Some chronic diseases such as overweight/obesity, CVD and type 2 diabetes mellitus (T2DM) are closely associated with lifestyle factors and nutritional habits(1). In the last few decades, epidemiological evidence has helped to clarify the specific role of diet and its components in the prevention or elevation of the risk of these non-communicable diseases. The role that some dietary components, such as vegetable oils, may play in the determination of the risk of these conditions has been identified by observational studies and intervention trials. Since the pioneering Seven Countries Study, dietary SFA have been considered to be directly associated with higher serum cholesterol concentrations and with a higher risk of CVD. In this context, high SFA intake was considered to be the primary determinant of CVD risk in Western countries. Moreover, recommending reduction of the intake of all types of fats was considered to be a practical approach to reduce saturated fat intake, and this recommendation was included in almost all the dietary guidelines during the last two to three decades(Reference Baum, Kris-Etherton and Willett2). The high energy density and high palatability of high-fat foods were feared to exert potentially adverse effects on body weight and cardiovascular health. In addition, Ornish et al. (Reference Ornish, Brown and Scherwitz3) reported a regression of coronary atherosclerosis in a study carried out in forty-eight patients with angiographically documented CHD, in which the intervention group (twenty-eight patients) followed a low-fat diet with < 10 % of total energy as fat. This small study contributed to the building up of the myth that all types of fats, including vegetable oils, are detrimental for cardiovascular health. This belief opened the door to the recommendation of low-fat diets for the prevention of CVD. However, the results obtained in large randomised trials using low-fat diets as a paradigm of a healthy diet to prevent the development of CVD or obesity have been disappointing(Reference Howard, Van Horn and Hsia4–Reference Wing and Bolin6). A reduction in fat intake is usually compensated by a proportional increase in carbohydrate intake. In the current cultural context, most carbohydrates are highly refined and may even be more favourable for the development of obesity, T2DM and CVD than fats. The isoenergetic comparison of carbohydrate v. SFA rendered both equally detrimental for cardiovascular health(Reference Jakobsen, O'Reilly and Heitmann7), and when the comparison was made between n-6 PUFA (present in seed oils) and SFA, the intake of PUFA was found to be significantly associated with a reduced risk of CHD. In these circumstances, an alternative dietary paradigm that is different from the low-fat diet and can be more useful for developing and implementing programmes aimed at achieving prolonged weight loss and improving cardiovascular health is the traditional Mediterranean diet. This dietary pattern is rich in fat from vegetable oils (especially virgin olive oil) and includes an abundance of minimally processed plant foods (vegetables, fruits, whole grains and legumes), low consumption of meat (especially red and processed meats), moderate consumption of fish and wine (which is usually consumed with meals) and frugal meals. The high fat content of the traditional Mediterranean diet makes it more palatable and therefore more acceptable and easily sustainable in the long term. It is likely that a higher intake of vegetable oils may contribute to a greater palatability and consequently sustainability.
Vegetable oils are produced from oilseeds (i.e. sunflower), legumes (i.e. soyabean), nuts (i.e. almond) or the flesh of some fruits (i.e. olives). They are mainly composed of TAG and therefore serve as sources of fat. As all sources of fat, vegetable oils, contain different kinds of fatty acids, their compositions vary widely, but typically one type of fatty acid will predominate over the others; for example, the major fatty acid in olive oil is oleic acid, a MUFA, and the predominant fatty acid in sunflower oil is linoleic acid, a PUFA(Reference Foster, Williamson and Lunn8). Concerning vegetable oils and health, besides the predominant fatty acid in each specific oil, another issue that has to be taken into consideration is the culinary purpose, because oil has different effects on health depending on the form it is eaten (used for dressing, for cooking or for frying).
Therefore, we conducted a systematic review of the existing evidence regarding the association of vegetable oil consumption including fried food consumption with the risk of overweight/obesity or weight gain, T2DM or the metabolic syndrome (MetS), and CVD or hypertension.
