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Effect of frequency of feeding of diets containing free or protein-bound lysine on the oxidation of [14C]lysine or [14C]phenylalanine by growing pigs

Published online by Cambridge University Press:  09 March 2007

E. S. Batterham  and
H. S. Bayley
E. S. Batterham
Affiliation:
Department of Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
H. S. Bayley
Affiliation:
Department of Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Abstract

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The effect of frequency of feeding (once daily or six equal portions at intervals of 3 h) of diets containing lysine (6.4 g/kg) supplied as either protein-bound or free lysine on the metabolism of essential amino acids was investigated in pigs over the 23–34 kg weight range. The amounts of radioactivity from 14CO2 produced by the pigs given oral doses of [14C]lysine or [14C]phenylalanine were determined. [14C]Lysine was confirmed to be unsuitable presumably because the oral dose was diluted by the dietary free lysine or was absorbed ahead of the protein-bound lysine, or both. With [14C]phenylalanine addition, there was a significantly (P < 0.01) greater production of 14CO2 by pigs fed once daily on the diet containing free lysine. However, with frequent feeding, there was no significant difference (P > 0.05) in the amount of 14CO2 produced by pigs from [14C]phenylalanine for either diet. Growth responses of the pigs were lower when the diet containing free lysine was given once daily (P < 0.01) but were similar when the diets were given frequently. It is concluded that the more rapid absorption of free lysine by growing pigs fed once daily results in an imbalance of amino acids at the sites of metabolism. This leads to greater oxidation of essential amino acids than occurs when all the amino acids are supplied in the protein-bound form. With frequent feeding, a better balanced supply of amino acids is absorbed, leading to similar rates of oxidation of excess essential amino acids from diets containing either free or protein-bound lysine.

Keywords

Feeding frequencyLysineAmino acid oxidationPig
Type
Protein and Peptide Metabolism
Information
British Journal of Nutrition , Volume 62 , Issue 3 , November 1989 , pp. 647 - 655
Copyright
Copyright © The Nutrition Society 1989

References

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