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The effect of meal size on the cardiovascular responses to food ingestion

Published online by Cambridge University Press:  10 October 2007

MicHael B. Sidery  and
Ian A. Macdonald
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Abstract

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Cardiac output (CO; indirect Fick), blood pressure (BP) and heart rate (HR; oscillometry), superior mesenteric artery blood flow (SMABF; Duplex Doppler) and calf blood flow (CBF; venous occlusion plethysmography) were recorded in the fasted state and for 120 min following the ingestion of 1, 2, and 3 MJ, high-carbohydrate meals in eight healthy females. BP was unchanged following food. HR (P < 0.0005) and CO (P < 0.005) rose significantly following all three meals. Integrated increments in CO over the postprandial period were greater after 3 MJ compared with the 1 and 2 MJ meals (P < 0.05). SMABF rose significantly following all three meals. The pattern of blood flow response was significantly different between the 1 and 3 MJ meals (interaction effect P < 0.02, ANOVA), with blood flow after the 3 MJ meal being significantly greater than flow after the 1 MJ meal at 15, 60, and 90 min. Similarly, the pattern of response was significantly different after the 2 and 3 MJ meals (interaction effect P < 0.03, ANOVA), with blood flow being significantly greater at 15 and 90 min after the 3 MJ meal. CBF fell significantly in the first 15 min after the 3 MJ meal and then recovered towards baseline values. No other significant changes in CBF were recorded. There are substantial peripheral and central cardiovascular changes after food in man and there appears to be a relationship between meal size and the extent of these changes.

Keywords

Cardiac outputBlood flowMeal sizeHigh-carbohydrate meal
Type
cardiovascular effect of meal size
Information
British Journal of Nutrition , Volume 71 , Issue 6 , June 1994 , pp. 835 - 848
Copyright
Copyright © The Nutrition Society 1994

