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Effect of dexfenfluramine on gastric emptying of a mixed solid-liquid meal in obese subjects

Published online by Cambridge University Press:  09 March 2007

Michael Horowitz ,
Anne Maddox ,
Judith Wishart ,
Jane Vernon-Roberts ,
Barry Chatterton  and
David Shearman
Michael Horowitz
Affiliation:
Departments of Medicine and Nuclear Medicine,Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
Anne Maddox
Affiliation:
Departments of Medicine and Nuclear Medicine,Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
Judith Wishart
Affiliation:
Departments of Medicine and Nuclear Medicine,Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
Jane Vernon-Roberts
Affiliation:
Departments of Medicine and Nuclear Medicine,Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
Barry Chatterton
Affiliation:
Departments of Medicine and Nuclear Medicine,Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
David Shearman
Affiliation:
Departments of Medicine and Nuclear Medicine,Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
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Abstract

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Recent studies suggest that dexfenfluramine (D-fenfluramine), because of its pure serotonergic effect, may be a more potent anti-obesity agent, associated with fewer side-effects than the racemate DL-fenfluramine. The effect of dexfenfluramine on gastric emptying of a mixed solid and liquid meal was assessed with a double-isotope scintigraphic technique in eleven obese patients. Each subject took a placebo capsule on the morning and evening of the day before, and on the morning of the first gastric emptying measurement. Dexfenfluramine was then taken at a dose of 15 mg twice daily and gastric emptying measurements were performed at 5 and at 29 d after the initiation of active treatment. Dexfenfluramine significantly slowed gastric emptying of the solid meal at both 5 and 29d when compared with the placebo (P < 0.05) and also delayed emptying of solid food from the proximal stomach (P < 0.01), but no significant effect on liquid emptying was observed. No significant side-effects were reported and there was a marginal weight loss (P< 0.005) during treatment. We conclude that inhibition of gastric emptying may contribute to the efficacy of dexfenfluramine in the treatment of obesity.

Type
Gastrointestional Motility and Function
Information
British Journal of Nutrition , Volume 63 , Issue 3 , May 1990 , pp. 447 - 455
Copyright
Copyright © The Nutrition Society 1990

References

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