Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-30T00:38:12.087Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of dietary protein source and saponins on serum lipids and the excretion of bile acids and neutral sterols in rabbits

Published online by Cambridge University Press:  09 March 2007

Chitra Pathirana ,
M. J. Gibney  and
T. G. Taylor
Chitra Pathirana
Affiliation:
Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton
M. J. Gibney
Affiliation:
Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton
T. G. Taylor
Affiliation:
Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Four groups of six rabbits were given purified diets in which the dietary variables were protein source (isolated soya-bean protein or cow's-milk protein) with or without saponin supplementation (10 g/kg).

2. Rabbits given soya-based diets showed significantly lower serum concentrations of triglyceride and cholesterol (P < 0·01). The latter changes were confined to the cholesterol fractions of β-lipoproteins.

3. These changes in serum cholesterol were associated with a significantly increased excretion of acid and neutral sterols in animals given soya-bean protein.

4. There was no evidence to suggest that the effect of dietary protein source on serum lipids and the excretion of total and individual sterols was influenced by saponin supplementation.

5. These results do not support the hypothesis that the hypocholesterolaemia associated with plant proteins is due to the presence of saponins.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 46 , Issue 3 , November 1981 , pp. 421 - 430
Copyright
Copyright © The Nutrition Society 1981

References

Brydon, W. G., Radesse, K., Eastwood, M. A. & Lawson, M. E. (1980). Br. J. Nutr. 43, 101.CrossRefGoogle Scholar
Calvert, G. D., Blight, L. F., Topping, D. L., Yeates, R. A. & Potter, J. D. (1979). Proc. Vth int. Symp. Atherosclerosis,Houston, Abstr. 309.Google Scholar
Carroll, K. K. (1978). Lipids 13, 360.CrossRefGoogle Scholar
Carroll, K. K., Giovanetti, P. M., Huff, M. W., Moase, O., Roberts, D. C. K. & Wolfe, B. M. (1978). Am. J. clin. Nutr. 31, 1312.CrossRefGoogle Scholar
Danielson, H., Kallner, A. & Sjorvall, J. (1963). J. biol. Chem. 238, 3846.CrossRefGoogle Scholar
Descovitch, G. C., Ceredi, C., Benassi, M. S., Liverani, A., Vettori, A., Gaddi, A., Lenzi, S., Sirtori, M., Gatti, E., Mannino, G. & Scaramuzzino, G. (1979). Proc. Vth int. Symp. Atherosclerosis,Houston, Abstr. 436.Google Scholar
Griminger, P. & Fisher, H. (1958). Proc. Soc. exp. Biol. Med. 99, 424.CrossRefGoogle Scholar
Hellstrom, K., Sjovall, J. & Wigand, G. (1962). J. Lipid Res. 3, 407.Google Scholar
Hermus, R. J. J. (1979). Proc. 3rd Eur. Nutr. Conf., Var Foda 31, Suppl. 181.Google Scholar
Karlstrom, B., Boberg, J., Gustaffson, I-B., Lithell, N., Versby, B. & Werner, I. (1979). Proc. 3rd Eur. Nutr. Conf., Var Foda 31, Suppl. 188.Google Scholar
Katan, M. B., Vroomen, L. & Hermus, R. J. J. (1980). Proc. VIIth int. Drug Symp., Drugs Affecting Lipid Metabolism,Milan, p. 104.Google Scholar
Kessler, G. & Lederer, H. (1965). In Automation in Analytical Chemistry, p. 341 [Skeggs, L. T., editor]. New York: Mediaid Inc.Google Scholar
Kim, D. N., Lee, K. T., Reiner, J. T. & Thomas, W. A. (1980). Proc. VIIth int. Drug Symp., Drugs Affecting Lipid Metabolism,Milan, p. 273.Google Scholar
Kritchevsky, D. (1979). Lancet i, 610.CrossRefGoogle Scholar
Malinow, M. R., McLaughlin, P., Stafford, C., Livingstone, A. L., Kohler, G. O. & Cheeke, P. R. (1979). Am. J. clin. Nutr. 32, 1810.CrossRefGoogle Scholar
Meeker, D. R. & Kesten, H. D. (1940). Proc. Soc. exp. Biol. Med. 45, 543.CrossRefGoogle Scholar
Morgan, B., Heald, M., Brooks, S. G., Tee, J. L. & Green, J. (1972). Poultry Sci. 51, 677.CrossRefGoogle Scholar
Newman, H. A., Kummerow, F. A. & Scott, H. H. (1957). Poultry Sci. 37, 42.CrossRefGoogle Scholar
Noseda, G., Fragiacomo, C., Descovich, G. C., Fumagelli, R., Bernini, F. & Sirtori, C. R. (1980). Proc. VIIth int. Drug Symp., Drugs Affecting Lipid Metabolism,Milan, p. 275.Google Scholar
Oakenfull, D. G. & Fenwick, D. E. (1978). Br. J. Nutr. 40, 299.CrossRefGoogle Scholar
Oakenfull, D. G., Fenwick, D. E., Hood, R. L., Topping, D. L., Illman, R. L. & Storer, G. B. (1979). Br. J. Nutr. 42, 209.CrossRefGoogle Scholar
Pathirana, C., Gibney, M. J. & Taylor, T. G. (1980). Atherosclerosis 36, 595.CrossRefGoogle Scholar
Potter, J. D., Topping, D. L. & Oakenfull, D. (1979). Lancet i, 223.CrossRefGoogle Scholar
Roberts, D. C. K., Stalmach, M. E. & Carroll, K. K. (1979). Proc. 3rd Eur. Nutr. Conf., Var Foda 31, Suppl. 247.Google Scholar
Sabine, J. R. (1977). Cholesterol. New York: Marcel Dekker.Google Scholar
Sautier, C., Doucet, C., Flament, C. & Lemonnier, D. (1979). Atherosclerosis 34, 233.CrossRefGoogle Scholar
Sirtori, C. R., Agradi, E., Conti, E., Mantero, O. & Gatti, E. (1977). Lancet ii, 275.CrossRefGoogle Scholar
Sirtori, C. R., Gatti, E., Mantero, O., Conti, F., Agradi, E., Tremoli, E., Sirtori, M., Fratterigo, L., Tarazzi, L. & Kritchevsky, D. (1979). Am. J. clin. Nutr. 32, 1645.CrossRefGoogle Scholar
Steel, R. G. D. & Torrie, J. H. (1960). Principles and Procedures in Statistics. New York: McGraw-Hill.Google Scholar
Topping, D. L., Calvert, G. D., Storer, G. B., Illman, R. J., Oakenfull, D. G. & Weller, R. A. (1980). Am. J. clin. Nutr. 33, 783.CrossRefGoogle Scholar
Van Raaij, J. M. A., Katan, M. B. & Hautvast, J. G. A. J. (1979). Lancet ii, 958.CrossRefGoogle Scholar
Warnick, G. R. & Albers, J. J. (1978). J. Lipid Res. 19, 65.CrossRefGoogle Scholar
Wells, W. W. & Makita, M. (1962). Analyt. Biochem. 4, 204.CrossRefGoogle Scholar