Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-23T02:19:39.637Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary level of maize oil affects growth and lipid composition of Walker 256 carcinosarcoma

Published online by Cambridge University Press:  09 March 2007

J. Mark Black ,
Malden C. Nesheim  and
John E. Kinsella
J. Mark Black
Affiliation:
Lipids Research Group, Cruess Hall, University of California, Davis, California 95616, USA
Malden C. Nesheim
Affiliation:
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
John E. Kinsella
Affiliation:
Lipids Research Group, Cruess Hall, University of California, Davis, California 95616, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Walker 256 carcinosarcoma cells (1 × 104) were injected into the right thigh muscle of Sprague–Dawley rats (125 g) consuming isoenergetic (200 g fat/kg) diets containing 20, 100 and 200 g maize oil/kg and 180, 100 or 0 g hydrogenated lard/kg respectively. Ten rats from each dietary regimen were killed every 4th day. Tumours grew rapidly from day 0 to day 8 post-transplant regardless of dietary regimen. However, after 8 d more tumours regressed and there were fewer deaths in animals fed on 200 g maize oil/kg compared with animals fed on 20 or 100 g maize oil/kg. Linoleic acid (LA) levels were higher in phospholipids (PL) of growing tumours than in regressing tumours whereas arachidonic acid levels in PL were lower in growing tumours indicating a possible alteration in the desaturation and elongation of LA. Serum prostaglandin E2 levels were slightly lower in rats with regressing tumours than in rats with growing tumours.

Keywords

Linoleic acidCancerLipidsWalker 256 carcinosarcomaGrowth
Type
Dietary Lipid Growth of a Carcinosarcoma
Information
British Journal of Nutrition , Volume 71 , Issue 2 , February 1994 , pp. 283 - 294
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

