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Dietary n-6:n-3 fatty acid ratio in the perinatal period affects bone parameters in adult female rats

Published online by Cambridge University Press:  09 March 2007

M. Korotkova ,
C. Ohlsson ,
L. Å. Hanson  and
B. Strandvik
M. Korotkova*
Affiliation:
Department of Pediatrics, Göteborg University, SE 41685 Göteborg, Sweden
C. Ohlsson
Affiliation:
Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Göteborg University, Göteborg, Sweden
L. Å. Hanson
Affiliation:
Department of Clinical Immunology, Göteborg University, Göteborg, Sweden
B. Strandvik
Affiliation:
Department of Pediatrics, Göteborg University, SE 41685 Göteborg, Sweden
*
*Corresponding author: Dr Marina Korotkova, fax +46 31 21 70 23, email [email protected]
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Abstract

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PUFA and their metabolites are important regulators of bone formation and resorption. The effect of PUFA on bone growth may be especially striking during the perinatal period. The aim of the present study was to investigate the effect of diets with different n-6:n-3 fatty acid (FA) ratios during the perinatal period on bone parameters in the adult offspring. During late gestation and throughout lactation, rat dams were fed an isoenergetic diet containing 70 g linseed oil (n-3 diet), soyabean oil (n-6+n-3 diet) or sunflower-seed oil (n-6 diet) per kg with n-6:n-3 FA ratios of 0·4, 9 and 216, respectively. The offspring were weaned onto an ordinary chow and followed until 30 weeks of age. Bone parameters were analysed using peripheral quantitative computerised tomography and dual-energy X-ray absorptiometry. Femur length and cortical cross-sectional bone area and bone mineral content were significantly higher in the n-6+n-3 group than in the other groups. Cortical bone thickness in the n-6+n-3 group was increased compared with the n-3 group, but most cortical bone parameters did not differ between the n-3 and n-6 groups. The results suggest that regulatory mechanisms were influenced by the n-6:n-3 FA ratio early in life and not compensated for by the introduction of an ordinary diet after weaning.

Keywords

DietBone mineral densityFatty acidsInsulin-like growth factor-1
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue 4 , October 2004 , pp. 643 - 648
Copyright
Copyright © The Nutrition Society 2004

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