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The effect of the β-2-adrenergic agonist clenbuterol or implantation with oestradiol plus trenbolone acetate on protein metabolism in wether lambs

Published online by Cambridge University Press:  09 March 2007

O. Bohorov ,
P. J. Buttery ,
J. H. R. D. Correia  and
J. B. Soar
O. Bohorov
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham School of Agriculture, Sutton Bonington, Nr Loughborough, Leics. LE12 5RD
P. J. Buttery
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham School of Agriculture, Sutton Bonington, Nr Loughborough, Leics. LE12 5RD
J. H. R. D. Correia
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham School of Agriculture, Sutton Bonington, Nr Loughborough, Leics. LE12 5RD
J. B. Soar
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham School of Agriculture, Sutton Bonington, Nr Loughborough, Leics. LE12 5RD
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Abstract

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1. The effects of Revalor (trenbolone acetate plus oestradiol) implantation or the inclusion of clenbuterol (a β-2-adrenergic agonist) in the diet of wether lambs was studied. Using continuous intravenous infusion of [3H]tyrosine the fractional synthetic rate of mixed protein from three separate muscles was measured.

2. Clenbuterol slightly increased growth rate but had a significant (P < 0.02) effect on food conversion efficiency. The weight and protein content of the longissimus dorsi and vastus lateralis muscles were increased but no such changes were observed for the vastus intermedius. For the longissirnus dorsi at least the increase was probably achieved by a reduction in fractional degradation rate of the muscle protein.

3. Revalor significantly increased the growth rate and food conversion efficiency of the animals. This increase was not specific for muscle. Estimated degradation rates of muscle protein were lower in the treated animals.

4. The possible mode of action of these materials was discussed. The results obtained again highlight the importance of protein degradation in controlling growth.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 57 , Issue 1 , January 1987 , pp. 99 - 107
Copyright
Copyright © The Nutrition Society 1987

References

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