American Institute of Nutrition (1977). Report of the AIN adHoc Committee on standards for nutritional studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
Bailey, J. M. & Dunbar, L. M. (1971). Lipid metabolism in cultured cells. Growth of tumor cells deficient in essential fatty acids. Cancer Research 31, 91–97.Google ScholarPubMed
Bang, H. O., Dyerberg, J. & Hjorne, N. (1976). The composition of food consumed by Greenland Eskimos. Acta Medica Scandinavica 200, 69–73.CrossRefGoogle ScholarPubMed
Berg, J. W. (1975). Can nutrition explain the pattern of international epidemiology of hormone-dependent cancers? Cancer Research 35, 3345–3350.Google ScholarPubMed
Brenner, R. R. (1984). Effect of unsaturated fatty acids on membrane structure and enzyme kinetics. Progress in Lipid Resarch 23, 69–96.CrossRefGoogle ScholarPubMed
Bruckner, G., Trimbo, S. & Kinsella, J. E. (1983). Dietary trilinoelaidate: effects on hematological parameters, serum eicosanoids and tissue fatty acids in rats. Journal of Nutrition 113, 704–713.CrossRefGoogle ScholarPubMed
Cbo-Chung, Y.S. (1974). In viva inhibition of tumor growth by cyclic adenosine 3′,5′-monophosphate derivatives. Cancer Research 34, 3492–3496.Google Scholar
Cho-Chung, Y. S. & Berghoffer, B. (1974). The role of cyclic AMP in neoplastic cell growth and regression. II. Growth arrest and glucose-6 phosphate dehydrogenase isozyme shift by dibutyryl cyclic AMP. Biochmical Biophysical Research Communications 60, 528–534.CrossRefGoogle ScholarPubMed
Cho-Chung, Y. S. & Clair, T. (1977). Altered cyclic AMP-binding and db-cyclic AMP-unresponsiveness in vivo. Nuture 256, 452–454.CrossRefGoogle Scholar
Cho-Chung, Y. S. & Gullino, P. M. (1973). Effects of dibutyryl cyclic adenosine 3′,5′ monophosphate on in vivo growth of Walker 256 carcinoma: isolation of responsive and unresponsive cell populations. Journal of the National Cancer Institute 52, 995–996.CrossRefGoogle Scholar
Cho-Chung, Y. S. & Gullino, P. M. (1974). In vivo inhibition of growth of two hormone-dependent mammary tumors by dibutyryl cyclic AMP. Science 183, 87–88.CrossRefGoogle ScholarPubMed
Chow, Fi, & Omaye, T T. (1983). Use of antioxidants in the analysis of vitamins A and E in mammalian plasma by high-performance liquid chromatography. Lipids 18, 837–841.CrossRefGoogle Scholar
Christie, W. W. (1982). Lipid Ana1ysis. New York: Pergamon Press.Google Scholar
Cohen, L. A., Thompson, D. O..Maeurd. Y.,Choi, K.. Blank, M. E. & Rose, D. P. (1986). Dietary fat and mammary cancer. 1. Promoting effects of different dietary fats on N-nitrosomethylurea-inducedrat mammary tumorigenesis. Journal of the Natioinal Cancer Institute 77, 33–42.Google ScholarPubMed
Dills, W. L. Jr, Kwong, E., Covey, T. R. & Nesheim, M. C. (1984). Effects of diets deficient in glucose and glucose precursors on the growth of the Walker carcinosarcoma 256 in rats. Journal of Nutrition 114, 2097–2106.CrossRefGoogle ScholarPubMed
Doll, R., Muir, C. & Waterhouse, J. (1966). Cancer incidence in Five Continents. New York: Springer-Verlag.CrossRefGoogle Scholar
Emilson, A. & Sundler, R. (1985). Studies on the enzymatic pathways of calcium ionophore induced phospholipid degradation and arachidonic acid mobilization in peritoneal macrophages. biochemica Biophysica Acta 8461, 265–274.CrossRefGoogle Scholar
Gammal, E. B., Carroll, K. K. & Plunkett, E. R. (1967). ERects of dietary fat on mammary carcinogenesis 7,12 dimethylbenz(a)anthracene in rats. Cancer Research 27, 1737–1742.Google Scholar
Hillyard, L. A. & Abraham, S. (1979). Effect of dietary polyunsaturated fatty acids on growth of mammary adenocarcinomas in mice and rats. Cancer Research 39, 4430–4437.Google ScholarPubMed
Hopkins, G. J. & Carroll, K. K. (1979). Relationship between amount and type of dietary fat in promotion mammary carcinogenesis induced by 7, I2-dimethylbenz(a)anthracene. Journal of the National Cancer Institute 62. 1009–1012.Google Scholar
Hopkins, G. J., Kennedy, T. G. & Carroll, K. K. (1981). Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague-Dawley rats by 7,12-dimethylbenz(a)anthracene. Journal of the National Cancer institute 66, 517–522.Google Scholar
Horvath, P. M. & Ip, C. (1983). Synergistic effect of Vitamin E and selenium in the chemoprovention of mammary carcinogenesis in rats. Cancer Research 43, 5335–5341.Google Scholar
Karmali, R. A. (1980). Review: Prostaglandins and cancer. Prostuglmdiizs Leukorrienes uizd Medicine 5, 11–28.Google ScholarPubMed
Karmali, R. A., Marsh, J. & Fuchs, C. (1984). Effect of omega-3 fatty acids on growth of a rat mammary tumor Jourual of the National Cancer Institute 73, 457–461.CrossRefGoogle ScholarPubMed
Kinsella, J. E., Broughton, S. & Whelm, J. (1990). Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis. Journal of Nutrition Biochemistry,1, 123–141.CrossRefGoogle ScholarPubMed
Kinsella, J. E. & Lokesh, B. R. (1990). Dietary lipids; eicosanoids and immune system. Critical Care Medicine 18, 100–115.CrossRefGoogle Scholar
Krause, R., James, J. H., Humphrey, C. & Fischer, J. E. (1979). Plasma and brain amino acids in Walker 256 carcinosarcoma-bearing rats. Cancer Research 39, 3065–3069.Google ScholarPubMed
Kwong, E., Nesheim, M. C. & Dills, W. L. Jr (1984). The influences of diet on the regression of the Walker carcinosarcoma 256 in rats. Journal of Nutrition 114, 2324–2330.CrossRefGoogle ScholarPubMed
Lokesh, B. R., Hsieh, H. L. & Kinsella, J. E. (1986). Alterations in the lipids and prostaglandins of mouse spleens following the ingestion of menhadcn oil. Annals of Nutrition and Metabolism, 30, 357–364.CrossRefGoogle ScholarPubMed
Lokesh, B. R. & Kinsella, J. E. (1985). Lipid composition and prostaglandin synthesis in mouse lung microsomes: alterations following the ingestion of menhaden oil. Lipids 20, 842–849.CrossRefGoogle ScholarPubMed
Lokesh, B. R. & Kinsella, J. E. (1988). Cancer, dietary fats and polyunsaturated fatty acids. National Medica1 Journal of India 1, 281–288.Google Scholar
Maeda, M., Osamu, D. & Yuzuru, A. (1978). Metabolic conversion of polyunsaturated fatty acids in mammalian cultured cells. Biochemica et Biophysicai Acta 530, 153–164.Google ScholarPubMed
Morrison, S. S. (1972). Feeding response to change in absorbable food fraction during growth of Walker carcinosarcoma. Cancer Research 32, 968–972.Google Scholar
Nielsen, N. H. & Hansen, J. P. (1980). Breast cancer in Greenland –selected epidemiological, clinical histological features. Journal of Cancer Research ad Clinical Oneology 98, 287–299.CrossRefGoogle Scholar
O'Connor, T., Roebuck, B., Peterson, F., Lokesh, B. R., Kinsella, J. E. & Campbell, C. (1989). Effect of dietary ω-3and ω-6 fatty acids on development of azaserine induced preneoplastic lesions in rat pancreas. Journalof the National Cancer Instituie 81, 858–863.CrossRefGoogle Scholar
Owen, C. A. Jr (1982). Hypersensitivity to warfarin in rats with Walker 256 carcinosarcoma (41297). Proceedings of the National Academy of Sciences, USA 169, 1–3.Google Scholar
SAS Institute lnc. (1985). SAS User's Guide: Strrtistics, version 5 ed. Cary, NC: SAS Institute Inc.Google Scholar
Shimp, J. I., Bruckner, G. G. & Kinsella, J. E. (1982). The effects of dietary trilinoelaidin on fatty acid and acyl desaturases in rat liver. Journal of Nutrition 112, 722–735.CrossRefGoogle ScholarPubMed
Snedecor, G. W. & Cochran, W. G. (1980). Staistical Methods, Arnes, Iowa: The Iowa State University Press.Google Scholar
Swanson, J. E., Black, J. M. & Kinsella, J. E. (1987). Dietary 11–3 polyunsaturated fatty acids; rate and extent modification of fatty acyl composition of lipid classes of mouse lung and kidney. Journal of Nutrition 117, 824–832.CrossRefGoogle Scholar
Varani, J. & Perone, P. (1985). Response of Walker 256 carcinosarcoma cells to 12–0-tetrddecanoyl phorbol 13 acetate: possible regulation by endogenous cyclooxygenase metabolites. Journal of the National Cancer Institute 74, 165–172.Google ScholarPubMed