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The effect of iron substrate on mitochondria1 haem synthesis in copper deficiency

Published online by Cambridge University Press:  07 March 2008

Darryl M. Williams ,
F. Scott Kennedy  and
Brenda G. Green
Darryl M. Williams
Affiliation:
Departments of Internal Medicine and Biochemistry, Louisiana State University Medical Center in Shreveport, PO Box 33932, Shreveport, Louisiana 71130-3932, USA
F. Scott Kennedy
Affiliation:
Departments of Internal Medicine and Biochemistry, Louisiana State University Medical Center in Shreveport, PO Box 33932, Shreveport, Louisiana 71130-3932, USA
Brenda G. Green
Affiliation:
Departments of Internal Medicine and Biochemistry, Louisiana State University Medical Center in Shreveport, PO Box 33932, Shreveport, Louisiana 71130-3932, USA
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Abstract

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1. Studies of iron utilization and haem synthesis were carried out with hepatic mitochondria obtained from copper-deficient and pair-fed control rats.

2. Ferric chloride can be used as Fe substrate for mitochondrial haem synthesis in the presence of succinate. Utilization is further enhanced by the addition of FMN.

3. Ferritin does not support haem synthesis in the presence of succinate alone, but does support haem synthesis when FMN is added.

4. Mitochondria1 haem synthesis is impaired in Cu deficiency when either FeCl3 or homologous ferritin is used as Fe substrate.

5. The results of the present study suggest that impaired haem synthesis in Cu deficiency occurs at a step following the chemical reduction of Fe substrate.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 53 , Issue 1 , January 1985 , pp. 131 - 136
Copyright
Copyright © The Nutrition Society 1985

References

REFERENCES

Baker, E., Morton, A. G. & Tavill, A. S. (1980). British Journal of Haematology 45, 607–620.CrossRefGoogle Scholar
Barnes, R. & Jones, O. T. G. (1973). Biochimica et Biophysica Acta 304, 304–308.CrossRefGoogle Scholar
Drysdale, J. W. & Munro, H. N. (1965). Biochemical Journal 95, 851–858.CrossRefGoogle Scholar
Evans, J. L. & Abraham, P. A. (1973). Journal of Nutrition 103, 196–201.CrossRefGoogle Scholar
Goodman, J. R. & Dallman, P. R. (1969). Blood 34, 747–753.CrossRefGoogle Scholar
Ibrahim, N. G., Friedland, M. L. & Levere, R. D. (1983). Progress in Hematology 13, 75–130.Google Scholar
Jones, T., Spencer, R. & Walsh, C. (1978). Biochemistry 17, 4011–4017.CrossRefGoogle Scholar
Lee, G. R., Williams, D. M. & Cartwright, G. E. (1976). In Trace Elements in Human Health and Disease, vol. 1, Zinc and Copper, pp. 373–393 [Prasad, A. S. and Oberleas, D., editors]. New york: Academic press.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Journal of Biological Chemistry 193, 265–275.CrossRefGoogle Scholar
Nunez, M. T., Glass, J. & Robinson, S. H. (1978). Biochimica et Biophysica Acta 509, 170–180.CrossRefGoogle Scholar
Osaki, S. & Johnson, D. A. (1969). Journal of Biological Chemistry 244, 5757–5765.CrossRefGoogle Scholar
Porra, R. J. & Jones, O. T. G. (1963). Biochemical Journal 87, 181–185.CrossRefGoogle Scholar
Prohaska, J. R. (1983). Journal of Nutrition 113, 2048–2058.CrossRefGoogle Scholar
Ravin, H. A. (1961). Journal of Laboratory and Clinical Medicine 58, 161–168.Google Scholar
Roeser, H. P., Lee, G. R., Nacht, S. & Cartwright, G. E. (1970). Journal of Clinical Investigation 49, 2408–2417.CrossRefGoogle Scholar
Romslo, I. & Flatmark, T. (1973). Biochimica et Biophysica Acta 305, 29–40.CrossRefGoogle Scholar
Romslo, I. & Husby, P. (1980). International Journal of Biochemistry 12, 709–712.CrossRefGoogle Scholar
Seligman, P. A. (1983). Progress in Hematology 13, 131–417.Google Scholar
Sirivech, S., Driskell, J. & Frieden, E. (1977). Journal of Nutrition 107, 739–745.CrossRefGoogle Scholar
Ulvik, R. & Romslo, I. (1979). Biochimica et Biophysica Acta 588, 256–271.CrossRefGoogle Scholar
Wharton, D. C. & Tzagaloff, A. (1967). In Methods in Enzymology, vol. 10, pp. 245–250 [Estabrook, R. W. and Pullman, M. E., editors]. New york: Academic Press.Google Scholar
Williams, D. M., Kennedy, F. S. & Green, B. G. (1983). British Journal of Nutrition 50, 653–660.CrossRefGoogle Scholar
Williams, D. M., Loukopoulos, D., Lee, G. R. & Cartwright, G. E. (1976). Blood 48, 77–85.CrossRefGoogle Scholar