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Effect of the protein content of the diet on the vitamin B12 status in rats

Published online by Cambridge University Press:  07 January 2011

V. S. Jathar ,
R. S. Satoskar ,
B. M. Mehta  and
D. V. Rege
V. S. Jathar
Affiliation:
Radioisotope Laboratory, Department of Pharmacology, Seth G.S. Medical College, Bombay-12, India
R. S. Satoskar
Affiliation:
Radioisotope Laboratory, Department of Pharmacology, Seth G.S. Medical College, Bombay-12, India
B. M. Mehta
Affiliation:
Department of Chemical Technology, Food Section, University of Bombay, Matunga, Bombay-19, India
D. V. Rege
Affiliation:
Department of Chemical Technology, Food Section, University of Bombay, Matunga, Bombay-19, India
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Abstract

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1. The effects of the protein content of the diet on the vitamin B12 concentration of serum and of various tissues were studied in rats by means of microbiological and radioisotopic techniques.

2. Protein starvation reduced tissue weights and nitrogen contents, serum protein concentrations and haemoglobin values.

3. The vitamin B12 contents of the serum and of several organs and tissues were greater in the protein-starved animals for reasons that remain unexplained.

4. The retention of radioactive cyanocobalamin per g fresh weight was significantly greater in liver, kidney, spleen and brain in the protein-depleted rats than in those given adequate protein. However, the total tissue retention was not significantly different between these groups, so that there was a greater capacity for tissue binding and for body conservation of vitamin B12 in the protein-starved animals.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 31 , Issue 2 , March 1974 , pp. 219 - 225
Copyright
Copyright © The Nutrition Society 1974

References

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