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The effect of a low-fat maternal diet on neonatal rats

Published online by Cambridge University Press:  24 July 2007

A. J. Sinclair  and
M. A. Crawford
A. J. Sinclair
Affiliation:
Nuffield Institute of Comparative Medicine, Zoological Society of London, Regent's Park, London NWI
M. A. Crawford
Affiliation:
Nuffield Institute of Comparative Medicine, Zoological Society of London, Regent's Park, London NWI
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Abstract

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1. Rats were raised on a low-fat diet containing 6 g fat/kg. Females of the second generation were bred and only 11% of their pups survived to weaning age compared with a 66% survival for control pups. Pups were killed 8–12 h after birth and their tissues were analysed.

2. Pups in the low-fat group had smaller body, brain and liver weights than control pups; the lipid contents of body, brain and liver were also significantly less.

3. In the liver triglycerides from the control group the C20 and C22 polyenoic fatty acids constituted 33% of the total fatty acids. The liver triglyceride concentration in the low-fat group was lower and the concentration of the long-chain polyenoic fatty acids in this fraction was 20% of the control value. The milk fatty acids from the low-fat group contained only 33% as much of the C18 to C22 polyenoic fatty acids compared with the control group.

4. In the brain lipids from the low-fat group, changes in the fatty acid composition were less marked than in the liver lipids. In these experiments there were only small amounts of 20:3ω9 in the tissue lipids; the ratio to 20:4ω6 was less than 1.

5. These changes are discussed in relation to the influence of dietary lipids on tissue growth especially of lipid-rich tissues such as the brain.

Type
Research Article
Information
British Journal of Nutrition , Volume 29 , Issue 1 , January 1973 , pp. 127 - 137
Copyright
Copyright © The Nutrition Society 1973

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