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The effect of iron substrate on mitochondria1 haem synthesis in copper deficiency

Published online by Cambridge University Press:  07 March 2008

Darryl M. Williams ,
F. Scott Kennedy  and
Brenda G. Green
Darryl M. Williams
Affiliation:
Departments of Internal Medicine and Biochemistry, Louisiana State University Medical Center in Shreveport, PO Box 33932, Shreveport, Louisiana 71130-3932, USA
F. Scott Kennedy
Affiliation:
Departments of Internal Medicine and Biochemistry, Louisiana State University Medical Center in Shreveport, PO Box 33932, Shreveport, Louisiana 71130-3932, USA
Brenda G. Green
Affiliation:
Departments of Internal Medicine and Biochemistry, Louisiana State University Medical Center in Shreveport, PO Box 33932, Shreveport, Louisiana 71130-3932, USA
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Abstract

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1. Studies of iron utilization and haem synthesis were carried out with hepatic mitochondria obtained from copper-deficient and pair-fed control rats.

2. Ferric chloride can be used as Fe substrate for mitochondrial haem synthesis in the presence of succinate. Utilization is further enhanced by the addition of FMN.

3. Ferritin does not support haem synthesis in the presence of succinate alone, but does support haem synthesis when FMN is added.

4. Mitochondria1 haem synthesis is impaired in Cu deficiency when either FeCl3 or homologous ferritin is used as Fe substrate.

5. The results of the present study suggest that impaired haem synthesis in Cu deficiency occurs at a step following the chemical reduction of Fe substrate.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 53 , Issue 1 , January 1985 , pp. 131 - 136
Copyright
Copyright © The Nutrition Society 1985

References

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