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The effect of oral contraceptive therapy and of pregnancy on serum folate levels of rural Sri Lankan women

Published online by Cambridge University Press:  24 July 2007

Navam S. Hettiarachchy ,
Sachi S. Sri Kantha  and
S. M. X. Corea
Navam S. Hettiarachchy
Affiliation:
Department of Biochemistry and Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka
Sachi S. Sri Kantha
Affiliation:
Department of Biochemistry and Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka
S. M. X. Corea
Affiliation:
Department of Biochemistry and Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka
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Abstract

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1. Serum folate level, packed cell volume and haemoglobin concentration of apparently healthy rural Sri Lankan women, between 20 and 45 years and earning up to Rs. 500 (Sri Lankan Rs. 35 ⋍ £1 Sterling) per month, were estimated during pregnancy and when on oral contraceptive (OC) treatment with Ovulen 50 (ethinyl oestradiol 0·05 mg,ethinodiol diacetate 1 mg).

2. Ovulen 50 administration led to a fall in serum folate levels which occurred very rapidly during the first 6 months and more slowly thereafter, stabilizing at 2·2 ng/ml in women of very low economic status and at 2·9 ng/ml in the more privileged.

3. There was a steady fall in serum folate concentrations during pregnancy, the levels at the end of pregnancy being higher than those in women under OC treatment for 9 months.

4. The need for folate supplementation during OC treatment is stressed.

Type
Research Article
Information
British Journal of Nutrition , Volume 50 , Issue 3 , November 1983 , pp. 495 - 501
Copyright
Copyright © The Nutrition Society 1983

References

Ahmed, F., Bamji, M. S. & Iyengar, L. (1975). American Journal of Clinical Nutrition 28, 606–615.CrossRefGoogle Scholar
Castren, O. M. & Rossi, R. R. (1970). Journal of Obstetrics and Gynecology of the British Commonwealth 77, 548–550.CrossRefGoogle Scholar
Colman, N. (1977). In Advances in Nutritional Research, vol. 1, pp. 77–124 [Draper, H. H., editor]. New York: Plenum Press.CrossRefGoogle Scholar
Gardner, G. W., Edgerton, V. R., Senewiratne, B., Barnard, R. J. & Ohira, Y. (1977). American Journal of Clinical Nutrition 30, 910–917.CrossRefGoogle Scholar
Jogaratnam, T. & de Mel, B. V. (1976). In Population of Sri Lanka, pp. 300–318, Country Monograph Series no. 4. Bangkok: ESCAP.Google Scholar
Lightbourne, R. Jr & Singh, S. (1982). Population Bulletin 37, 1–54.Google Scholar
McLean, F. W., Geine, M. N., Held, B. & Streiff, R. R. (1969). American Journal of Obstetrics and Gynecology 104, 745–747.CrossRefGoogle Scholar
Paine, C. J., Grafton, W. D., Dickson, V. L. & Eichner, E. R. (1975). Journal of American Medical Association 231, 731–733.CrossRefGoogle Scholar
Piyasena, R. D., Weerasekera, D. A., Hettiarachchy, N. & Wikramanayake, T. W. (1977). In Radioimmuno Assay and Related Procedures in Medicine, vol. II, pp. 177–192. Proceedings of International Atomic Energy Agency Symposiu., Berlin, 1977. Vienna: IAEA.Google Scholar
Pritchard, J. A., Scott, D. E. & Whalley, P. J. (1971). American Journal of Obstetrics and Gynecology 109, 341–346.CrossRefGoogle Scholar
Richards, P. & Gooneratne, W. (1980). Basic Need., Poverty and Government Policies in Sri Lanka. Geneva: ILO.Google Scholar
Shojania, A. M. & Hornady, G. J. (1973). Journal of Laboratory and Clinical Medicine 82, 869–875.Google Scholar
Shojania, A. M., Hornady, G. J. & Barnes, P. H. (1968). Lancet i, 1376–1377.CrossRefGoogle Scholar
Shojania, A. M., Hornady, G. J. & Barnes, P. H. (1969). Lancet i, 886.CrossRefGoogle Scholar
Shojania, A. M., Hornady, R. T. & Barnes, P. H. (1971). American Journal of Obstetrics and Gynecology 111, 782–791.CrossRefGoogle Scholar
Snedecor, G. W. & Cochran, W. G. (1980) Statistical Methods, 7th ed. Ame., Iowa; Iowa State University Press.Google Scholar
Streiff, R. R. (1970). Journal of American Medical Association 214, 105–108.CrossRefGoogle Scholar