Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-25T13:44:03.942Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of malnutrition on insulin binding to rat erythrocytes

Published online by Cambridge University Press:  09 March 2007

Hazel M. Payne-Robinson  and
Richard Brown
Hazel M. Payne-Robinson
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Kingston 7, Jamaica
Richard Brown
Affiliation:
Department of Medical Biochemistry, Welsh National School of Medicine, Cardiff
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Insulin binding to erythrocyte receptors was compared in malnourished and control rats. Percentage specific insulin binding to malnourished rat erythrocytes was significantly lower than to control erythrocytes (P < 0.001). The low insulin binding in the malnourished rat erythrocytes was accompanied by low insulin receptor affinity (P = 0.035).

Keywords

MalnutritionInsulin bindingErythrocytesRat
Type
Diurnal Effects in Metabolism
Information
British Journal of Nutrition , Volume 67 , Issue 2 , March 1992 , pp. 279 - 286
Copyright
Copyright © The Nutrition Society 1992

References

REFERENCES

Alleyne, G., Trust, P., Flores, H. & Robinson, H. (1972) Glucose tolerance and insulin sensitivity in malnourished children. British Journal of Nutrition 27, 585–592.CrossRefGoogle ScholarPubMed
Baig, H. A. & Edozien, J. C. (1965) Carbohydrate metabolism in kwashiorkor. Lancet ii, 662–665.Google Scholar
Brown, K. H., Suskind, R. M., Lubin, B., Kulapongs, P., Leitzmann, C. & Olsen, R. E. (1978) Changes in red blood cell membrane in protein calorie malnutrition. American Journal of Clinical Nutrition 31, 574–578.Google Scholar
Coward, W. A. (1971) The erythrocyte membrane in kwashiorkor. British Journal of Nutrition 25, 145–151.CrossRefGoogle ScholarPubMed
De Fronzo, R. A., Soman, V., Sherwin, R. S., Hendler, R. & Felig, P. (1978) Insulin binding to monocytes and insulin action in human obesity, starvation and refeeding. Journal of Clinical Investigation 62, 204–213.CrossRefGoogle ScholarPubMed
De Meyts, P. & Roth, J. (1975) Cooperativity in ligand binding: A new graphic analysis. Biochemistry and Biophysics Research Communications 66, 1118–1125.CrossRefGoogle Scholar
De Pirro, R., Fusco, A., Lauro, R., Testa, I., Ferreti, F. & De Martinis, C. (1980) Erythrocyte insulin receptors in non-insulin-dependent diabetes mellitus. Diabetes 29, 96–99.CrossRefGoogle ScholarPubMed
Dons, R. F., Ryan, J., Gorden, P. & Wachslicht-Rodbard, H. (1981) Erythrocyte and monocyte insulin binding in man. A comparative analysis in normal and disease states. Diabetes 30, 896–902.CrossRefGoogle Scholar
Gambhir, K., Archer, J. & Bradley, C. (1978) Characteristics of human erythrocyte insulin receptors. Diabetes 27, 701–708.Google Scholar
Garrel, D. R., Todd, K. S. & Calloway, D. H. (1984) Effects of marginally negative energy balance on insulin binding to erythrocytes of normal men. American Journal of Clinical Nutrition 39, 716–721.CrossRefGoogle ScholarPubMed
Grundleger, M. L. & Thenen, S. W. (1982) Decreased insulin binding, glucose transport, and glucose metabolism in soleus muscle of rats fed a high fat diet. Diabetes 31, 232–237.CrossRefGoogle ScholarPubMed
Hales, C. N. & Randle, P. J. (1963) Immunoassay of insulin with insulin-antibody precipitate. Biochemical Journal 88, 137–146.Google Scholar
Huggett, A. S. & Nixon, D. A. (1957) Use of glucose oxidase, peroxidase, and o-dianisidine in the determination of blood and urinary glucose. Lancet ii, 368–370.CrossRefGoogle Scholar
Ip, C., Tepperman, H. M., Holohan, P. & Tepperman, J. (1976) Insulin binding and insulin response of adipocytes from rats adapted to fat feeding. Journal of Lipid Research 17, 588–599.Google Scholar
James, W. P. T. & Coore, H. G. (1970) Persistent impairment of insulin secretion and glucose tolerance after malnutrition. American Journal of Clinical Nutrition 23, 386–389.CrossRefGoogle ScholarPubMed
Kaplay, S. S. (1975) Some modified properties of human erythrocyte acetyl cholinesterase in protein-calorie deficient subjects. Indian Journal of Biochemistry and Biophysics 12, 284–286.Google Scholar
