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The effect of riboflavin deficiency in rats on the absorption and distribution of iron

Published online by Cambridge University Press:  09 March 2007

Hilary J. Powers ,
A. J. A. Wright  and
Susan J. Fairweather-tait
Hilary J. Powers
Affiliation:
MRC Dunn Nutrition Unit, Milton Road, Cambridge CB4 1XJ
A. J. A. Wright
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
Susan J. Fairweather-tait
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
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Abstract

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1. Riboflavin may play a part in the transport of iron across the gastrointestinal mucosa. Fe absorption was measured in the rat by monitoring whole-body retention of a dose of 59Fe using a small-animal γ-counter.

2. Female Norwegian Hooded rats were fed on a diet deficient in riboflavin (B2−) from 5 weeks of age. Control animals, fed on a complete diet (B2+), were weight-matched to rats fed on the B2− diet. After 7 weeks all rats were fed on a test meal extrinsically labelled with 59Fe and whole-body radioactivity measured for 15 d.

3. Riboflavin deficiency was associated with a reduction in the percentage of the dose absorbed and an increase in the rate of loss of Fe post absorption.

4. A smaller percentage of the absorbed dose was present in the livers of the riboflavin-deficient animals.

Type
Research Article
Information
British Journal of Nutrition , Volume 59 , Issue 3 , May 1988 , pp. 381 - 387
Copyright
Copyright © The Nutrition Society 1988

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