Methods
A systematic search for published studies that assessed the association between vegetable oil consumption including fried food consumption and the risk of overweight/obesity or weight gain, T2DM or the MetS, and CVD and hypertension was performed in the following databases: PubMed; Web of Science; Google Scholar. Keywords such as ‘fried food’ or ‘frying’ or ‘frying oils’ or ‘vegetable oil’ or ‘dietary fats’ and ‘weight gain’ or ‘overweight’ or ‘obesity’ or ‘CHD’ or ‘CVD’ or ‘type 2 diabetes’ or ‘metabolic syndrome’ were used in the primary search. Additional published reports were obtained through other sources. The language of publication was restricted to English and Spanish. Studies that had a case–control, cohort or randomised controlled trial study design; those that considered vegetable oil consumption or fried food consumption as the exposure of interest; and those that investigated weight gain, overweight, obesity, T2DM, the MetS, CVD or hypertension as the outcome were included in the present systematic review. Reviews, editorials, comments, letters, meeting abstracts, short communications, protocols, non-human studies, studies that did not specifically consider vegetable oil or fried food consumption as exposure, and studies that did not consider weight gain, overweight, obesity, T2DM, the MetS or CVD as the outcome were excluded.
Data extraction
The following information was extracted from each included study: author and year of publication; study design; dietary intake assessment method; number of FFQ items; exposure (type of vegetable oil or fried food consumption) and categorisation; follow-up period; number of participants included and characteristics of the included participants such as age, sex and country; the outcome (weight gain, overweight, obesity, T2DM, the MetS, and CVD or hypertension); number of cases and controls in case–control studies, number of events in cohort and randomised controlled trial studies; the covariates included in the adjusted models and β-regression coefficients, OR and hazard ratios (HR) were also extracted.
Results
Literature search
The results of the literature search are shown in Fig. 1. In total, 3549 records were identified in PubMed, 388 records in the Web of Science and 832 in Google Scholar until April 2014; four additional records were identified through other sources. After exclusion of duplicate records and records that were not published in scientific journals (n 936), 3837 records were screened. In the first instance, records were screened only by title content and 3616 records were excluded. The abstracts of the remaining 221 records were read and records that did not meet the inclusion criteria were excluded, leaving a total of twenty-three articles for inclusion in the systematic review.
Fig. 1 Flow diagram depicting the identification and selection processes of relevant studies that investigated the association between vegetable oil or fried food consumption and the risk of overweight/obesity or weight gain, T2DM or the metabolic syndrome, and CVD or hypertension.
Study characteristics
The information extracted from the twenty-three studies included in the present systematic review is summarised in Tables 1–3. Studies that investigated weight gain or the risk of overweight or obesity as the outcome were conducted in the USA(Reference Mozaffarian, Hao and Rimm9, Reference Taveras, Berkey and Rifas-Shiman10) and Spain(Reference Bes-Rastrollo, Sánchez-Villegas and De la Fuente11–Reference Sayon-Orea, Bes-Rastrollo and Basterra-Gortari13); studies that assessed the incidence of T2DM or the MetS were also conducted in the USA(Reference Halton, Willett and Liu14, Reference Lutsey, Steffen and Stevens15) and Spain(Reference Salas-Salvado, Bullo and Babio16–Reference Sayon-Orea, Martinez-Gonzalez and Gea19); and studies that investigated the risk of CVD and hypertension were conducted in the USA(Reference Mozaffarian, Lemaitre and Kuller20), Spain(Reference Alonso and Martinez-Gonzalez21–Reference Estruch, Ros and Salas-Salvado25) India(Reference Rastogi, Reddy and Vaz26), Costa Rica(Reference Kabagambe, Baylin and Ascherio27), Norway(Reference Lockheart, Steffen and Rebnord28), Greece(Reference Kontogianni, Panagiotakos and Chrysohoou29), Italy(Reference Bendinelli, Masala and Saieva30) and France(Reference Samieri, Feart and Proust-Lima31) (Table 2).