Kaplay, S. S. (1978) Erythrocyte membrane Na+ and K+ activated adenosine triphosphate in protein-calorie malnutrition. American Journal of Clinical Nutrition 31, 579–584.Google Scholar
Kosmakos, F. C., Nagulsparan, M. & Bennett, P. (1980) Insulin binding to erythrocytes: A negative correlation with red cell age. Journal of Clinical Endocrinology and Metabolism 51, 46–50.Google Scholar
Narayanareddy, K. & Kaplay, S. S. (1982) (3H) Ouabain binding to human erythrocytes in protein-energy malnutrition. Clinica Chimica Acta 122, 271–277.CrossRefGoogle ScholarPubMed
Neufeld, N. D., Ezrin, C., Corbo, L., Long, D. & Bush, M. A. (1986) Effects of caloric restriction and exercise on insulin receptors in obesity: Association with changes in membrane lipids. Metabolism 35, 580–587.Google Scholar
Olevsky, J. M. & Reaven, G. M. (1977) Insulin binding in diabetes: Relationships with plasma insulin levels and insulin sensitivity. Diabetes 26. 680–686.CrossRefGoogle Scholar
Patrick, J. & Golden, M. H. N. (1977) Leucocyte electrolytes and sodium transport in protein energy malnutrition. American Journal of Clinical Nutrition 30, 1478–1481.CrossRefGoogle ScholarPubMed
Payne-Robinson, H. M., Coore, H. G. & Golden, M. H. N. (1988) Red cell insulin binding in Jamaican malnourished children. Clinical Research 36, 792A Abstr.Google Scholar
Ramanadham, M. & Kaplay, S. S. (1982) Erythrocyte osmotic fragility in protein-energy malnutrition: cholesterol, phospholipid and Ca2+, Mg2+ adenosine triphosphatase. Biochemical Medicine 27, 226–231.Google Scholar
Ramdath, D., Golden, M. & Bennett, F. (1985) Superoxide dismutase in red cell fractions in severe malnutrition. West Indian Medical Journal 34, Suppl., 46.Google Scholar
Robinson, H. M. & Picou, D. (1977) A comparison of fasting plasma insulin and growth hormone concentrations in marasmic, kwashiorkor, marasmic-kwashiorkor, and underweight children. Pediatatric Research 11, 637–640.Google Scholar
Scatchard, G. (1949) The attraction of proteins for small molecules and ions. Annals of the New York Academy of Sciences 51, 660–672.Google Scholar
Spanheimer, R. C., Bar, R. S., Ginsberg, B. H., Peacock, M. L. & Martino, I. (1982) Comparison of insulin binding to cells of fed and fasted obese patients: Results in erythrocytes and monocytes. Journal of Clinical Endocrinology and Metabolism 54, 40–46.Google Scholar
Sun, J. V., Tepperman, H. M. & Tepperman, J. (1977) A comparison of insulin binding by liver plasma membranes of rats fed a high glucose or a high fat diet. Journal of Lipid Research 18, 533–539.Google Scholar
Thakur, V. S., Thakur, V., Singh, O., Mittal, A., Karmakar, M. G. & Ahuja, M. M. S. (1988) Protein calorie malnutrition: is the basic anomaly in insulin secretion or tissue receptors? Diabetologia 31, 403.Google Scholar
Vajreswari, A., Narayanareddy, K. & Srinivasa Rao, P. (1990) Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. Metabolism 39, 779–782.Google Scholar
Wachslicht-Rodbard, H., Gross, H. A., Rodbard, D., Ebert, M. H. & Roth, J. (1979) Increased insulin binding to erythrocytes in Anorexia nervosa. Restoration to normal with refeeding. New England Journal of Medicine 300, 882–887.CrossRefGoogle ScholarPubMed
Ward, G. M. & Harrison, L. C. (1986) Structure of the human erythrocyte insulin receptor. Diabetes 35, 101–105.Google Scholar
Ward, G. M., Naylor, B. A., Sargent, R. M. & Turner, R. C. (1984) Abnormal dietary regulation of erythrocyte insulin receptor affinity in non-insulin dependent diabetes mellitus. Clinical Endocrinology 20, 671–682.Google Scholar
Weinkove, C., Weinkove, E. & Pimstone, B. (1976) Glucose tolerance and insulin release in malnourished rats. Clinical Science and Molecular Medicine 50, 153–163.Google Scholar
Wolff, J. A., Margolis, S., Bujdoso-Wolff, K., Matusick, E. & MacLean, W. C. Jr (1984) Plasma and red blood cell fatty acid composition in children with protein-calorie malnutrition. Pediatric Research 18, 162–167.Google Scholar