References

Berne, C., Fagius, J. & Niklasson, F. (1989). Sympathetic response to oral carbohydrate administration: evidence from microelectrode nerve recordings. Journal of Clinical lnwsrigaiion 84, 1403–1409.Google Scholar
Colles, P., Juneau, M., Gregoir, J., Larivee, L.. Desideri, A. & Waters, D. (1993). Effect of a standardized meal on the threshold of exercise-induced myocardial ischemia in patients with stable angina. Journal of the Anrericcm College of Cardiology 21, 1052–1057.Google Scholar
Cowley, A. J., Fullwood, L. J., Stainer, K., Harrison, E., Muller, F. & Hampton, J. R. (1991). Post-prandial worsening of angina: all due to changes in cardiac output. British Heart Journal 66, 147–150.CrossRefGoogle ScholarPubMed
Cowley, A. J.. Murphy, D. T. & Stainer, K. (1986). A non-invasive method for measuring cardiac output: the effect of Christmas lunch. Lancet ii, 1422–1424.Google Scholar
Dagenais, G. R., Oriol, A. & Gregor, M. (1966). Haemodynamic effects of carbohydrate and proteins in man: rest and exercise. Journal of Applied Physiology, 21, 1157–1162.Google Scholar
de Mey, C., Enterling, D., Brenel, E. & Meineke, I. (1987). Postprandial changes in supine and erect heart rate, systemic blood pressure and plasma noradrenaline and renin activity in normal subjects. European Journal of Clinical Phorrncicology 32, 47 1476.Google Scholar
Donald, D. E. (1983). Splanchnic circulation. In Handbook of Physiology, section 2, part 1. Bethesda: American Physiological Society.Google Scholar
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W. & Lambert, G. (1988). Assessment of human sympathetic nervous system activity from measureinents of norepinephrine turnover. Hypertension 11, 3–20.Google Scholar
Fagan, T. C., Gourley, L. A., Sawyer, P. R., Lee, J. T., Corneux, C. B., Oexman, M. J. & Gaffney, T. E. (1982). Cardiovascular effects of a meal : clinical implications. Clinical Research 30, 7A.Google Scholar
Fagan, T. C., Sawyer, P. R., Gourley, L. A., Lee, J. T. & Gaffney, T. E. (1986). Postprandial alterations in haemodynamics and blood pressure in normal subjects. American Journal of Cardiology 58, 636–641.Google Scholar
Gallen, I. W. & Macdonald, I. A. (1990). Effect of two methods of hand heating on body temperature, forearm blood flow and deep venous oxygen saturation. American Journal of Physiology 259, E639–E643.Google Scholar
Gill, R. W. (1985). Measurement of blood flow by ultrasound: accuracy and sources of error. Ultrasound in Medicine and Biology, 11, 625–641.Google Scholar
Gladstone, S. A. (1935). Cardiac output and related functions under basal and postprandial conditions. Archiives of Internal Medicine 55, 533–546.Google Scholar
Greenfield, A. D. M., Whitney, R. J. & Mowbray, J. F. (1963). Methods for the investigation of peripheral blood flow. Briti.vh Medical Bulletin 19, 101–109.Google Scholar
Heseltine, D. & Potter, J. F. (1990). Commentary: postprandial hypotension in elderly people. Age and Ageing 19, 233–235.Google Scholar
Heseltine, D.. Potter, J. F., Hartley, G., Macdonald, I. A. & James, O. F. W. (1990). Blood pressure, heart rate and neuroeiidocrine responses to a high carbohydrate and a high fat ineal in healthy young subjects. Clinical Science 79, 517–522.Google Scholar
Hinderliter, A. L., Fitzpatrick, M. A., Scliork, N. & Julius, S. (1987). Research utility of non-invasive methods for measurement of cardiac output. Clinical Pharmacology and Therapeutics 41, 419–425.Google Scholar
Kelbaek, H., Munck, O., Christensen, N. J. & Godtfredsen, J. (1987). Autonomic nervous control of postprandial haemodynainic changes at rest and upright exercise. Journal of Applied Physiology 63, 1862–1865.Google Scholar
Kelbaek, H., Munck, O., Christensen, N. J. & Godtfredsen, J. (1989). Central haemodynamic changes after a meal. British Heart Journal 61, 506–509.Google Scholar
Laasko, M., Edelman, S. V., Brechtel, G. & Baron, A. D. (1990). Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. Journal of Clinical Investigation 85, 1844–1852.Google Scholar
Lipsitz, L. A. & Fullerton, K. J. (1986). Postprandial blood pressure reduction in healthy elderly. Journal Of American Gerontological Society, 34, 267–270.Google Scholar
Lipsitz, L. A., Nyquist, R., Wei, J. Y. & Rowe, J. W. (1983). Postprandial reduction in blood pressure in the elderly. New England Journal of Medicine 309, 81.Google Scholar
Macdonald, I. A. & Lake, D. M. (1985). An improved technique for extracting catecholamines from body fluids. Journal of Neuroscience Methods 13, 239–248.Google Scholar