Table 1 Study design characteristics of the twenty-three epidemiological studies that investigated the association between vegetable oil or fried food consumption (FFC) and weight change, incident overweight/obesity, type 2 diabetes, the metabolic syndrome, hypertension or CVD
NR, not reported; NHS, Nurses’ Health Study; T2DM, type 2 diabetes mellitus; EVOO, extra-virgin olive oil; MedDiet, Mediterranean diet; ref., reference; NA, not applicable.
Table 2 Characteristics of the twenty-three epidemiological studies that investigated the association between vegetable oil or fried food consumption and weight change, incident overweight/obesity, type 2 diabetes, the metabolic syndrome, hypertension or CVD (Mean values and standard deviations)
HPFUS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; NR, not reported, T2DM, type 2 diabetes mellitus.
Table 3 Results for association between vegetable oil or fried food consumption and weight change, incident overweight/obesity, type 2 diabetes, the metabolic syndrome, hypertension or CVD reported by the twenty-three epidemiological studies (Odds ratios, hazard ratios or β-coefficients and 95 % confidence intervals)
NA, not applicable; NR, not reported; T2DM, type 2 diabetes mellitus; RR, relative risk; RCT, randomised controlled trial; MedDiet, Mediterranean diet; HR, hazard ratio.
Vegetable oil and fried food consumption was measured using FFQ (in the majority of the studies), dietary history questionnaire(Reference Guallar-Castillón, Rodríguez-Artalejo and Lopez-Garcia22, Reference Buckland, Travier and Barricarte23) or 24 h dietary recall(Reference Samieri, Feart and Proust-Lima31). Dietary intake information was updated in seven studies(Reference Mozaffarian, Hao and Rimm9, Reference Taveras, Berkey and Rifas-Shiman10, Reference Halton, Willett and Liu14–Reference Salas-Salvado, Bullo and Babio16, Reference Salas-Salvado, Bullo and Estruch18, Reference Estruch, Ros and Salas-Salvado25) by repeated measurements of dietary intake using the FFQ during the follow-up period (Table 1).
A summary of the results discussed in the review is shown in Fig. 2.
Fig. 2 OR/HR and 95 % CI for the fully adjusted model in the studies included in the present systematic review. * Fried food consumption as exposure. † Olive oil consumption as exposure. ‡ Sunflower oil consumption as exposure. § Palm oil consumption as exposure.
Association between vegetable oil or fried food consumption and weight gain or the risk of overweight/obesity
A total of five cohort studies(Reference Mozaffarian, Hao and Rimm9–Reference Sayon-Orea, Bes-Rastrollo and Basterra-Gortari13) that investigated the association between vegetable oil or fried food consumption and weight gain or the risk overweight/obesity were included in the present systematic review. Fried food consumption was found to be positively associated with the risk of becoming overweight/obese, as well as with a greater weight gain(Reference Mozaffarian, Hao and Rimm9, Reference Taveras, Berkey and Rifas-Shiman10, Reference Sayon-Orea, Bes-Rastrollo and Basterra-Gortari13). On the other hand, high consumption of olive oil was found to be not associated with a higher risk(Reference Bes-Rastrollo, Sánchez-Villegas and De la Fuente11), and a negative association was even reported by some studies(Reference Haro-Mora, García-Escobar and Porras12).
