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The effect of an atherogenic diet on plasma lipid composition and aortic atherosis in two strains of New Zealand White rabbit

Published online by Cambridge University Press:  09 March 2007

J. H. Moore  and
D. L. Williams
J. H. Moore
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
D. L. Williams
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
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Abstract

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1. Susceptibility to dietary induction of hypercholesterolaemia and aortic atherosis was compared in two groups of male New Zealand White rabbits. 2. Twelve rabbits were purchased from one breeding establishment (group I) and twelve from another (group 2). On arrival at the laboratory six animals from each group were killed and the aortas were removed. Blood samples were taken from the remaining twelve animals and then they were given ad lib. for a period of 40 weeks an atherogenic diet containing 20% butterfat. During this period food intake and body-weight were recorded. At the end of the period blood samples were taken from the animals and immediately afterwards they were killed and the aortas were removed. 3. No atheromatous lesions were found in the aortas of the rabbits in either group killed at the beginning of the experiment. There were no differences between the two groups of animals with respect to body-weight or concentration of cholesterol in the plasma at the beginning of the experiment, food intake during the experiment or body-weight at the end of the experiment. At the end of the experiment, the degree of aortic atherosis in the rabbits of group I was considerably greater than that in the rabbits of group 2. 4. At the end of the experiment the concentrations of total lipids, free cholesterol, esterified cholesterol and phospholipids in the plasma of the rabbits in group 1 were significantly higher than the corresponding concentrations of these lipid components in the plasma of the rabbits in group 2. The concentrations of palmitic, stearic and linoleic acids in the cholesterol esters and the concentration of palmitic acid in the unesterified fatty acids in the plasma of the rabbits in group 2 were significantly higher than the corresponding concentrations of these fatty acids in the plasma cholesterol esters and unesterified fatty acids in the rabbits of group 1. 5. It is concluded that these differences in response to the atherogenic diet were reflections of the differences in the susceptibilities to the dietary induction of hypercholesterolaemia and atherosis of the two differents strain of rabbit that had been established by the two commercial breeders. Such differences in susceptibility could readily explain certain discrepancies in the results of various research workers engaged in this field of investigation.

Type
Research Article
Information
British Journal of Nutrition , Volume 20 , Issue 3 , September 1966 , pp. 571 - 580
Copyright
Copyright © The Nutrition Society 1966

References

REFERENCES

Abell, L. L., Levy, B. B., Brodie, B. B. & Kendall, F. E. (1952). J. biol. Chem. 195, 357.CrossRefGoogle Scholar
Brown, W. D. (1959). Aust. J. exp. Biol. med. Sci. 37, 523.CrossRefGoogle Scholar
Clarkson, T. B., Prichard, R. W., Netsky, M. G. & Lofland, H. B. (1959). Archs. Path. 68, 143.Google Scholar
Funch, J. P., Kristensen, G. & Dam, H. (1962). Br. J. Nutr. 16, 497.CrossRefGoogle Scholar
Funch, J. P., Krogh, B. & Dam, H. (1960). Br. J. Nutr. 14, 355.CrossRefGoogle Scholar
Gottenbos, J. J. & Thomasson, H. J. (1961). Colloques int. Cent. natn. Rech. scient. no. 99, p. 221.Google Scholar
Haft, D. E., Roheim, P. S., White, A. & Eder, H. A. (1962). J. clin. Invest. 41, 842.CrossRefGoogle Scholar
Havel, R. J., Felts, J. M. & Van Duyne, C. M. (1962). J. Lipid Res. 3, 297.CrossRefGoogle Scholar
Lambert, G. F., Miller, J. P., Olsen, R. T. & Frost, D. V. (1958). Proc. Soc. exp. Biol. Med. 97, 544.CrossRefGoogle Scholar
Lofland, H. B. & Clarkson, T. B. (1959). Circulation Res. 7, 234.CrossRefGoogle Scholar
Lofland, H. B. & Clarkson, T. B. (1960). Proc. Soc. exp. Biol. Med. 103, 238.CrossRefGoogle Scholar
Marsh, J. B. (1963). J. biol. Chem. 238, 1752.CrossRefGoogle Scholar
Moore, J. H. (1962). J. Dairy Res. 29, 141.CrossRefGoogle Scholar
Moore, J. H. & Doran, B. M. (1962). Biochem. J. 84, 506.CrossRefGoogle Scholar
Moore, J. H. & Kon, S. K. (1963). Chemy Ind. p. 165.Google Scholar
Moore, J. H. & Williams, D. L. (1963). Can. J. Biochem. Physiol. 41, 1821.CrossRefGoogle Scholar
Moore, J. H. & Williams, D. L. (1964 a). Br. J. Nutr. 18, 253.CrossRefGoogle Scholar
Moore, J. H. & Williams, D. L. (1964 b). Br. J. Nutr. 18, 431.CrossRefGoogle Scholar
Moore, J. H. & Williams, D. L. (1964 c). Biochim. biophys. Acta 84, 41.Google Scholar
Moore, J. H. & Williams, D. L. (1965). Br. J. Nutr. 19, 407.CrossRefGoogle Scholar
Nelson, G. J. & Freeman, N. K. (1959). J. biol. Chem. 234, 1375.CrossRefGoogle Scholar
Roheim, P. S., Haft, D. E., Gidez, L. I., White, A. & Eder, H. A. (1963). J. clin. Invest. 42, 1277.CrossRefGoogle Scholar
Smith, S. C., Strout, R. G., Dunlop, W. R. & Smith, E. C. (1965). J. Atheroscler. Res. 5, 379.CrossRefGoogle Scholar
Wigand, G. (1959). Acta med. scand. 166, Suppl. no. 351.Google Scholar
Wittcoff, H. (1951). The Phosphatides, p. 171. New York: Reinhold Publishing Corp.Google Scholar