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Effect of experimental zinc deficiency and repletion on some immunological variables in guinea-pigs

Published online by Cambridge University Press:  09 March 2007

P. C. Verma ,
R. P. Gupta ,
J. R. Sadana  and
R. K. Paul Gupta
P. C. Verma
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
R. P. Gupta
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
J. R. Sadana
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
R. K. Paul Gupta
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
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Abstract

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1. Cellular and humoral immune responses were studied in guinea-pigs fed on zinc-deficient (ZnD), Zn-adequate (control) and Zn-replete diets containing 1·25, 50 and 100 mg Zn/kg diet respectively.

2. It was found that the ZnD guinea-pigs had significantly decreased ability to elicit delayed-type hypersensitivity (DTH) response against sheep erythrocytes as compared with controls on the 9th day of immunization. This was further substantiated by histological examination of DTH-positive skin sections.

3. A significant reduction in direct splenic plaque-forming-cell response and haemagglutinating-antibody titre was also observed in ZnD guinea-pigs.

4. Serum electrophoretic studies revealed a highly disordered protein profile with a significantly depressed value for γ-globulin.

5. Zn repletion of the previously ZnD group resulted in marked, though incomplete, restoration of immunological responses.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 59 , Issue 1 , January 1988 , pp. 149 - 154
Copyright
Copyright © The Nutrition Society 1988

References

Askenase, P. (1980). In Immunology 80, pp. 830–845 [Fougereau, M. and Dausset, J., editors]. New York: Academic Press.Google Scholar
Beach, R. S., Gershwin, M. E., Makishima, R. K. & Hurley, L. S. (1980). Journal of Nutrition 110, 805–815.CrossRefGoogle Scholar
Borum, K. (1972). Acta Pathologica et Microbiologica Scandinavica 80, 287–288.Google Scholar
Carlomagno, M. A., Mintzer, C. L., Tetzlaff, C. L. & Mchurray, D. N. (1985). Nutrition Research 5, 959–968.CrossRefGoogle Scholar
Chandra, R. K. & Au, B. (1980). American Journal of Clinical Nutrition 33, 736–738.CrossRefGoogle Scholar
DePasquale-Jardieu, P. & Fraker, P. J. (1981). Federation Proceedings 40, 1130.Google Scholar
Fernandes, H., Nair, M., Onoe, K., Tanaka, T., Floyd, R. & Good, R. (1979). Proceedings of the National Academy of Sciences, USA 76, 457–461.CrossRefGoogle Scholar
Fraker, P. J., Haus, S. & Luecke, R. W. (1977). Journal of Nutrition 107, 1889–1895.CrossRefGoogle Scholar
Fraker, P. J., Jardieu, P. M., Zwickl, C. M. & Luecke, R. W. (1978). Proceedings of the National Academy of Sciences, USA 75, 5660–5664.CrossRefGoogle Scholar
Fraker, P. J., Zwickl, C. M. & Luecke, R. W. (1982). Journal of Nutrition 112, 309–313CrossRefGoogle Scholar
Gershwin, M. E., Beach, R. S. & Hurley, L. S. (1985). Nutrition and Immunity. New York: Academic Press.Google Scholar
Gupta, R. P., Verma, P. C. & Gupta, R. K. P. (1985). British Journal of Nutrition 54, 421–428.CrossRefGoogle Scholar
Horwitz, W. (1965). Official Methods of Analysis of the Association of Official Analytical Chemists, p. 193. Washington, DC: Ben Franklin Press.Google Scholar
Huisman, T. H. I. (1963). Advances in Clinical Chemistry 6, 246–249.Google Scholar
Jerne, N. K. (1974). Transplant Reviews 18, 130–191.Google Scholar
Kirchgessner, M., Roth, H. P. & Weigand, E. (1976). In Trace Elements in Human Health and Disease vol. 1 Zinc and Copper, p. 189 [Prasad, A., editor]. New York: Academic Press.Google Scholar
McBean, L. D., Smith, J. C. Jr & Halsted, J. A. (1972). Proceedings of the Society for Experimental Biology and Medicine 140, 1207–1209.CrossRefGoogle Scholar
Mitsuoka, T., Teramatsu, M., Baba, S. M. & Yaswhira, K. (1978). Immunology 34, 363–370.Google Scholar
Parker, D. & Turk, J. L. (1974). Contact Hypersensitivity in Experimental Animals, Monograph on Allergy, vol 8. Basel: Karger.Google Scholar
Tamura, S., Kurata, T., Sugimoto, M. & Egashira, Y. (1973). Japanese Journal of Medical Science and Biology 26, 161–166.CrossRefGoogle Scholar
Wootton, I. D. P. (1974). Microanalysis in Medical Biochemistry, pp. 156–158. London: J. A. Churchill Livingstone.Google Scholar