The most relevant results in this context were from the study of Mozaffarian et al. (Reference Mozaffarian, Hao and Rimm9), which using data of three separate large US cohorts investigated the relationship between multiple dietary changes including fried food consumption and long-term weight gain. The following three cohorts were included in this study: (1) the Nurses’ Health Study (NHS): a prospective cohort study of 121 701 female registered nurses enrolled in 1976; (2) the NHS-II: a prospective cohort study of 116 686 younger female registered nurses enrolled in 1989; (3) the Health Professionals Follow-up Study (HPFUS): a prospective cohort study of 51 529 male health professionals enrolled in 1986. All cohort participants were followed up using mailed questionnaires every 2 years. In total, 50 422 women from the NHS, 47 898 women from the NHS-II and 22 557 men from the HPFUS were found to be eligible, thereby 120 877 US women and men, all free of obesity and chronic diseases at baseline and who had complete data on weight and lifestyle habits, were included in the study. The relationship between changes in lifestyle factors and weight change was evaluated every 4 years. The dietary factors with the largest positive association with weight change/serving per d were increases in the consumption of potato chips and French fries (weight change after 4 years was 1·69, 95 % CI 1·30, 2·09 lb, and 3·35, 95 % CI 2·29, 4·42 lb, respectively). Fried food consumption at home and away from home was also found to be significantly associated with weight gain (0·39 lb, 95 % CI 0·22, 0·51 and 0·28 lb, 95 % CI 0·08, 0·48 respectively).
The ‘Seguimiento Universidad de Navarra’ (SUN) study assessed the association between fried food consumption and weight gain in a sample of 9850 participants with a mean age of 38·1 (sd 11·4) years who were followed up for a median time period of 6·1 years(Reference Sayon-Orea, Bes-Rastrollo and Basterra-Gortari13). Fried food consumption was found to be not significantly associated with a higher weight gain (β-regression coefficient = +46, 95 % CI, − 17,+109 g; P for trend = 0·230) on comparing the highest (>4 times/week) v. the lowest ( < 2 times/week) category of consumption. The risk of overweight/obesity was also analysed in this study in a sample of 6821 participants initially free of overweight/obesity at baseline, and during the same follow-up period, 1068 incident cases were identified, and higher consumption of fried foods was found to be associated with a significantly higher risk of becoming overweight/obese (OR 1·37, 95 CI% 1·08, 1·73; P for trend = 0·021) when comparing the highest (>4 times/week) v. the lowest ( < 2 times/week) category of consumption. In this study, analyses stratified by the type of oil used for frying were also conducted, in which it was found that those who used olive oil for frying tended to gain less weight and had a lower risk of becoming overweight/obese; however, none of these associations was found to be statistically significant. The results of this study supported the hypothesis that a high frequency of fried food consumption was associated with the risk of becoming overweight/obese among young adults in a Spanish cohort with a high educational level.
The possibility that frying with olive oil might be healthier and could be considered as a preferable substitute for frying with other oils deserves further assessments(Reference Soriguer, Esteva and Rojo Martinez32).
Some authors have shown that the impact of fried food consumption on body weight does not depend on the place where fried foods are prepared (home or away from home)(Reference Mozaffarian, Hao and Rimm9), with fried foods being prepared both at home and away from home being found to increase the risk of overweight/obesity. Therefore, it is assumed that the frying process (pan-frying or deep-frying, number of frying sessions, duration and temperature of frying, etc.) is not a determinant of body weight increase. However, most of the literature regarding the health effects of frying foods on overweight/obesity does not take into account specific aspects of the frying process, and it is well known that the frying technology can affect both the quality and the amount of fats consumed(Reference Ansorena, Guembe and Mendizabal33). Among the oils used for cooking, olive oil is less prone to oxidation(Reference Cahill, Pan and Chiuve34) and it maintains its health-beneficial properties, even after being cooked due to its thermal stability. It has even been shown that the antioxidants in frying oils (natural or added) might protect against postprandial oxidative stress in obese individuals(Reference Perez-Herrera, Rangel-Zuniga and Delgado-Lista35).
