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The effect of a nutritionally-balanced cassava (Manihot esculenta Crantz) diet on endocrine function using the dog as a model 2. Thyroid

Published online by Cambridge University Press:  09 March 2007

Beryl P. Kamalu  and
Julius C. Agharanya
Beryl P. Kamalu
Affiliation:
Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria
Julius C. Agharanya
Affiliation:
Department of Chemical Pathology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria
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Abstract

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Growing dogs were divided into three groups and were fed on nutritionally-balanced diets. Control dogs were fed on a rice diet, the cassava (gari) group ate a diet in which gari provided the carbohydrate source, while the rice + cyanide group consumed the rice diet to which hydrocyanic acid (equivalent to that present in gari) was added. Each group consumed its diet for 14 weeks, during which plasma thiocyanate concentration and total serum triiodothyronine (T3) were monitored. At the end of the experiment the concentrations of the plasma free amino acids phenylalanine and tyrosine, the thyroid weights and histology were determined. While plasma thiocyanate remained undetectable in control dogs, animals consuming both gari and rice + cyanide generated significant amounts. In the control dogs and the gari group, total serum T3 increased 40 and 38.8 % respectively from the basal level by the end of the period (P < 0.02). In contrast there was a decrease in T3 by 36% in the dogs fed on rice+cyanide (P < 0.05). This group also showed significant thyroid enlargement and a histological picture consistent with parenchymatous goitre, whereas the gari group was essentially normal. The relatively low mean thyroid weight, the rise in total serum T3 level and the normal histological appearance of the gland indicate that dogs that consumed the gari diet were essentially normal with respect to their thyroid function, in spite of their high blood thiocyanate content. In contrast, dogs that consumed rice with cyanide suffered from hypothyroidism and goitre. It is suggested that the gari diet, despite generating thiocyanate endogenously, when taken in a nutritionally-balanced diet with high-quality animal protein, has no deleterious effects on thyroid function.

Keywords

ThyroidCassava dietDog
Type
Nutritional Effects on Endocrine Function
Information
British Journal of Nutrition , Volume 65 , Issue 3 , May 1991 , pp. 373 - 379
Copyright
Copyright © The Nutrition Society 1991

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