan Disease Research Group. (1979 b). Epidemiologic studies on the ethiologic relationship of selenium and Keshan disease. Chinese Medical Journal 92, 777–782.Google Scholar
Koh, T. S. & Benson, T. H. (1983). Metals and other elements. Critical re-appraisal of fluorimetric method for determination of selenium in biological materials. Journal of the Association of Official Analytical Chemists 66, 918–926.Google Scholar
Levander, O. A. (1983). Considerations in the design of selenium bioavailability studies. Federation Proceedings 42, 1721–1725.Google ScholarPubMed
Levander, O. A., Alfthan, G., Arvilommi, H., Gref, C. G., Huttunnen, J. K., Kataja, M., Koivistoinen, P. & Pikkarainen, J. (1983). Bioavailability of selenium to Finnish men as assessed by platelet glutathione peroxidase activity and other blood parameters. American Journal of Clinical Nutrition 37, 887–897.CrossRefGoogle ScholarPubMed
Levander, O. A. & Morris, V. C. (1984). Dietary selenium levels needed to maintain balance in North American adults consuming self-selected diets. American Journal of Clinical Nutrition 39, 809–815.CrossRefGoogle ScholarPubMed
Levander, O. A., Sutherland, B., Morris, V. C. & King, J. C. (1981). Selenium metabolism in human nutrition. In Selenium in Biology and Medicine, pp. 256–268 [Spallholz, J. E., Martin, J. L. and Ganther, H. E., editors]. Westport, CT: AV] Publishing Co.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–275.CrossRefGoogle ScholarPubMed
Luo, X., Wei, H., Yang, C., Xing, J., Liu, X., Qiao, C., Feng, Y., Liu, J., Liu, Y., Wu, Q., Liu, X., Guo, J., Stoecker, B. J., Spallholz, J. E. & Yang, S. P. (1985 a). Bioavailability of selenium to residents in a low selenium area of China. American Journal of Clinical Nutrition 42, 439–448.CrossRefGoogle Scholar
Luo, X., Wei, H., Yang, C., Xing, J., Qiao, C., Feng, Y., Liu, J., Liu, Z., Wu, Q., Liu, Y., Stoecker, B. J., Spallholz, J. E. & Yang, S. P. (1985 b). Selenium intake and metabolic balance of 10 men from a low selenium area of China. American Journal of Clinical Nutrition 42, 31–37.CrossRefGoogle ScholarPubMed
Mertz, W. (1987). Use and misuse of balance studies. Journal of Nutrition 117, 1811–1813.CrossRefGoogle ScholarPubMed
Molin, L. & Wester, P. O. (1976). The estimated daily loss of trace elements from normal skin by desquamation. Scandinavian Journal of Clinical and Laboratory Investigation 36, 679–682.CrossRefGoogle ScholarPubMed
Mutanen, M. (1986). Bioavailability of selenium in mushrooms, Boletus edulis, to young women. International Journal for Vitamin and Nutrition Research 56, 297–301.Google ScholarPubMed
Nève, J., Vertongen, F. & Capel, P. (1988). Selenium supplementation in healthy Belgian adults: response in platelet glutathione peroxidase activity and other blood indices. American Journal of Clinical Nutrition 48, 139–143.CrossRefGoogle ScholarPubMed
Pleban, P. A., Munyani, A. & Beachum, J. (1982). Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes. Clinical Chemistry 28, 311–316.CrossRefGoogle Scholar
Robinson, M. F., Rea, H. M., Friend, G. M., Stewart, R. D. H., Snow, P. C. & Thomson, C. D. (1978). On supplementing the selenium intake of New Zealanders. 2. Prolonged metabolic experiments with daily supplements of selenomethionine, selenite and fish. British Journal of Nutrition 39, 589600.CrossRefGoogle ScholarPubMed
Snedecor, G. W. & Cochran, W. G. (1967). Statistical Methods. Ames, Iowa: Iowa State University Press.Google Scholar
Tangncy, C. C., McNair, H. N. & Driskell, J. A. (1981). Quantitation of individual tocopherols in plasma, platelets, lipids and livers by high-performance liquid chromatography. Journal of Chromatography 224, 389–397.CrossRefGoogle Scholar
Thomson, C. D., Ong, L. K. & Robinson, M. F. (1985). Effects of supplementation with high-selenium bread on selenium, glutathione peroxidase and related enzymes in blood components of New Zealand residents. American Journal of Clinical Nutrition 41, 1015–1022.CrossRefGoogle ScholarPubMed
Thomson, C. D., Robinson, M. F., Campbell, D. R. & Rea, H. M. (1982). Effect of prolonged supplementation with daily supplements of selenomethionine and sodium selenite on glutathione peroxidase activity in blood of New Zcaland residents. American Journal of Clinical Nutrition 36, 24–31.CrossRefGoogle ScholarPubMed
Thomson, C. D., Steven, S. M., Van Rij, A. M., Wade, C. R. & Robinson, M. F. (1988). Selenium and vitamin E supplementation: activities of glutathione peroxidase in human tissues. American Journal of Clinical Nutrition 48, 316323.CrossRefGoogle ScholarPubMed
Thomson, C. D. & Stewart, R. D. H. (1974). The metabolism of [75Se]selenite in young women. British Journal of Nutrition 32, 47–57.CrossRefGoogle Scholar
Van Dokkum, W., De Vos, R. H., Muys, Th. & Wesstra, J. A. (1989). Minerals and trace elements in total diets in The Netherlands. British Journal of Nutrition 61, 7–15.CrossRefGoogle ScholarPubMed
Van Rij, A. M., Thomson, C. D., McKenzie, J. M. & Robinson, M. F. (1979). Selenium deficiency in total parenteral nutrition. American Journal of Clinical Nutrition 32, 2076–2085.CrossRefGoogle ScholarPubMed
Yang, G., Wang, S., Zhou, R. & Sun, S. (1983). Endemic selenium intoxication of humans in China. American Journal of Clinical Nutrition 37, 872–881.CrossRefGoogle ScholarPubMed