Furthermore, during cooking, molecular interactions occur between oil compounds and the different foods cooked. Oil becomes part of the product(Reference Flores-Alvarez Mdel, Molina-Hernandez and Hernandez-Raya36) and can therefore alter other food components during cooking, being able to increase or decrease the health and protective effects of some cooked foods. An exchange of lipid compounds between the oil used for frying and the food (fish) being fried has been demonstrated, although it depends on the fat content of the raw food. Furthermore, both the type of fish and the type of oil were found to influence the oxidation status of the lipid fraction. Ansorena et al. (Reference Ansorena, Guembe and Mendizabal33) found that the type of oil used for frying significantly affected the nutritional quality of low-fat fish than that of fatty fish as they absorb more fat. Zotos et al. (Reference Zotos, Kotaras and Mikras37) found frying foods in olive oil to lead to milder changes in the lipid profile compared with frying them in sunflower oil. They found a complete change in the fatty acid profile of anchovy samples, but the beneficial fatty acids EPA and DHA and the n-3:n-6 ratio remained at satisfactory levels. They found a high reduction in the concentrations of fish beneficial fatty acids and a tremendous reduction of the n-3:n-6 ratio when sunflower oil was used for frying. Frying in olive or sunflower oil was found to reduce cholesterol concentrations and significantly increase squalene (an antioxidant intermediate in cholesterol biosynthesis) concentrations, particularly when using olive oil(Reference Zotos, Kotaras and Mikras37). Naseri et al. (Reference Naseri, Abedi and Mohammadzadeh38) reported a decrease in the food n-3 fatty acid content and an increase in the n-6 content as a consequence of the migration of fatty acids from fish to the frying oil. Flores-Alvarez et al. (Reference Flores-Alvarez Mdel, Molina-Hernandez and Hernandez-Raya36) also showed that the type of fried food influences the oil used for frying: oil degradation was found to be faster for fish nuggets than for French fries, and this degradation may influence the oil content of the specific food type fried. This oil uptake has been shown to differ depending on the frying time or pressure(Reference Pawar, Boomathi and Hathwar39). When extra-virgin olive oil is used for frying French fries, fish or different vegetables, oil absorption occurs and the food absorbs antioxidant compounds that get enriched with polyphenols.
Association between vegetable oil or fried food consumption and the risk of type 2 diabetes or the metabolic syndrome
A total of four cohort studies(Reference Halton, Willett and Liu14, Reference Lutsey, Steffen and Stevens15, Reference Mari-Sanchis, Beunza and Bes-Rastrollo17, Reference Sayon-Orea, Martinez-Gonzalez and Gea19) and two studies(Reference Salas-Salvado, Bullo and Babio16, Reference Salas-Salvado, Bullo and Estruch18) analysing the results of the PREDIMED (Prevención con Dieta Mediterránea) study, a randomised controlled trial, that assessed the association between vegetable oil or fried food consumption and the risk of T2DM or the MetS were included in the present systematic review. Fried food consumption was found to be directly associated with the risk of T2DM(Reference Halton, Willett and Liu14) and the MetS(Reference Lutsey, Steffen and Stevens15). However, the results of the SUN study indicated no association between fried food consumption and the risk of the MetS(Reference Sayon-Orea, Martinez-Gonzalez and Gea19). The PREDIMED study found an inverse association between olive oil consumption and the risk of T2DM(Reference Salas-Salvado, Bullo and Babio16, Reference Salas-Salvado, Bullo and Estruch18), while the SUN study did not find any association between olive oil consumption and the risk of T2DM(Reference Mari-Sanchis, Beunza and Bes-Rastrollo17).
