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Effect of timing of food deprivation on host resistance to fungal infection in mice

Published online by Cambridge University Press:  09 March 2007

Motoko Oarada ,
Takeshi Nikawa  and
Nobuyuki Kurita
Motoko Oarada
Affiliation:
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-8673, Japan
Takeshi Nikawa
Affiliation:
Department of Nutrition, Tokushima University School of Medicine, Tokushima 770-8503, Japan
Nobuyuki Kurita*
Affiliation:
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-8673, Japan
*
*Corresponding author:Dr Nobuyuki Kurita, fax +81 43 226 2486, email [email protected]
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Abstract

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Mice were deprived of food for a period of 72h at varying times relative to the time of infection with Paracoccidioides brasiliensis. Host resistance was diminished profoundly when the period of food deprivation was from 48h before to 24h after infection (group B). When food deprivation was initiated immediately after infection (group C), host resistance was reduced less profoundly. When food deprivation was initiated at 24 and 48h post-infection, reductions in host resistance were only moderate or not observed respectively. These results suggest that the earlier in the course of infection starvation occurs, the more profoundly host resistance is impaired. When food deprivation was initiated 72h before infection, finishing at the time of infection (group A), the reduction in host resistance was considerably less profound compared with group B mice, suggesting that refeeding initiated immediately after infection is responsible for rapid restoration of the antifungal resistance in starved mice. Infection-induced responses of corticosterone and interferon-γ were changed according to the timing of food deprivation. Group A mice, similar to non-fasted controls, showed an infection-induced increase in serum corticosterone concentration, while groups B and C did not. Group C mice showed a substantially greater infection-induced increase in serum interferon-γ compared with the other fasted and non-fasted control groups.

Keywords

Acute starvationInfectionInterferon-γCorticosterone
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue 2 , August 2002 , pp. 151 - 158
Copyright
Copyright © The Nutrition Society 2002

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