Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-29T04:44:20.123Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of riboflavin deficiency on reproductive performance and on biochemical indices of riboflavin status in the rat

Published online by Cambridge University Press:  07 March 2008

Julia M. Duerden  and
C. J. Bates
Julia M. Duerden
Affiliation:
Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 1XJ
C. J. Bates
Affiliation:
Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 1XJ
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Young female rats were made riboflavin-deficient by feeding a purified diet containing casein (210 g/kg). This basal diet provided 0.40 mg riboflavin/kg diet, to which was added additional riboflavin at 0, 0.12 or 0.25 mg/kg diet. Control animals received the same diet with 15 mg added riboflavin/kg. The diets were given for 4 weeks before mating, then throughout pregnancy and for 15 d of lactation.

2. With no added riboflavin in the diet, reproduction was severely impaired and fetal resorption was usually observed. With 0.12 mg added riboflavin/kg diet, however, reproduction was usually successful, and the growth of dams and pups was only marginally depressed in comparison with pair-fed controls optimally supplied with riboflavin.

3. The activation coefficient (stimulated: basal activity) of erythrocyte glutathione reductase (NAD(P)H) (EC 1.6.4.2)was high, and the concentration of riboflavin in the liver was correspondingly low in the dams receiving diets containing 0.12 or 0.25 mg added riboflavin/kg and in their sucking pups at 15 d post partum. Riboflavin levels in the milk from both groups of dams were about eightfold lower than in controls. There was little evidence that the sucking pups could maintain their riboflavin level at the expense of that in the maternal tissues.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 53 , Issue 1 , January 1985 , pp. 97 - 105
Copyright
Copyright © The Nutrition Society 1985

References

REFERENCES

Bamji, M. S. (1976). British Journal of Nutrition 35, 259–265.CrossRefGoogle Scholar
Barton-Wright, E. C. (1961). Laboratory Practice 10, 543.Google Scholar
Bates, C. J., Prentice, A. M., Paul, A. A., Sutcliffe, B. A., Watkinson, M. & Whitehead, R. G. (1981). American Journal of Clinical Nutrition 34, 928–935.CrossRefGoogle Scholar
Bates, C. J., Prentice, A. M., Paul, A. A., Sutcliffe, B. A. & Whitehead, R. G. (1982). Transactions of the Royal Society of Tropical Hygiene and Medicine 76, 253–258.CrossRefGoogle Scholar
Bessey, O. A., Lowry, O. H. & Love, R. H. (1949). Journal of Biological Chemistry 180, 755–769.CrossRefGoogle Scholar
Clarke, H. C. (1971). American Journal of Obstetrics and Gynecology 111, 43–46.CrossRefGoogle Scholar
Coward, K. W., Morgan, B. G. E. & Waller, L. (1942). Journal of Physiology 100, 423–431.CrossRefGoogle Scholar
Duerden, J. M. & Bates, C. J. (1983). Proceedings of the Nutrition Society 42, 84A.Google Scholar
Duerden, J. M. & Bates, C. J. (1985). British Journal of Nutrition 53, 107–115.CrossRefGoogle Scholar
Esch, M. W., Easter, R. A. & Bahr, J. M. (1981). Biology of Reproduction 25, 659–665.CrossRefGoogle Scholar
Gilman, J. P. W., Perry, F. A. & Hill, D. C. (1952). Canadian Journal of Medical Sciences 30, 383–389.CrossRefGoogle Scholar
Giroud, A. & Boisselot, J. (1947). Archives Francaises de Pediatrie 4, 317–327.Google Scholar
Giroud, A., Levy, G. & Lefebres-Boisselot, J. (1950). International Journal of Vitamin and Nutrition Research 22, 308–312.Google Scholar
Giroud, A., Levy, G., Lefebres-Boisselot, J. & Ettori, J. (1951). Bulletin de la Societe de Chimie Biologique, Paris 33, 1214–1222.Google Scholar
Grainger, R. B., O'Dell, B. L. & Hogan, A. G. (1954). Journal of Nutrition 54, 33–48.CrossRefGoogle Scholar
Greenfield, H., Briggs, G. M., Watson, R. H. J. & Yudkin, J. (1969). Proceedings of the Nutrition Society 28, 43A.Google Scholar
Leclerc, J. (1979 a). International Journal of Vitamin and Nutrition Research 49, 51–58.Google Scholar
Leclerc, J. (1979 b). International Journal of Vitamin and Nutrition Research 49, 276–285.Google Scholar
Leimbach, D. G. (1949). International Journal of Vitamin and Nutrition Research 21, 222–239.Google Scholar
Noback, C. R. & Kupperman, H. S. (1944). Proceedings of the Society for Experimental Biology and Medicine 57, 183–185.CrossRefGoogle Scholar
Olpin, S. E. & Bates, C. J. (1982). British Journal of Nutrition 47, 577–588.CrossRefGoogle Scholar
Powers, H. J., Bates, C. J., Prentice, A. M., Lamb, W. H., Jepson, M. & Bowman, H. (1983). Human Nutrition: Clinical Nutrition 37C, 413–425.Google Scholar
Prentice, A. M. & Bates, C. J. (1981). British Journal of Nutrition 45, 37–52.CrossRefGoogle Scholar
Segaloff, A. & Segaloff, A. (1944). Endocrinology 34, 346–350.CrossRefGoogle Scholar
Shepherd, T. H., Lemire, R. J., Aksu, O. & Mackler, B. (1968). Teratology 1, 75–92.CrossRefGoogle Scholar
van den Berg, H., Schreurs, W. H. P. & Joosten, G. P. A. (1978). International Journal for Vitamin and Nutrition Research 48. 12–21.Google Scholar
Warkany, J. & Schraffenberger, E. (1943). Proceedings of the Society for Experimental Biology and Medicine 54, 92–94.CrossRefGoogle Scholar
Warkany, J. & Schraffenberger, E. (1944). Journal of Nutrition 27, 477–484.CrossRefGoogle Scholar