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Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients*

Published online by Cambridge University Press:  09 March 2007

Marianne Payet ,
Mohamed H. Esmail ,
Elisabeth Polichetti ,
Gaël Le Brun ,
Lounès Adjemout ,
Gérard Donnarel ,
Henri Portugal  and
Gérard Pieroni
Marianne Payet
Affiliation:
I.N.S.E.R.M. U476, Faculté de Médecine, 27 Bd Jean Moulin, 13385, Marseille, cedex 05, France
Mohamed H. Esmail
Affiliation:
I.N.S.E.R.M. U476, Faculté de Médecine, 27 Bd Jean Moulin, 13385, Marseille, cedex 05, France
Elisabeth Polichetti
Affiliation:
GLON SANDERS, Pontivy, France
Gaël Le Brun
Affiliation:
GLON SANDERS, Pontivy, France
Lounès Adjemout
Affiliation:
Centre Gérontologique Départemental, Marseille, France
Gérard Donnarel
Affiliation:
Centre Gérontologique Départemental, Marseille, France
Henri Portugal
Affiliation:
I.N.S.E.R.M. U476, Faculté de Médecine, 27 Bd Jean Moulin, 13385, Marseille, cedex 05, France
Gérard Pieroni*
Affiliation:
I.N.S.E.R.M. U476, Faculté de Médecine, 27 Bd Jean Moulin, 13385, Marseille, cedex 05, France
*
†Corresponding author: Dr Gérard Pieroni, fax +33 4 91 78 21 01, email [email protected]
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Abstract

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Many studies in humans volunteers have shown that dietary docosahexaenoic acid (DHA) supplied as triacylglycerol can increase DHA levels in blood lipids but often strongly decreases those of arachidonic acid (AA). The aim of the present study was to determine the effect of dietary supplementation with egg-yolk powder enriched in DHA, corresponding to the French recommended dietary allowance for DHA, on the blood lipid status of an elderly population. Institutionalised elderly individuals aged between 63 and 93 years consumed an egg product enriched in DHA (150 mg/d) once daily for 9 months. Plasma lipids and the fatty acid composition of erythrocyte membranes were determined every 3 months. The supplementation induced an increase in the PUFA content of plasma and erythrocyte membranes which was +14·5 and +25·3 %, respectively, at 9 months. This effect was mainly due to the level of DHA and, unexpectedly, to that of AA which continuously increased. This increase in AA was the result of an increased dietary intake (+50 mg/d) and very probably of an increased biosynthesis as demonstrated by the behaviour of di-homo-γ-linolenic acid. The supplementation resulted in a blood PUFA status comparable with that of young healthy controls. The data are consistent with a strong regulatory action of the dietary treatment on the subjects' lipid metabolism.

Keywords

Docosahexaenoic acidArachidonic acidEnriched egg yolkElderly
Type
Research Article
Information
British Journal of Nutrition , Volume 91 , Issue 5 , May 2004 , pp. 789 - 796
Copyright
Copyright © The Nutrition Society 2004

Footnotes

*

Presented as an oral communication at ISSFAL Fifth Congress, 7–11 May 2002, Montreal, Canada.

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