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The effect of dietary 1,25-dihydroxycholecalciferol in preventing tibial dyschondroplasia in broilers fed on diets imbalanced in calcium and phosphorus

Published online by Cambridge University Press:  09 March 2007

J. Sarah Rennie ,
Colin C. Whitehead  and
Barry H. Thorp
J. Sarah Rennie
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
Colin C. Whitehead
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
Barry H. Thorp
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
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Abstract

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Three experiments were carried out to investigate the effects of supplemental dietary 1·25-dihydroxycholecalciferol (1·25(OH)2cholecalciferol) and a low dietary Ca:P ratio on the occurrence of tibial dyschondroplasia (TD) in 3-week-old broilers. Histopathology was used to diagnose TD. In the first experiment, feeding a diet containing 7·5 g Ca and 7·6 g P/kg gave a higher incidence of TD than a control diet containing normal amounts of Ca and P (12 and 6 g/kg respectively). Increasing the dietary supplement of cholecalciferol in the imbalanced diet prevented rickets but did not decrease the incidence of TD. In the second experiment, supplementing the imbalanced diet with 10 μg 1·25(OH)2cholecalciferol/kg prevented TD completely but also gave a slight growth depression. In the third experiment the imbalanced diet was supplemented with 0, 2·5, 5 or 10 μg 1·25(OH)2 cholecalciferol/kg. The supplement of 2·5 μg/kg depressed and the higher supplements prevented the occurrence of TD, this time without a growth depression. Feeding the 10 μg/kg supplement for the first week only did not prevent TD. Plasma total Ca, inorganic P and alkaline phosphatase (EC 3·1·3·1) were unaffected by diet but 1·25(OH)2cholecalciferol was higher on the imbalanced than on the control diet. Supplementation of the imbalanced diet with 1·25(OH)2cholecalciferol did not increase plasma levels. It is concluded that 1·25(OH)2cholecalciferol is exerting a powerful biological effect in this model of TD, but the mechanism is unclear.

Keywords

Tibial dyschondroplasiaCholecalciferol1,25(0H)2cholecalciferolCalcium-phosphorus balanceBroilers
Type
Vitamin Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 3 , May 1993 , pp. 809 - 816
Copyright
Copyright © The Nutrition Society 1993

