Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-25T04:42:03.315Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice

Published online by Cambridge University Press:  09 March 2007

Francine Bourgeois ,
Andre Alexiu  and
Daniel Lemonnter
Francine Bourgeois
Affiliation:
Unité de Recherches sur la Nutrition et l'Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75018 Paris, France
Andre Alexiu
Affiliation:
Unité de Recherches sur la Nutrition et l'Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75018 Paris, France
Daniel Lemonnter
Affiliation:
Unité de Recherches sur la Nutrition et l'Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75018 Paris, France
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Male and female mice, 4 weeks old, were fed ad lib. diets containing various amounts of lard (0–300 g/kg) or various kinds of dietary fats (300 g/kg) for 13 weeks. Fat cell number and size were determined by a histological method in three different adipose sites.

2. Lard at 200 g/kg diet (43% energy from lipids) was sufficient to promote fat cell hyperplasia in the parametrial fat. Hyperplasia was also observed in the subcutaneous fat in males. The relationship between fat cell hypertrophy and the level of lard in the diet was dependent on site and sex.

3. Obesity was produced whatever the kind of dietary fat eaten: lard, beef tallow, sunflower oil or soya-bean oil. In the subcutaneous depot of males given lard, fat cell size and number were increased, but only cell hypertrophy was observed in those given soya-bean oil. In the female groups of mice fat cell hyperplasia or hypertrophy or both were related to the adipose site but not the kind of dietary fat.

4. It is concluded that dietary fats of different origin can induce obesity in mice. The effects on adipose tissue cellularity depend on the levels and kind of fat eaten, the adipose site and sex.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 49 , Issue 1 , January 1983 , pp. 17 - 26
Copyright
Copyright © The Nutrition Society 1983

References

Barboriak, J. J., Krehl, W. A., Cowgill, G. R. & Whedon, A. D. (1958). J. Nutr. 64, 241.CrossRefGoogle Scholar
Bjurulf, P. (1959). Acta Med. Scand. 166, (suppl.), 349.Google Scholar
Cryer, A., Kirtland, J., Jones, H. M. & Gurr, M. I. (1978). Biochem. J. 170, 169.CrossRefGoogle Scholar
De Gasquet, P. & Péquignot, E. (1974). In The Regulation of Adipose Tissue Mass, p. 47 [Vague, J. and Boyer, J., editors]. Amsterdam: Excerpta Medica.Google Scholar
Dryden, L. P., Foley, J. B., Gleis, P. F. & Hartman, A. M. (1956). J. Nutr. 58, 189.CrossRefGoogle Scholar
Faust, I. M., Johnson, P. R., Stern, J. S. & Hirsch, J. (1978). Am. J. Physiol. 235, E279.Google Scholar
Fenton, P. F. & Carr, J. C. (1951). J. Nutr. 45, 225.CrossRefGoogle Scholar
Häger, A., Sjöstrom, L., Arvidsson, B., Björntorp, P. & Smith, U. (1977). Metabolism 6, 607.CrossRefGoogle Scholar
Herberg, L., Döppen, W., Major, E. & Gries, F. A. (1974). J. Lipid Res. 15, 580.CrossRefGoogle Scholar
Hirsch, J. & Han, P. W. (1969). J. Lipid Res. 10, 77.CrossRefGoogle Scholar
Kirtland, J. & Gurr, M. I. (1978). Br. J. Nutr. 39, 19.CrossRefGoogle Scholar
Klyde, B. J. & Hirsch, J. (1979). J. Lipid Res. 20, 705.CrossRefGoogle Scholar
Kral, J. G. (1976). Am. J. Physiol. 231, 1090.CrossRefGoogle Scholar
Lemonnier, D. (1972). J. clin. Invest. 51, 2907.CrossRefGoogle Scholar
Lemonnier, D. (1981). In Adipose Tissue Development in Normal and Obese Animals, p. 57 [Bonnet, F. P., editor]. Cleveland, Ohio: CRC Press.Google Scholar
Lemonnier, D. & Alexiu, A. (1974). In The Regulation of Adipose Tissue Mass, p. 158 [Vague, J. and Boyer, J., editors]. Amsterdam: Excerpta Medica.Google Scholar
Lemonnier, D., Alexiu, A. & Lanteaume., M. T. (1973). J. Physiol., Paris. 66, 729.Google Scholar
Lemonnier, D., Suquet, J. P., Aubert, R., De Gasquet, P. & Péquignot, E. (1975). Diab. Metab, Paris. 1, 77.Google Scholar
Mayer, J. (1970). In Anorexia and Obesity, p. 255 [Rowland, C. V., editor]. Boston: Little, Brown.Google Scholar
Miller, D. S. (1979). In Animal Models of Obesity, p. 131 [Festing, M. F. W., editor]. London: Macmillan Press.CrossRefGoogle Scholar
Pascal, G., Durand, G., Macaire, J. P. & Penot, E. (1977). Annls. Biol. Anim. Biochem. Biophys. 17, 827.CrossRefGoogle Scholar
Pawar, S. S. & Tidwell, H. C. (1968a). J. Lipid Res. 9, 334.CrossRefGoogle Scholar
Pawar, S. S. & Tidwell, H. C. (1968b). Biochem. biophys. Acta 164, 167CrossRefGoogle Scholar
Raulin, J., Loriette, C., Launay, M., Lapous, D., Goureau-Counis, M. F., Counis, R. & Carreau, J. P. (1974). In The Regulation of the Adipose Tissue Mass, p. 32 [Vague, J. and Boyer, J., editors]. Amsterdam: Excerpta Medica.Google Scholar
Schemmel, R., Mikelsen, O. & Gill, J. L. (1970). J. Nutr. 100, 1041.CrossRefGoogle Scholar
Yukimura, Y. & Bray, G. (1978). Endocr. Res. Com. 5, 189.CrossRefGoogle Scholar