The PREDIMED study is a parallel-group, multi-centre, randomised trial that included 7447 participants (men aged 55–80 years; women aged 60–80 years) with no CVD at enrolment, who had either T2DM or at least three of the following major risk factors: smoking; hypertension; elevated LDL-cholesterol concentrations; low HDL-cholesterol concentrations; overweight or obesity; a family history of premature CHD(Reference Martinez-Gonzalez, Corella and Salas-Salvadó40). The participants were randomly assigned, at a 1:1:1 ratio, to one of the following three dietary intervention groups: a Mediterranean diet supplemented with extra-virgin olive oil (free provision of 1 litre/week for the participant and his/her family); a Mediterranean diet supplemented with nuts (a free 30 g/d provision of walnuts, hazelnuts and almonds); a control low-fat diet. The principal aim of this study was to assess the association between adherence to the Mediterranean diet and cardiovascular risk; however, secondary outcomes such as T2DM were also assessed. As part of the intervention, the participants randomly allocated to the two Mediterranean diet groups were advised (on a quarterly basis) to exclusively use olive oil for culinary purposes, including for frying. Salas-Salvado et al. (Reference Salas-Salvado, Bullo and Babio16) analysing only one participating centre of those included in the PREDIMED study and excluding participants with T2DM at baseline found that a Mediterranean diet supplemented with olive oil in comparison with the control diet reduced the risk of T2DM (HR 0·49; 95 % CI 0·25, 0·97), and they reported that the possible biological mechanism responsible for this effect might be the anti-inflammatory properties of the virgin olive oil that might be relevant to the reduction of the risk of T2DM. Recently, the PREDIMED investigators have published the results regarding T2DM, but using data from all the centres(Reference Salas-Salvado, Bullo and Estruch18). A total of 3541 patients free of T2DM at baseline were included, and participants in the group of Mediterranean diet supplemented with olive oil were found to exhibit a significantly lower risk of developing new-onset T2DM after the follow-up period (HR 0·60; 95 % CI 0·43, 0·85).
The next outcome that was analysed in the present systematic review was the MetS as an ancillary component to complement the results obtained for T2DM. The MetS is a constellation of metabolic abnormalities that increase the risk of heart disease and T2DM(Reference Wilson, D'Agostino and Parise41). These metabolic abnormalities include hypertriacylglycerolaemia, low HDL-cholesterol concentrations, elevated blood pressure, impaired glucose metabolism and central obesity(Reference Grundy, Brewer and Cleeman42). The data of 8289 participants initially free of any MetS criterion were analysed in the SUN study and the participants were followed up for a median time period of 8·3 years. The mean age of the participants was 35·9 (sd 10·4) years. This study concluded that frequent consumption of fried foods was not associated with the incidence of the MetS (HR 0·93; 95 % CI 0·72, 1·20; P for trend = 0·538) by comparing the highest (>4 times/week) v. the lowest ( < 2 times/week) category of consumption. However, two of the five components of the MetS, namely central adiposity and high blood pressure, were found to be positively associated with fried food consumption (HR 1·09; 95 % CI 1·00, 1·18; P for trend = 0·040, and HR 1·18; 95 % CI 1·04, 1·34; P for trend = 0·017, respectively) when comparing the highest v. the lowest category of consumption after multivariable adjustment. In the same study, a higher (but not statistically significant) risk of developing the MetS was observed among participants in the highest category of fried food consumption and who used fats other than olive oil for frying (HR 1·26; 95 % CI 0·71, 2·23; P for trend = 0·446). The risk of developing the MetS among those in the highest category of consumption but who used olive oil for frying was lower (HR 0·85; 95 % CI 0·63, 1·15; P for trend = 0·284). Therefore, it might be possible that different types of oils used for frying may have different effects that could explain these findings(Reference Sayon-Orea, Martinez-Gonzalez and Gea19). In this context, as a part of the Pizarra study(Reference Soriguer, Esteva and Rojo Martinez32), it was assessed whether insulin resistance was cross-sectionally associated with cooking oils. Samples of cooking oil being used were obtained from the kitchen of 538 subjects, and after administration of 75 g of glucose, oral glucose tolerance tests were conducted. The results of this study showed that the levels of insulin resistance were significantly lower in subjects who used olive oil for frying than in those who used sunflower or a mixture of several oils.
The possible biological mechanism could be explained by the fact that olive oil can reduce the glycaemic load of a meal, decreasing carbohydrate absorption rate, insulin secretion and lipogenesis. MUFA appear to be powerful stimulators of Glucagon-like peptide-1 (GLP1) secretion after an olive oil-enriched meal, leading to better insulin sensitivity(Reference Haro-Mora, García-Escobar and Porras12).
