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Effect of sex hormones on fasting serum triglycerides in baboons given high-sucrose diets

Published online by Cambridge University Press:  06 August 2007

T. M Coltart  and
I Macdonald
T. M Coltart
Affiliation:
Department of Physiology, Guy's Hospital Medical School, London, SE 1
I Macdonald
Affiliation:
Department of Physiology, Guy's Hospital Medical School, London, SE 1
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Abstract

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1. The incorporation of [14C]sucrose in to serum triglyceride was shown to increase in both male and female baboons after a period of high sucrose intake. During the same period of high sucrose intake there was an increase in the fasting serum triglyceride concentration of the male baboons but not of the females.

2. When the male baboons were given a parenteral oestrogen preparation in addition to the sucrose diet the increase in fasting serum triglycerides was greatly reduced but there was little alteration in the extent of the incorporation of sucrose into serum triglyceride compared to that with the diet and no oestrogen.

3. A parenteral testosterone preparation given to the female baboons in addition to sucrose diet had no effect on either the extent of incorporation of sucrose into triglyceride the fasting serum concentrations of triglyceride.

4. The findings suggest that the differing patterns of fasting triglyceride response in the male and female baboons to the sucrose diet may have resulted from oestrogen enhancing the removal of triglyceride from the serum of the female animals.

Type
Research Article
Information
British Journal of Nutrition , Volume 25 , Issue 3 , May 1971 , pp. 323 - 331
Copyright
Copyright © The Nutrition Society 1971

References

Havel, R. J. (1957). J. clin. Invest. 36, 855.CrossRefGoogle Scholar
Hegsted, D. M., Mills, R. C., Elvehjem, C. A. & Hart, E. B. (1941). J. biol. Chem. 138, 459.CrossRefGoogle Scholar
Hodges, R. E. & Krehl, W. A. (1965). Am. J. clin. Nutr. 17, 334.CrossRefGoogle Scholar
Klugh, C. A. & Irwin, M. I. (1966). Fedn Proc. Fedn Am. Socs exp. Biol. 25, 672.Google Scholar
Kummer, H. & Kurt, F. (1963). The Baboon in Medical Research p. 65. Austin, Tex: University of Texas Press.Google Scholar
Lofland, H. B. Jr (1964). Analyt. Biochem. 9, 393.CrossRefGoogle Scholar
Macdonald, I. (1965). Am. J. clin. Nutr. 16, 458.CrossRefGoogle Scholar
Macdonald, I. (1966). Am. J. clin. Nutr. 18, 86.CrossRefGoogle Scholar
Macdonald, I. (1968). Am. J. clin. Nutr. 21, 1366.CrossRefGoogle Scholar
Macdonald, I. (1970). Br. J. Nutr. 24, 537.CrossRefGoogle Scholar
Macdonald, I. & Braithwaite, D. M. (1964) Clin. Sci. 27, 23.Google Scholar
Macdonald, I. & Roberts, J. B. (1967). Metabolism 16, 572.CrossRefGoogle Scholar
Miller, D. & Crane, R. K. (1961). Biochim. biophys. Acta 52, 293.CrossRefGoogle Scholar
Reed, O. M. (1963). The Baboon in Medical Research p. 167. Austin, Tex: University of Texas Press.Google Scholar
Varley, H. (1960). Practical Clinical Biochemistry p. 259. London: Heinemann.Google Scholar