Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-29T01:44:03.706Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of moderate magnesium deficiency on serum lipids, blood pressure and cardiovascular reactivity in normotensive rats

Published online by Cambridge University Press:  09 March 2007

Catherine Luthringer ,
Yves Rayssiguier ,
Elyett Gueux  and
Alain Berthelot
Catherine Luthringer
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
Yves Rayssiguier
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
Elyett Gueux
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
Alain Berthelot
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Weanling Wistar rats were pair fed for 10 weeks on a purified diet containing either normal or suboptimal quantities of magnesium (960 or 80 mg/kg respectively).

2. At week 2, hypomagnesaemia was accompanied by hypertriglyceridaemia, an increase in plasma cholesterol and a decrease in high-density-lipoprotein-cholesterol in animals fed on the Mg-deficient diet. At week 10, the increase in triglycerides observed in Mg-deficient animals was less marked while the increase in total cholesterol was more important.

3. During the whole experimental period, Mg-deficient animals never showed hypertension. At week 2, mean arterial blood pressure was significantly lower in Mg-deficient rats than in their respective controls, while heart rate was significantly increased. However, hypotension accompanied by tachycardia was a transitory phenomenon which appeared only in the early phase of deficiency.

4. Vascular reactivity was studied in vagotomized anaesthetized rats after ganglionic blockade with pentolinium and atropine sulphate. The reactivity to noradrenaline was significantly higher in Mg-deficient rats compared with pair-fed controls after 2 weeks on the experimental diet.

Type
Other Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 59 , Issue 2 , March 1988 , pp. 243 - 250
Copyright
Copyright © The Nutrition Society 1988

References

REFERENCES

Allain, C. C., Poon, L. S., Chan, C. S. G., Richemon, W. & Fu, P. C. (1974). Clinical Chemistry 20, 470–475.CrossRefGoogle Scholar
Altura, B. M. & Altura, B. T. (1985). Magnesium 4, 226–271.Google ScholarPubMed
Altura, B. M., Altura, B. G., Carella, A. & Turlapaty, P. D. M. V. (1981). Artery 9, 212–231.Google Scholar
Altura, B. M., Altura, B. T., Gebrewold, A., Ising, H. & Gunther, T. (1984). Science 223, 1315–1317.CrossRefGoogle Scholar
Berthelot, A. & Gairard, A. (1978). British Journal of Pharmacology 62, 119–205.CrossRefGoogle Scholar
Blaustein, M. (1977). American Journal of Physiology 132, C165–C171.CrossRefGoogle Scholar
Bois, P., Gascon, A. & Beaulnes, A. (1963). Nature 197, 501–503.CrossRefGoogle Scholar
Bohr, D. F. (1973). Circulation Research 32, 665–672.CrossRefGoogle Scholar
Bucolo, G. & David, H. (1973). Clinical Chemistry 19, 476–482.CrossRefGoogle Scholar
Campese, V. M., Saglikes, Y., Iseki, K. & Massry, S. G. (1984). Advances in Experimental Medicine and Biology 178, 271–274.CrossRefGoogle Scholar
Cantin, M. (1970). Laboratory Investigation 22, 558–568.Google Scholar
Cantin, M. & Huet, M. (1973). Canadian Journal of Physiology and Pharmacology 51, 835–844.CrossRefGoogle Scholar
Durlach, J. (editor) (1985). Le Magnesium en Pratique Clinique. Paris: J. B. Ballière.Google Scholar
Godfraind, T. & Kaba, A. (1972). Archives Internationales de Pharmacodynamie et de Thérapie 196, 35–49.Google Scholar
Grove, T. H. (1979). Clinical Chemistry 25, 560–564.CrossRefGoogle Scholar
Gueux, E., Rayssiguier, Y., Piot, M. C. & Alcindor, L. (1984). Journal of Nutrition 114, 1479–1483.CrossRefGoogle Scholar
Itokawa, Y., Tanaka, C. & Fujiwara, M. J. (1974). Journal of Applied Physiology 7, 835–839.CrossRefGoogle Scholar
Kalckar, H. M. (1947). Journal of Biological Chemistry 167, 477–486.CrossRefGoogle Scholar
Kimura, M., Harada, T. & Itokawa, Y. (1984). Magnesium Bulletin 3, 125.Google Scholar
Lowrimore, P. & Ward, J. A. (1985). Journal of the American College of Nutrition 4, 381.Google Scholar
Marier, J. R. & Neri, L. C. (1985). Magnesium 4, 53–59.Google ScholarPubMed
McCarron, D. A. (1983). Annals of Internal Medicine 98, 800–805.CrossRefGoogle Scholar
Miyao, N., Ikegaki, I., Nishio, A. & Ishiguro, S. (1984). Memoirs of the Faculty Agriculture, Kagoshima University 20, 111–125.Google Scholar
Rayssiguier, Y. & Gueux, E. (1983). Magnesium 2, 132–138.Google Scholar
Rayssiguier, Y. & Gueux, E. (1986). Journal of American College of Nutrition 5, 507–519.CrossRefGoogle Scholar
Rayssiguier, Y., Gueux, E., Cardot, P., Thomas, G., Robert, A. & Trugnan, G. (1986). Nutrition Research 6, 233–240.CrossRefGoogle Scholar
Rayssiguier, Y., Gueux, E. & Weiser, D. (1981). Journal of Nutrition 111, 1876–1883.CrossRefGoogle Scholar
Rayssiguier, Y., Thomasset, M., Garel, J. M. & Barlet, J. P. (1982). Hormone and Metabolic Research 14, 379–382.CrossRefGoogle Scholar
Resnick, L. M., Gupta, R. K. & Laragh, J. H. (1984). Proceedings of the National Academy of Sciences USA 81, 6511–6515.CrossRefGoogle Scholar
Schroeder, H. A. (1960). Journal of the American Medical Association 172, 1902–1908.CrossRefGoogle Scholar
Seelig, M. S. (editor) (1980). Magnesium Deficiency in the Pathogenesis of Disease. New York and London: Plenum Medical Book.CrossRefGoogle Scholar
Seelig, M. S. & Heggtveit, H. A. (1974). American Journal of Clinical Nutrition 27, 59–79.CrossRefGoogle Scholar