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Dietary fat modifies some metabolic actions of human recombinant tumour necrosis factor α in rats

Published online by Cambridge University Press:  09 March 2007

D. C. Bibby  and
R. F. Grimble
D. C. Bibby
Affiliation:
Department of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO9 3TU
R. F. Grimble
Affiliation:
Department of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO9 3TU
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Abstract

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To examine how fat might influence the metabolic effects of tumour necrosis factor α (TNFα), human recombinant TNFα was given intravenously to rats that had been fed for 12 weeks on diets containing (g/kg) 200 maize oil or 190 coconut oil+10 maize oil. Rectal temperature and tissue composition measurements were made 8 and 24 h after injection. Ambient temperatures of 20° and 25° were employed to accentuate rectal temperature changes. Doses of 30 and 300 μg TNFα/kg body-weight were given, and brought about depression of serum zinc and albumin and elevation of copper. Muscle protein content was decreased and liver protein and Zn content enhanced by TNFα. Serum Zn and liver Zn content were negatively correlated 8 h after injections. Hypothermia developed within 1 h of injection. All responses except the rise in serum Cu and gain in liver Zn were more intense at the higher than at the lower dose of TNFα. Hypothermia was exacerbated by an environmental temperature of 20°. The coconut-oil diet blunted the hypothermia and likewise the changes in serum albumin and Cu content 8 h after injections and in muscle and liver protein after 24 h. Changes in eicosanoid metabolism may be involved in the modulatory effects of the coconut-oil-enriched diet.

Keywords

Tumour necrosis factor αFat and tumour necrosisRat
Type
Nutrition and Responces to cytokines
Information
British Journal of Nutrition , Volume 63 , Issue 3 , May 1990 , pp. 653 - 668
Copyright
Copyright © The Nutrition Society 1990

