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The effect of folate deficiency and different doses of folic acid supplementation on liver diseases

Published online by Cambridge University Press:  13 November 2024

Huan Ma ,
Hui Liu ,
Yu-ting Yang ,
Mei Han  and
Chun-meng Jiang Open the ORCID record for Chun-meng Jiang [Opens in a new window]
Huan Ma
Affiliation:
Department of Gastroenterology, Second Hospital of Dalian Medical University, Dalian 116000, Liaoning, People’s Republic of China Department of Hepatology, Second Hospital of Jiaxing, Jiaxing 314000, Zhejiang, People’s Republic of China
Hui Liu
Affiliation:
Department of Gastroenterology, Air Force Medical Center, Beijing 100000, People’s Republic of China
Yu-ting Yang
Affiliation:
Department of Gastroenterology, Second Hospital of Dalian Medical University, Dalian 116000, Liaoning, People’s Republic of China
Mei Han*
Affiliation:
Department of Gastroenterology, Second Hospital of Dalian Medical University, Dalian 116000, Liaoning, People’s Republic of China
Chun-meng Jiang*
Affiliation:
Department of Gastroenterology, Second Hospital of Dalian Medical University, Dalian 116000, Liaoning, People’s Republic of China
*
Corresponding authors: Mei Han; Email: [email protected]; Chun-meng Jiang; Email: [email protected]
Corresponding authors: Mei Han; Email: [email protected]; Chun-meng Jiang; Email: [email protected]
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Abstract

The liver has multiple functions such as detoxification, metabolism, synthesis and storage. Folate is a water-soluble vitamin B9, which participates in one-carbon transfer reactions, maintains methylation capacity and improves oxidative stress. Folic acid is a synthetic form commonly used as a dietary supplement. The liver is the main organ for storing and metabolising folate/folic acid, and the role of folate/folic acid in liver diseases has been widely studied. Deficiency of folate results in methylation capacity dysfunction and can induce liver disorders. However, adverse effects of excessive use of folic acid on the liver have also been reported. This review aims to explore the mechanism of folate/folic acid in different liver diseases, promote further research on folate/folic acid and contribute to its rational clinical application.

Keywords

FolateFolic acidNAFLDAlcoholic liver diseaseHepatocellular carcinoma
Type
Review
Information
British Journal of Nutrition , Volume 133 , Issue 1 , 14 January 2025 , pp. 37 - 47
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors shared co-first authorship.

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