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Effect of pectin, wheat bran and cellulose on serum lipids and lipoproteins in rats fed on a low- or high-fat diet

Published online by Cambridge University Press:  09 March 2007

Jean Louis Vigne ,
Denis Lairon ,
Patrick Borel ,
Henri Portugal ,
Anne-Marie Pauli ,
Jacques Christian Hauton  and
Huguette Lafont
Jean Louis Vigne
Affiliation:
Unité 130-INSERM (Institut National de la Santé et de la Recherche Médicale), 10 avenue Viton, 13009 Marseille, France
Denis Lairon
Affiliation:
Unité 130-INSERM (Institut National de la Santé et de la Recherche Médicale), 10 avenue Viton, 13009 Marseille, France
Patrick Borel
Affiliation:
Unité 130-INSERM (Institut National de la Santé et de la Recherche Médicale), 10 avenue Viton, 13009 Marseille, France
Henri Portugal
Affiliation:
Laboratoire Central, Hôpital Ste-Marguerite, 13009 Marseille, France
Anne-Marie Pauli
Affiliation:
Laboratoire Central, Hôpital Ste-Marguerite, 13009 Marseille, France
Jacques Christian Hauton
Affiliation:
Unité 130-INSERM (Institut National de la Santé et de la Recherche Médicale), 10 avenue Viton, 13009 Marseille, France
Huguette Lafont
Affiliation:
Unité 130-INSERM (Institut National de la Santé et de la Recherche Médicale), 10 avenue Viton, 13009 Marseille, France
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Abstract

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1. Four groups of adult male Sprague–Dawley rats were fed for 6 weeks on a diet with a low-fat content (50 g/kg) and another four groups were given a diet rich in fat (250 g/kg) and cholesterol (12 g/kg). In both cases, the basal diets were either fibre-depleted or supplemented with cellulose (60 g/kg), wheat bran (100 g/kg) or low-methoxyl pectin (100 g/kg).

2. Low-methoxyl pectin displayed the most hypocholesterolaemic effect and decreased the cholesterol content of the very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), when the low-fat diet was given. When rats were fed on the high-fat diet, pectin no longer had a hypocholesterolaemic effect but still decreased the VLDL-cholesterol content. Pectin lowered serum triglyceride and VLDL-trigylceride levels only when the low-fat diet was given.

3. Wheat bran exerted no hypocholesterolaemic effect in rats fed on the low- and high-fat diets, but decreased the cholesterol content of VLDL and lowered serum triglycerides and VLDL-tryglycerides when the high-fat diet was given.

4. Purified cellulose had no significant effect on plasma lipids.

5. As shown by multivariance analysis, low-methoxyl pectin and wheat bran both beneficially modified the serum triglyceride and cholesterol variables except VLDL-triglycerides. However, the magnitude of the effect of each individual type of fibre was dependent on the fat and cholesterol content of the diet, suggesting the existence of different mechanisms of action.

Type
Clinical and Human Nutrition papers: Other Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 58 , Issue 3 , November 1987 , pp. 405 - 413
Copyright
Copyright © The Nutrition Society 1987

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