References

REFERENCES

American Institute of Nutrition (1977). Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
Baracos, V., Rodemann, H. P., Dinarello, C. A. & Goldberg, A. L. (1983). Stimulation of muscle protein degradation and prostaglandin E release by leukocytic pyrogen: a mechanism for the increased degradation of muscle proteins during fever. New England Journal of Medicine 308, 553–558.CrossRefGoogle ScholarPubMed
Beisel, W. T. (1975). Metabolic response to infection. Annual Reviews of Medicine 26, 9–30.CrossRefGoogle ScholarPubMed
Bernheim, H. A., Block, L. H. & Atkins, E. (1979). Fever: pathogenesis, pathophysiology, and purpose. Annals of Internal Medicine 91, 161–270.CrossRefGoogle ScholarPubMed
Bibby, D. C. & Grimble, R. F. (1989 a). Leukotrienes and prostaglandins may be involved in the hypothermic effects of recombinant tumour necrosis factor α in rats. Proceedings of the Nutrition Society 48, 112A.Google Scholar
Bibby, D. & Grimble, R. (1989 b). Temperature and metabolic changes in rats after various doses of tumour necrosis factor α. Journal of Physiology 40, 367–380.CrossRefGoogle Scholar
Bourne, J. M., Bonneil, M., Dumont, O. M., Piciotti, M., Nalbine, G. & Lafton, H. (1988). High dietary fish oil alters the brain polyunsaturated fatty acid composition. Biochimica et Biophysics Acta 960, 458–461.CrossRefGoogle Scholar
Charters, Y. & Grimble, R. (1989). Effect of recombinant human tumour necrosis factor alpha on protein synthesis in liver, skeletal muscle and skin of rats. Biochemical Journal 358, 493–497.CrossRefGoogle Scholar
Cousins, R. J. (1985). Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiological Reviews 65, 238–309.CrossRefGoogle ScholarPubMed
Croft, K. D., Beilin, L. J., Vandongen, R. & Matthews, E. (1984). Dietary modification of fatty acid and prostaglandin synthesis in the rat. Effect of variations in the level of dietary fat. Biochimica et Biophysicn Acta 795, 196–207.CrossRefGoogle ScholarPubMed
Dinarello, C. A. (1987). The biology of interleukin 1 and comparison to tumour necrosis factor. Immunology Letters 16, 227–232.CrossRefGoogle Scholar
Dinarello, C. A., Cannon, J. G., Mier, J. W., Bernheim, H. A., Lopreste, G., Lynn, D. L., Love, R. N., Well, A. C., Auron, P. E., Reuben, R. C., Rich, A., Wolfe, S. M. & Putney, S. D. (1986 a). Multiple biological activities of human recombinant interleukin 1. Journal of Clinical Investigation 11, 1734–1739.CrossRefGoogle Scholar
Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A, Figari, I. S., Palladino, M. A. Jr. & O'Connor, J. V. (1986 b). Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. Journal of Experimental Medicine 163, 1433–1450.CrossRefGoogle ScholarPubMed
DiSilvestro, R. A. & Cousins, R. J. (1984). Mediation of endotoxin-induced changes in zinc metabolism in rats. American Journal of Physiology 247, E436–E441.Google ScholarPubMed
DiSilvestro, R. A. & Cousins, R. J. (1985). Induction of rat metallothionein by interleukin 1. Journal of Leukocyte Biology 31, 697.Google Scholar
Endres, S., Gharbani, R., Kelley, V. E., Kostis, S., Lannemann, G., Jos, W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., Schaefer, E. J., Wolff, S. M. & Dinarello, M. D. (1989). The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin- 1 and tumour necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265–271.CrossRefGoogle ScholarPubMed
Garlick, P. J., McNurlan, M. A. & Preedy, V. R. (1980). A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of lsqb;3H] phenylalanine. Biochemical Journal 192, 719–723.CrossRefGoogle Scholar
Grimble, R. & Bremner, I. (1989). Tumour necrosis factor alpha enhances hepatic metallothionein 1 content but reduces that of the kidney. Proceedings of the Nutrition Society 48, 64A.Google Scholar
Jackson, M. J., Roberts, J. & Edwards, R. H. T. (1988). Effects of dietary-fish-oil feeding on muscle growth and damage in the rat. British Journal of Nutrition 60, 217–224.CrossRefGoogle ScholarPubMed
Jepson, M. M., Bates, P. C. & Millward, D. J. (1986). The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats. Biochemical Journal 235, 329–336.CrossRefGoogle ScholarPubMed
Johnston, P. V. & Marshall, L. A. (1984). Dietary fat, prostaglandins and the immune response. Progress in Food and Nutrition Science 8, 3–25.Google ScholarPubMed
Kauffman, C. A., Jones, P. G. & Kluger, M. J. (1986). Fever and malnutrition: endogenous pyrogen/interleukin-1 in malnourished patients. American Journal of Clinical Nutrition 44, 449–452.CrossRefGoogle ScholarPubMed
Keenan, R. A., Moldawer, L. L., Yang, R. D., Kawamura, I., Blackburn, G. L. & Bistrian, B. R. (1982). An altered response by peripheral leukocytes to synthesize or release leukocyte endogenous mediator in critically ill, protein-malnourished patients. Journal of Laboratory and Clinical Medicine 100, 844–857.Google ScholarPubMed
Kettelhut, I. C., Fiers, W. & Goldberg, A. L. (1987). The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors. Proceedings of the National Academy of Sciences, USA 84, 4273–4277.CrossRefGoogle ScholarPubMed
Lowry, O. H., Rosebrough, N. H., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 219, 151–159.Google Scholar
McPherson, J. B. & Everard, B. W. (1972). Serum albumin estimation: modification of the bromocresol green method. Clinica Chimica Acta 37, 117–119.CrossRefGoogle Scholar
Magrum, L. J. & Johnston, P. V. (1985). Effect of culture in vitro with eicosatetraenoic (20:4 (n−6)) and eicosapentanoic (29: 5 (n−3)) acids on fatty acid composition, prostaglandin synthesis and chemiluminescence of rat peritoneal macrophages. Biochimica et Biophysica Acta 836, 354–360.CrossRefGoogle Scholar
Moncada, S. & Vane, J. R. (1983). Essential fatty acids and their prostanoid derivatives. British Medical Bulletin 39, 209–295.CrossRefGoogle Scholar
Perlmutter, D. H., Dinarello, C. A., Punsal, P. I. & Colten, H. R. (1986). Cachectin/tumor necrosis factor regulated hepatic acute-phase gene expression. Journal of Clinical Investigation 78, 1349–1354.CrossRefGoogle ScholarPubMed
Poole, S., Gordon, A. H., Baltz, M. & Stenning, B. E. (1984). Effect of bacterial endotoxin in body temperature, plasma zinc and plasma concentration of the acute-phase protein serum amyloid P component in mice. British Journal of Experimental Pathology 65, 431–439.Google ScholarPubMed
Revhaug, A, Michie, R, Manson, J. M., Waters, J. M., Dinarello, C. A., Wolff, S. M. & Wilmore, D. W. (1988). Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans. Archives of Surgery 13, 162–10.CrossRefGoogle Scholar
Sobrado, J., Moldawer, L. L., Bistrain, B. R., DinarelloC. A, C. A,& Blackburn, G. I. (1983). Effect of Abunrofen on fever and metabolic changes induced by continuous infusion of leukocyte pyrogen (interleukin 1) or endotoxin. Infection and Immunity 42, 997–1005.CrossRefGoogle ScholarPubMed
Szekely, M. & Szelenyi, Z. (1979). Endotoxin fever in the rat. Acta Physiological Academiae Scientiarum Hungaricae 53, 265–277.Google ScholarPubMed
Tocco-Bradley, R. & Kluger, M. J. (1984). Zinc concentration and survival in rats infected with Salmonella typhimurium. Infection and Immunity 45, 332–338.CrossRefGoogle ScholarPubMed
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J. II, Zentalla, A, Albert, J. D., Shires, G. T. & Cerami, A. (1986). Shock and tissue injury induced by recombinant human cachectin. Science 234, 47–74.CrossRefGoogle ScholarPubMed
Wan, J. & Grimble, R. F. (1986 a). Inhibitory effects of indomethacin on some features of the metabolic response to Escherichia coli endotoxin in rats. Proceedings of the Nutrition Society 45, 51.Google Scholar
Wan, J. & Grimble, R. F. (1986 b). Effect of a lipoxygenase inhibitor, AA861, on the metabolic response to Escherichia coli endotoxin in rats. Proceedings of the Nutrition Society 45, 38.Google Scholar
Wan, J. & Grimble, R. F. (1987). Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin. Clinical Science 72, 383–385.CrossRefGoogle ScholarPubMed