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Dietary fructose v. glucose in rats raises urinary excretion, true absorption and ileal solubility of magnesium but decreases magnesium retention

Published online by Cambridge University Press:  09 March 2007

Annet Van Der Heijden ,
Gerrit J. Van Den Berg ,
Arnoldlna G. Lemmens  and
Anton C. Beynen
Annet Van Der Heijden
Affiliation:
Department of Laboratory Animal Science, Utrecht University, 3508 TD Utrecht, The Netherlands
Gerrit J. Van Den Berg
Affiliation:
Interfaculty Reactor Institute, University of Technology, 2629 JB Delft, The Netherlands
Arnoldlna G. Lemmens
Affiliation:
Department of Laboratory Animal Science, Utrecht University, 3508 TD Utrecht, The Netherlands
Anton C. Beynen
Affiliation:
Department of Laboratory Animal Science, Utrecht University, 3508 TD Utrecht, The Netherlands
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Abstract

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Apparent Mg absorption, that is Mg intake minus faecal excretion, was found to be greater in rats fed on diets containing fructose instead of glucose. This effect of fructose was accompanied by enhanced urinary excretion and diminished retention of Mg. True Mg absorption was then determined with the use of oral and intraperitoneal administration of tracer doses of 28Mg. True Mg absorption was significantly greater in rats fed on fructose. There was no significant effect of fructose v. glucose on faecal excretion of endogenous Mg. It was hypothesized that fructose enhances the solubility of Mg in the ileal lumen and thereby facilitates its absorption. The distribution of Mg between the solid and liquid phases of the ileum was determined in rats fed on either glucose or fructose. Fructose reduced the amount of Mg in the solid phase but raised both the amount and the concentration of Mg in the liquid phase. We conclude that the dietary-fructose-induced stimulation of Mg absorption in rats is caused by a raised solubility of ileal Mg. but the mechanism by which fructose exerts this effect and why it was not associated with a decrease in faecal excretion of endogenous Mg remain unknown. Dietary fructose v. glucose did not systematically affect the apparent absorption of Ca and P.

Keywords

FructoseMagnesiumAbsorptionSolubilityRat
Type
Effects of fructose on magnesium absorption and retention
Information
British Journal of Nutrition , Volume 72 , Issue 4 , October 1994 , pp. 567 - 577
Copyright
Copyright © The Nutrition Society 1994

References

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