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Effect of intramuscular vitamin A injection on plasma levels of vitamin A and retinol-binding protein in malnourished children

Published online by Cambridge University Press:  09 March 2007

Vinodini Reddy  and
M. Mohanram
Vinodini Reddy
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Jamai-Osmania, Hyderabad 500007, AP, India
M. Mohanram
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Jamai-Osmania, Hyderabad 500007, AP, India
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Abstract

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1. Serum levels of retinol-binding protein (RBP), total vitamin A and retinyl ester were measured in twenty-four malnourished children with corneal lesions and nine normal children.

2. Initially, the RBP and vitamin A levels were significantly lower in malnourished children than in normal children.

3. After intramuscular injection of 30000 μg of aqueous vitamin A, serum levels of total vitamin A were increased significantly at 24 h and tended to fall within 5 d of treatment in both groups.

4. Before treatment, retinyl ester accounted for less than 10% of the vitamin in circulation. After vitamin A injection, it increased to 30%, a level much lower than that reported in patients with hypervitaminosis A.

5. There was no significant difference between the two groups of children and none of them showed clinical signs of toxicity. These observations indicate that administration of massive doses of vitamin A over a short period will not produce toxic effects even in malnourished children.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 45 , Issue 2 , March 1981 , pp. 229 - 232
Copyright
Copyright © The Nutrition Society 1981

References

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