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The effect of low and moderate fat intakes on the postprandial lipaemic and hormonal responses in healthy volunteers

Published online by Cambridge University Press:  09 March 2007

Farideh Shishehbor ,
Helen M. Roche  and
Michael J. Gibney
Farideh Shishehbor
Affiliation:
Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland
Helen M. Roche
Affiliation:
Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland
Michael J. Gibney*
Affiliation:
Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland
*
*Corresponding author: fax +353 1 454 2043, email [email protected]
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Abstract

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Present literature indicates that whereas an acute fat intake of 5 g does not elicit a postprandial triacylglycerolaemic response, 20 g of fat does. Since 67 % of fat intake occasions involve fat doses of less than 20 g, the present study examined the effect of a relatively low-fat (LF) meal (0·2 g/kg body weight; mean 14 g) on postprandial triacylglycerol (TAG) metabolism, compared with a high-fat (HF) meal (0·6 g/kg body weight; mean 43 g), a fat dose which is more typical of laboratory studies. Plasma- and chylomicron-TAG concentrations increased significantly (P ≤ 0·001) following both meals, and the increase was significantly (P ≤ 0·02) greater after the HF meal. The postprandial areas under the curves and maximal postprandial TAG concentrations for plasma- and chylomicron-TAG were significantly higher following the HF meal (P ≤ 0·05). Postprandial plasma insulin and gastric inhibitory polypeptide concentrations increased significantly (P ≤ 0·001) after each meal, but there was no difference between the two meals. These data show that modest amounts of fat in a meal will elicit a measurable postprandial TAG response. Since postprandial lipaemia affects the composition and concentration of the TAG- and cholesterol-rich lipoproteins, controlling dietary TAG supply may influence the metabolic fate of these lipoproteins.

Keywords

Postprandial lipaemiaTriacylglycerolsDietary fat
Type
Short communication
Information
British Journal of Nutrition , Volume 81 , Issue 1 , January 1999 , pp. 25 - 30
Copyright
Copyright © The Nutrition Society 1999

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