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The effect of dietary lipid changes on the fatty acid composition and function of liver, heart and brain mitochondria in the rat at different ages

Published online by Cambridge University Press:  09 March 2007

V. Barzanti ,
M. Battino ,
A. Baracca ,
M. Cavazzoni ,
M. Cocchi ,
R. Noble ,
M. Maranesi ,
E. Turchetto  and
G. Lenaz
V. Barzanti
Affiliation:
Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
M. Battino
Affiliation:
Institute of Biochemistry, University of Ancona, Via Ranieri Monte D'Ago, 60100 Ancona, ltaly
A. Baracca
Affiliation:
Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
M. Cavazzoni
Affiliation:
Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
M. Cocchi
Affiliation:
Department of Biochemical Sciences, The Scottish Agricultural College, Auchincruive, Ayr KA6 5HW
R. Noble
Affiliation:
Department of Biochemical Sciences, The Scottish Agricultural College, Auchincruive, Ayr KA6 5HW
M. Maranesi
Affiliation:
Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
E. Turchetto
Affiliation:
Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
G. Lenaz
Affiliation:
Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
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Abstract

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A correlation between dietary lipids and cellular enzyme activities is a problem that has only been partially addressed by nutritionists. Therefore, changes in the fatty acid composition and the activities of some key metabolic enzymes (ubiquinol-2-cytochrome c reductase (EC 1.10.2.2), cytochrome oxidase (EC 1.9.3.1) and ATPase (EC 3.6.1.3)) in the mitochondria of liver, heart and brain of rats fed on diets differing extensively in their polyunsaturated fatty acid compositions have been investigated. The results showed that fatty acid compositional changes brought about by the dietary differences were associated with extensive changes in the activities of these key enzymes in the mitochondria. The extent of the influence differed considerably with the period over which the diets were fed. The role of dietary lipids to effect changes through the preservation of membrane structural integrity is discussed.

Keywords

Fat intakeMitochondria1 fatty acidsMetabolic enzymes
Type
Dietary lipids and tissue lipids
Information
British Journal of Nutrition , Volume 71 , Issue 2 , February 1994 , pp. 193 - 202
Copyright
Copyright © The Nutrition Society 1994

References

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