Association between vegetable oil or fried food consumption and the risk of CVD
A total of seven cohort studies(Reference Mozaffarian, Lemaitre and Kuller20–Reference Sayon-Orea, Bes-Rastrollo and Gea24, Reference Bendinelli, Masala and Saieva30, Reference Samieri, Feart and Proust-Lima31), four case–control studies(Reference Rastogi, Reddy and Vaz26–Reference Kontogianni, Panagiotakos and Chrysohoou29) and one randomised controlled trial study(Reference Estruch, Ros and Salas-Salvado25) that investigated the association between vegetable oil or fried food consumption and the risk of CVD were included in the present systematic review. The most relevant finding in this context was the contribution of the PREDIMED study; this study concluded that a Mediterranean diet supplemented with extra-virgin olive oil led to a relative 30 % risk reduction in the incidence of major cardiovascular events among individuals at high cardiovascular risk. The PREDIMED intervention study recommended the use of olive oil for frying in the two active arms of the trial.
In contrast, in some observational studies, fried food consumption was found to be directly associated with a higher risk of CVD(Reference Mozaffarian, Lemaitre and Kuller20) and hypertension(Reference Sayon-Orea, Bes-Rastrollo and Gea24), whereas olive oil consumption(Reference Buckland, Travier and Barricarte23, Reference Kontogianni, Panagiotakos and Chrysohoou29–Reference Samieri, Feart and Proust-Lima31), use of vegetable oils(Reference Lockheart, Steffen and Rebnord28) and mustard oil consumption(Reference Rastogi, Reddy and Vaz26) were found to be inversely associated with the risk of CVD. However, palm oil consumption was reported to be positively associated with the risk of CVD(Reference Kabagambe, Baylin and Ascherio27). Olive oil consumption was also reported to be inversely associated with the risk of hypertension(Reference Alonso and Martinez-Gonzalez21).
The European Prospective Investigation into Cancer and Nutrition (EPIC) is a cohort study of 520 000 European men and women that aimed to assess the impact of dietary, lifestyle and genetic factors on the risk of cancer and other chronic conditions. EPIC-Spain is a part of this large European cohort study and comprised 41 440 participants.
The association between fried food consumption and the risk of CHD was investigated in the EPIC-Spain. A total of 40 757 healthy adults were included in this study. During a median follow-up period of 11 years, 606 incident cases of CHD were identified. The multivariate HR for the fourth (highest) quartile compared with the first (lowest) quartile of fried food consumption was 1·08 (0·82, 1·43; P for trend = 0·74). The results of this study did not vary when stratified by the type of oil used for frying (olive oil/sunflower oil). In this study, only olive oil and sunflower oil were evaluated; therefore, authors admitted that they cannot dismiss that frying with other types of fats may still be harmful(Reference Guallar-Castillón, Rodríguez-Artalejo and Lopez-Garcia22).
The association between fried food consumption and the risk of hypertension was investigated in the SUN cohort, including data of 13 679 participants (5059 men and 8620 women) free of hypertension at baseline. The mean age of the participants was 36·5 (sd 10·8) years. During a median follow-up period of 6·3 years, 1232 incident cases of hypertension were identified. The adjusted HR for developing hypertension among participants with a higher frequency of baseline fried food consumption (>4 times/week) was 1·21 (95 % CI 1·04, 1·41) compared with those in the lowest category of consumption ( < 2 times/week) (P for trend = 0·020)(Reference Sayon-Orea, Bes-Rastrollo and Gea24). This result was consistent with that of a cross-sectional study conducted in 538 participants, in which the association between fried food consumption (specifically of reused vegetable oils) and the prevalence of hypertension was evaluated. The results showed that degradation due to the reuse of vegetable oils, especially sunflower oil, was an independent risk factor for hypertension and interestingly the serum concentration of MUFA was found to be negatively associated with this risk(Reference Soriguer, Esteva and Rojo Martinez32).