McGuire, E. A. H., Helderman, J. H., Tobiii, J. D., Andres, R. & Bergman, R. (1976). Effects of arterial versus venous sampling on glucose kinetics in man. Journal of Applied Physiology 41, 165–173.Google Scholar
Moneta, G. L., Taylor, D. C., Helton, W. S., Mulholland, M. W. & Strandness, D. E. Jr (1988). Duplex ultrasound measurement of postprandial intestinal blood flow: effect of ineal composition. Gastrornterology 95, 1294–1301.Google Scholar
Muiesan, G., Sorbini, C. A., Solinas, E., Grassi, V., Casucci, G. & Pedz, E. (1968). Comparison of CO,-rebreathing methods and direct Fick methods for determining cardiac output. Journal of Applied Phiysiology 24, 424–429.Google Scholar
Muller, A. F., Hawkins, M., Batin, P., Evans, S. & Cowley, A. J. (1992). Food in chronic heart failure: improvement in central haemodynamics but deleterious effects on exercise tolerance. European Heart Journal 13, 1460–1467.Google Scholar
Nakamura, T., Moriyasu, F., Ban, N., Nishida, O., Tamada, T., Kawasaki, T., Sakai, M. & Uchino, H. (1989). Quantitative measurement of abdominal arterial blood flow using image-directed Doppler ultrdSonogrdphy: superior mesenteric. splenic, and common hepatic arterial blood flow in normal adults. Journal of Clinical Ultrasound 17, 261–268.Google Scholar
Norryd, C., Dencker, H., Lunderquist, A., Olin, T. & Tylen, U. (1975). Superior mesenteric blood flow during digestion in inan. Acta Chirurgica Sandinavica 141, 197–202.Google Scholar
Potter, J. F., Heseltine, D., Hartley, G., Matthews, J., Macdonald, I. A. & James, O. F. W. (1989). Effects of meal consumption on the postprandial blood pressure, catecholamine and insulin changes in elderly subjects. Clinical Science 77, 265–272.Google Scholar
Qamar, M. I. & Read, A. E. (1988). Effects of ingestion of carbohydrate, fat, protein and water on the mesenteric blood flow in man. Scandinavian Journal of Gastroenterology 23, 26–30.Google Scholar
Reybrouck, T. & Fagard, R. (1990). Assessment of cardiac output at rest and during exercise by a carbon dioxide rebreathing method. European Heart Journal 11, Suppl. 11, 21–25.Google Scholar
Roberts, L. N. & Breckenridge, A. M. (1986). The reproducibility of limb blood flow measurements in human volunteers at rest and after exercise by using mercury in silastic strain gauge plethysmography under standardized conditions. Clinical Science 70, 635–638.Google Scholar
Rowe, J. W., Young, J. B., Minkaer, K. L., Stevens, A. L., Pallotta, J. & Landsberg, L. (1981). Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man. Diabetes 30, 219–225.Google Scholar
Rowe, J. W., Young, J. B., Stevens, A., Kilgore, A., Pallotta, J. & Landsberg, L. (1979). Insulin increases plasma noradrenaline in man independent of changes in blood glucose. Clinical Research 27, 594A.Google Scholar
Rowell, L. B., Brengelmann, G. L., Blackmon, J. R., Bruce, R. A. & Murray, J. A. (1968). Disparities between aortic and peripheral pulse pressures induced by upright exercise and vasomotor changes in man. Circulation 37, 954–964.Google Scholar
Sidery, M. B., Blackshaw, P. E. & Macdonald, I. A. (1994). Superior mesenteric artery blood flow and gastric emptying in humans and the differential effects of high fat and high carbohydrate meals. Gut 35, 186–190.Google Scholar
Sidery, M. B., Cowley, A. J. & Macdonald, I. A. (1993). Cardiovascular responses to high fat and high carbohydrate meals in healthy elderly subjects. Clinical Science 84, 263–270.Google Scholar
Sidery, M. B., Macdonald, I. A., Cowley, A. J. & Fullwood, L. J. (1990). Cardiovascular responses to high-fat and high-carbohydrate meals in young subjects. American Journal of Physiology 261, H1430–H1436.Google Scholar
Torsdottir, I., Alpsten, M., Anderson, H., Schweizer, T. F., Tolli, H. & Wiirsch, P. (1989). Gastric emptying and glycemic response after ingestion of mashed bean or potato flakes in composite meals. American Journal of Clinical Nutrition 50, 1415–1419.Google Scholar
Waaler, B. A., Eriksen, M. & Janbu, T. (1990). The effect of a meal on cardiac output in man at rest and during moderate exercise. Acta Physiologica Scandinavica 140, 167–173.Google Scholar
Waaler, B. A., Eriksen, M. & Toska, K. (1991). The effect of meal size on postprandial increase in cardiac output. Acta Physiologica Scandinavica 142, 33–37.Google Scholar
Wallin, B. G., Sundloff, G., Eriksson, B.-M., Dominiak, P., Grobecker, H. & Lindblad, L. E. (1981). Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man. Acta Physiologica Scandinavica 111, 69–73.Google Scholar
Whitney, R. J. (1953). Measurement of volume changes in human limbs. Journal of Physiology (London) 121, 1–27.Google Scholar