Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-26T03:13:59.503Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of triacylglycerol fatty acid positional distribution on postprandial plasma metabolite and hormone responses in normal adult men

Published online by Cambridge University Press:  17 March 2008

A. Zampelas ,
Christine M. Williams ,
Linda M. Morgan ,
J. Wright  and
P. T. Quinlan
A. Zampelas
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, GuildfordGU2 5XH
Christine M. Williams
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, GuildfordGU2 5XH
Linda M. Morgan
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, GuildfordGU2 5XH
J. Wright
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, GuildfordGU2 5XH
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The present study has examined the possibility that the positional distribution of fatty acids on dietary triacylglycerol (TAG) influences the postprandial response to a liquid meal in adult subjects. Postprandial TAG, non-esterified fatty acids (NEFA), ketones, glucose, insulin and gastric inhibitory polypeptide (GIP) responses were monitored in sixteen normal adult male subjects over 6 h following consumption of test meals containing dietary TAG in which palmitic acid was predominantly on the sn-1 (Control) or sn-2 positions (Betapol). Plasma total TAG, chylomicron-rich TAG and chylomicron-poor TAG concentrations were identical in response to the two test meals. The peak increase (mean (sd)) in chylomicron TAG was 0 85 (0 46) mmol/l after the Control meal and 0 85 (0 42) mmol/l after the Betapol meal. Plasma glucose, insulin, GIP, NEFA and ketone concentrations were also very similar following the two meals. It is concluded that dietary TAG containing saturated fatty acids on the sn-2 position appear in plasma at a similar level and over a similar timescale to TAG in which saturated fatty acids are predominantly located on sn-1 or sn-3 positions. The results reported in the present study demonstrate that the positional distribution of fatty acids on dietary TAG is not an important determinant of postprandial lipaemia in adult male subjects, but do not exclude the possibility that different responses may occur when these dietary TAG are given long term.

Keywords

TriacylglycerolsPostprandial lipaemialnsulinGIP
Type
Effects of triacylglyceride positional structure on lipid metabolism
Information
British Journal of Nutrition , Volume 71 , Issue 3 , March 1994 , pp. 401 - 410
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Deuel, H. J. (1955). The Lipids, vol. 2, pp. 216–221. New York: Interscience Publishers.Google Scholar
Filer, L. J., Mattson, F. H. & Famon, S. J. (1969). Triglyceride configuration and fat absorption by the human infant. Journal of Nutrition 99, 293–298.CrossRefGoogle ScholarPubMed
Freidwald, W. T., Levy, R. I. & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clinical Chemistry 18, 499–502.CrossRefGoogle Scholar
Grundy, S. M. & Mok, Y. I. (1976). Dietary influences on serum lipids and lipoproteins. Journal of Lipid Research 31, 1149–1172.CrossRefGoogle Scholar
Kransinski, S. D., Cohn, J. S., Russell, R. M. & Schaefer, E. J. (1990). Postprandial plasma vitamin A metabolism in humans: a reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants. Metabolism 39, 357–365.CrossRefGoogle Scholar
Mahley, R. W. (1982). Atherogenic hyperlipidaemias. The cellular and molecular biology of plasma lipoproteins altered by dietary fat and cholesterol. Medical Clinics of North America 66, 375–402.CrossRefGoogle ScholarPubMed
Mattson, F. H., Noh, G. A. & Webb, M. R. (1979). The absorbability by rats of various triglycerides of stearic and oleic acids and the effect of dietary calcium and magnesium. Journal of Nutrition 109, 1682–1687.CrossRefGoogle ScholarPubMed
Mattson, F. H. & Volpenheim, R. A. (1964). The digestion and absorption of triglycerides. Journal of Biological Chemistry 239, 2712–2116.CrossRefGoogle ScholarPubMed
Morgan, L. M., Morris, B. A. & Marks, V. (1978). Radioimmunoassay for gastric inhibitory polypeptide. Annals of Clinical Biochemistry 15, 172–177.CrossRefGoogle ScholarPubMed
Pearse, A., Williams, C. M. & Marks, V. (1987). The measurement and clinical significance of β-hydroxybutyrate. Annals of Clinical Biochemistry 23, 16P.Google Scholar
Redgrave, T. G., Kodali, D. R. & Small, D. M. (1988). The effect of triacyl-sn-glycerol structure on the metabolism of chylomicrons and the triacylglycerol-rich emulsions in the rat. Journal of Biological Chemistry 263, 5118–5123.CrossRefGoogle Scholar
Southgate, D. A. T., Widdowson, E. M., Smits, B. J., Cooke, W. T., Walker, C. H. M. & Mathers, N. P. (1969). Absorption and excretion of calcium and fat by young infants. Lancet i, 487–490.CrossRefGoogle Scholar
Tomarelli, R. M., Meyer, B. J., Weaber, J. R. & Bernhart, F. W. (1968). Effect of positional distribution on the absorption of the fatty acids of human milk and infant formulas. Journal of Nutrition 95, 583–590.CrossRefGoogle ScholarPubMed
Zilversmit, D. B. (1979). Atherogenesis: a postprandial phenomenon. Circulation 60, 473–485.CrossRefGoogle ScholarPubMed