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Dietary fibre and the pruritus of cholestatic jaundice

Published online by Cambridge University Press:  09 March 2007

M. A. Eastwood ,
S. L. Mowbray ,
R. P. H. Thompson  and
Roger Williams
M. A. Eastwood
Affiliation:
The University Department of Therapeutics, Royal Infirmary, Edinburgh
S. L. Mowbray
Affiliation:
The University Department of Therapeutics, Royal Infirmary, Edinburgh
R. P. H. Thompson
Affiliation:
The Medical Research Council Group on Metabolism and Haemodynamics of Liver Disease, Department of Medicine, and the Department of Chemical Pathology, King's College Hospital, London
Roger Williams
Affiliation:
The Medical Research Council Group on Metabolism and Haemodynamics of Liver Disease, Department of Medicine, and the Department of Chemical Pathology, King's College Hospital, London
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Abstract

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1. In a double reversal experiment, diets containing either a normal or a large amount of lignin fibre were given to four patients with pruritus due to a liver disease.

2. Neither an improvement in symptoms nor a decrease in serum bile acid levels was found. The dose of fibre may have been insufficient, changes in intraluminal pH may have impaired adsorption of bile acids, or, less likely, the concentration of bile acids in the intestine may have been too low.

Type
Research Article
Information
British Journal of Nutrition , Volume 24 , Issue 4 , December 1970 , pp. 1029 - 1032
Copyright
Copyright © The Nutrition Society 1970

References

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