The Cardiovascular Heart Study (CHS) is a population-based, longitudinal study of CHD and stroke that included participants aged ≥ 65 years. This study was designed to identify factors related to the onset and course of CHD and stroke, specifically to determine the importance of conventional cardiovascular risk factors in older adults and to identify new risk factors in this age group, especially those that may be protective and modifiable(Reference Fried, Borhani and Enright43). In this context, Mozaffarian et al. (Reference Mozaffarian, Lemaitre and Kuller20) tested the hypothesis that fried fish consumption could be inversely associated with fatal CHD. This study was conducted in 3910 adults free of known CVD at baseline with a mean age of 72 years. Over a mean follow-up period of 9·3 years, 247 fatal CHD cases and 363 incident non-fatal myocardial infarction cases were identified. The consumption of tuna or other broiled or baked fish was found to be associated with a lower risk of total CHD deaths among individuals consuming tuna/other fish ≥ 3 times/week than among those consuming tuna/other fish < 1 time/month (HR 0·47; 95 % CI 0·27, 0·82; P for trend = 0·002), and contrarily, fried fish consumption was found to be not associated with a lower risk of total CHD deaths (HR 1·37; 95 % CI 0·48, 3·90; P for trend = 0·35) or non-fatal myocardial infarctions (HR 1·93; 95 % CI 0·91, 4·08; P for trend = 0·11), but rather to be associated with trends towards a higher risk. Mozaffarian et al. (Reference Mozaffarian, Lemaitre and Kuller20) concluded that cardiac benefits of fish consumption vary, according to the type of fish consumed.
The frying process has been reported to increase the hypocholesterolaemic:hypercholesterolaemic fatty acid ratio and reduce the n-3:n-6 ratio(Reference Hosseini, Mahmoudzadeh and Rezaei44). In addition, Naseri et al. (Reference Naseri, Abedi and Mohammadzadeh38) also found that although frying led to a reduction of the n-3:n-6 content in olive oil, the reduction was not high. Vegetable oils contain high quantities of n-6 PUFA mainly as linoleic acid. The increase in the consumption of linoleic acid-rich oils (e.g. soyabean oil and sunflower oil) is even associated with a decreased n-3 long-chain PUFA content in human body tissue. An increased intake of vegetable oils (via excessive use in food processing) characterises high quantities of n-6 PUFA and a deficit in n-3 PUFA(Reference Strobel, Jahreis and Kuhnt45). Strobel et al. (Reference Strobel, Jahreis and Kuhnt45) found that fish processing methods (breading and frying in vegetable oils) had a negative effect, increasing the linoleic acid content and decreasing the n-3:n-6 ratio.
Lipid oxidation is much faster in cooked foods than in fresh foods because cooking accelerates oxidation(Reference Pawar, Boomathi and Hathwar39). Olive oil has been reported to confer cardiometabolic health benefits when used for frying. However, in general, frying increases the amounts of cholesterol oxidation products and reduces the activity of paraoxonase, which is an enzyme that inhibits the oxidation of LDL-cholesterol(Reference Cahill, Pan and Chiuve34). High concentrations of phenolic compounds in olive oil have protective effects against CVD(Reference Franco, Galeano-Diaz and Lopez46).
Conclusions
From the results of the studies included in this review, we conclude that (1) the myth that frying foods is generally associated with a higher risk of CVD is not supported by the available evidence; (2) extra-virgin olive oil significantly reduces the risk of CVD clinical events and weight gain, based on the results of a large randomised trial that included as part of the intervention the recommendation to use large amounts of extravirgin olive oil for culinary purposes, also for frying foods; however, the whole Mediterranean dietary pattern plays a more significant role rather than the supplemental extra-virgin olive oil alone; and (3) high consumption of fried foods is probably related to a higher risk of weight gain and hypertension. However, many factors such as the type of oil used and the frying technique (deep-frying or panfrying), frying duration and temperature, and use of new or reused oils for frying have to be taken into account.
The authors' contributions were as follows: MAM-G was responsible for the initial plan and study design, CS-O was responsible for the data collection, data extraction; MAM-G, SC, and CS-O were responsible for the data interpretation, manuscript drafting, critical revision of intellectual content and approval of the final version of the manuscript.
Acknowledgements
None of the authors has any conflicts of interest to declare.