References

Cancela, L., Theofan, G. & Norman, A. W. (1988). The pleiotropic vitamin D hormone. In Hormones and their Actions, Part I, chpt. 15, [Cooke, B. A. and van der Molen, H. J., editors]. Amsterdam: Elsevier Science Publishers BV (Biomedical Division).Google Scholar
Edwards, H. M. Jr (1987). Effects of thiuram, disulfiram and a trace element mixture on the incidence of tibial dyschondroplasia in chickens. Journal of Nutrition 117, 964–969.CrossRefGoogle Scholar
Edwards, H. M. Jr (1989). The effect of dietary cholecalciferol, 25-hydroxycholecalciferol and 1.25-dihydroxycholecalciferol on the development of tibial dyschondroplasia in broiler chickens in the absence and presence of disulfiram. Journal of Nutrition 119, 647–652.CrossRefGoogle ScholarPubMed
Edwards, H. M. Jr (1990). Efficacy of several vitamin D compounds in the prevention of tibial dyschondroplasia in broiler chickens. Journal of Nutrition 120, 1054–1061.CrossRefGoogle ScholarPubMed
Edwards, H. M. Jr & Veltmann, J. R. Jr (1983). The role of calcium and phosphorus in the etiology of tibial dyschondroplasia in young chicks. Journal of Nutrition 113, 1568–1575.CrossRefGoogle ScholarPubMed
Farquarson, C., Whitehead, C. C., Rennie, J. S., Thorp, B. H. & Loveridge, N. (1991). Cell proliferation and enzyme activities associated with the development of avian tibial dyschondroplasia: an in situ biochemical study. Bone 13, 59–67.CrossRefGoogle Scholar
Gerstenfeld, L. C., Kelly, C.M., Von Deck, M. & Lian, J. B. (1990). Effect of 1,25-dihydroxyvitamin D, on induction of chondrocyte maturation in culture: extracellular gene expression and morphology. Endocrinology 126, 1599–1609.CrossRefGoogle Scholar
Goff, J. P., Reinhardt, T. A., Beckman, M. J. & Horst, R. L. (1990). Contrasting effects of exogenous 1.25-dihydroxyvitamin D [ 1.25-(OH)2D] versus endogenous 1.25-(OH)2D, induced by dietary calcium restriction, on vitamin D receptors. Endocrinology 126, 1031–1035.CrossRefGoogle ScholarPubMed
Halley, J. T., Nelson, T. S., Kirby, L. K. & Johnson, Z. B. (1987). Effect of altering dietary mineral balance on growth, leg abnormalities and blood base excess in broiler chicks. Poultry Science 66, 1684–1692.CrossRefGoogle ScholarPubMed
Huff, W. E. (1980). Evaluation of tibial dyschondroplasia during aflatoxicosis and feed restriction in broiler chickens. Poultry Science 59, 991–995.CrossRefGoogle ScholarPubMed
Lacey, D. L. & Huffer, W. E. (1982). Studies on the pathogenesis of avian rickets. 1. Changes in epiphyseal and metaphyseal vessels in hypocalcaemic and hypophosphataemic rickets. American Journal of Pathology 109, 288–301.Google Scholar
Leach, R. M. Jr & Nesheim, M. (1965). Nutritional, genetic and morphological studies of an abnormal cartilage formation in young chicks. Journal of Nutrition 86, 236–244.CrossRefGoogle ScholarPubMed
Leach, R. M. Jr & Nesheim, M. (1972). Further studies on tibial dyschondroplasia (cartilage abnormality) in young chicks. Journal of Numition 102, 1673–1680.Google ScholarPubMed
Lynch, M., Thorp, B. H. & Whitehead, C. C. (1991). Avian tibial dyschondroplasia as a cause of bone deformity. Avian Pathology 21, 275–285.CrossRefGoogle Scholar
Marx, S. J. (1989). Vitamin D and other calciferols. In The Metabolic Basis of Inherited Disease, 6th ed., chpt. 80, [Scriver, C. R., Beaudet, A. L., Sly, W. S. and Valle, D., editors]. New York: McGraw-Hill Information Services Company.Google Scholar
Riddell, C. & Pass, D. A. (1987). The influence of dietary calcium and phosphorus on tibial dyschondroplasia in broiler chickens. Avian Diseases 31, 771–775.CrossRefGoogle ScholarPubMed
Soares, J. H. Jr, Shellum, T. S. & Kerr, J. M. (1990). Vitamin D receptor number and affinity in tibial dyschondroplasia. Journal of Bone and Mineral Research 5, Suppl. 2, S167.Google Scholar
Suda, S., Takahashi, N., Shinki, T., Horiuchi, N., Yoshida, S., Enomoto, S. & Suda, T. (1985). ln, 25-dihydroxyvitamin D3 receptors and their action in embryonic chick chondrocytes. Calcified Tissue International 37, 82–90.CrossRefGoogle Scholar
Thorp, B. H. (1988). Relationship between the rate of longitudinal bone growth and physeal thickness in the growing fowl. Research in Veterinary Science 45, 83–85.CrossRefGoogle ScholarPubMed
Thorp, B. H., Whitehead, C. C. & Rennie, J. S. (1991). Avian tibia1 dyschondroplasia: a comparison of the incidence and severity as assessed by gross examination and histopathology. Research in Veterinary Science 51, 48–54.CrossRefGoogle Scholar
Vargas, M. I., Lamas, J. M. & Alvarenga, V. (1983). Tibial dyschondroplasia in growing chickens experimentally intoxicated with tetramethylthiuram disulphide. Poultry Science 62, 1195–1200.CrossRefGoogle Scholar
Veltmann, J. R. Jr, Rowland, G. N. & Linton, S. S. (1985). Tibial dyschondroplasia in single-comb white leghorn chicks fed tetramethylthiuram disulphide (a fungicide). Avian Diseases 29, 1269–1272.CrossRefGoogle ScholarPubMed