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Effect of dietary protein level on in vivo and in vitro vitamin A esterase activity in the chick

Published online by Cambridge University Press:  09 March 2007

I. Nir ,
I. Bruckental ,
I. Ascarelli  and
A. Bondi
I. Nir
Affiliation:
Department of Animal Nutrition and Agricultural Biochemistry, Faculty of Agriculture, Hebrew University, Rehovot, Israel
I. Bruckental
Affiliation:
Department of Animal Nutrition and Agricultural Biochemistry, Faculty of Agriculture, Hebrew University, Rehovot, Israel
I. Ascarelli
Affiliation:
Department of Animal Nutrition and Agricultural Biochemistry, Faculty of Agriculture, Hebrew University, Rehovot, Israel
A. Bondi
Affiliation:
Department of Animal Nutrition and Agricultural Biochemistry, Faculty of Agriculture, Hebrew University, Rehovot, Israel
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Abstract

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1. The efficiency of absorption of and liver storage from a single oral dose of 10000 i.u. vitamin A palmitate decreased in chicks reared on a diet containing 10% protein as compared to the efficiency in chicks reared on a diet in which the protein level was adequate. When the chicks were given orally an equivalent dose of vitamin A alcohol, the absorption was equally efficient at both dietary protein levels.

2. The vitamin A alcohol content of this intestine, plasma and liver of chicks dosed with vitamin A palmitate was decreased by protein restriction. The physiological change responsible for this decrease seems to be the lowering of the hydrolysing activity for vitamin A palmitate in pancreas and in the duodenal mucosa.

3. The importance of the enzymic step in the absorption of an oral dose of vitamin A palmitate is shown by the finding that protein malnutrition reduced only slightly the final liver stores when vitamin A in its different forms (palmitate, acetate or alcohol) was injected directly into the blood stream.

4. The uptake of injected vitamin A from the blood was much delayed when the vitamin was injected as palmitate, i.e. the ester of a long-chain fatty acid, instead of the acetate ester of the free alcohol.

5. When vitamin A was injected, the liver content did not rise continuously with time, but showed a temporary decrease after a certain period. The phenomenon was apparently due to changes in the rate of the two inverse processes of uptake of the vitamin by the liver and liberation from it.

Type
Research Article
Information
British Journal of Nutrition , Volume 21 , Issue 3 , September 1967 , pp. 565 - 581
Copyright
Copyright © The Nutrition Society 1967

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