Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-24T01:53:10.011Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary cholesterol lowers the activity of butyrylcholinesterase (EC 3.1.1.8), but elevates that of esterase-1 (EC 3.1.1.1) in plasma of rats

Published online by Cambridge University Press:  02 April 2007

H. A. Van Lith  and
A. C. Beynen
H. A. Van Lith
Affiliation:
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD Utrecht, The Netherlands
A. C. Beynen
Affiliation:
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD Utrecht, The Netherlands
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The question addressed is whether an increased intake of cholesterol affects esterase-1 (EC 3.1.1.1; ES-1) and butyrylcholinesterase (EC 3.1.1.8) activity in plasma. Rats were fed on a purified diet either without or with cholesterol (10 g/kg) added at the expense of the carbohydrate source. Dietary cholesterol significantly decreased plasma butyrylcholinesterase activity, but raised plasma ES-1 activity. Evidence is discussed, suggesting that plasma butyrylcholinesterase is involved in plasma cholesterol metabolism, whereas esterase-1 is involved in intestinal cholesterol absorption.

Keywords

ButyrylcholinesteraseEsterase-1 (ES- 1)Dietary cholesterolPlasmaLiverRat
Type
Lipid Metabolism
Information
British Journal of Nutrition , Volume 70 , Issue 3 , November 1993 , pp. 721 - 726
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Abell, L. L., Levy, B. B., Brodie, B. B. & Kendall, F. E. (1952). A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. Journal of Biological Chemistry 195, 357–366.CrossRefGoogle Scholar
Augustinsson, K. B. (1958). Electrophoretic separation and classification of blood plasma esterases. Nature 181, 1786–1789.CrossRefGoogle ScholarPubMed
Beynen, A. C. (1989). Increased concentrations of liver cholesterol in rats fed lactulose. Die Nahrung 33, 89–90.CrossRefGoogle ScholarPubMed
Beynen, A. C., Fielmich-Bouman, A. M. & Lemmens, A. G. (1988 a). Dietary lactitol elevates liver cholesterol in rats. International Journal for Vitamin and Nutrition Research 58, 471–472.Google ScholarPubMed
Beynen, A. C., Lemmens, A. G., De Bruijne, J. J., Ronai, A., Wassmer, B., Von Deimling, O., Katan, M. B. & Van Zutphen, L. F. M. (1987). Esterases in inbred strains of mice with differential cholesterolemic responses to a high-cholesterol diet. Atherosclerosis 63, 239–249.CrossRefGoogle ScholarPubMed
Beynen, A. C., Lemmens, A. G., De Vries, H. & Van Der Meer, R. (1988 b). Differential metabolic basis for the hypocholesterolemic effects of cholestyramine and pectin in rats. Atherosclerosis 73, 87–88.CrossRefGoogle ScholarPubMed
Ellman, G. L., Courtney, K. D., Andres, V. & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology 7, 88–95.CrossRefGoogle ScholarPubMed
Grooten, H. N. A., Ritskes-Hoitinga, J., Mathot, J. N. J. J., Lemmens, A. G. & Beynen, A. C. (1991). Dietary fluoride prevents phosphorus-induced nephrocalcinosis. Biological Trace Element Research 29, 147–155.CrossRefGoogle ScholarPubMed
Herman, S., Sediaoetama, A. D., Karayadi, D. & Beynen, A. C. (1991). Influence of background composition of the diet on the lipemic effect of fish oil versus corn oil in rats. Journal of Nutrition 121, 622–630.CrossRefGoogle Scholar
Kutty, K. M. (1980). Biological function of cholinesterase. Clinical Biochemistry 13, 239–243.CrossRefGoogle ScholarPubMed
Osada, J., Hortensia, A., Gonzalo, C., Miro-Obradors, M. J. & Palacios-Alaiz, E. (1989). Changes in serum cholinesterase (EC 3.1. 1.8) activity in rats consuming a high-fat diet. British Journal of Nutrition 62, 343–348.CrossRefGoogle ScholarPubMed
Siedel, J., Hagelle, E. O., Ziegenhorn, J. & Wahlefeld, A. W. (1983). Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clinical Chemistry 29, 1075–1080.CrossRefGoogle ScholarPubMed
SPSS/PC (1988). Statistical Package for the Social Sciences: Base Manual V 2.0. Chicago, IL: SPSS Inc.Google Scholar
Van Lith, H. A., Haller, M., Van Hoof, I. J. M.. Van Der Wouw, M. J. A., Van Zutphen, L. F. M. & Beynen, A. C. (1993). Characterization of rat plasma esterase ES-I A concerning its molecular and catalytic properties. Archives of Biochemistry and Biophysics 301, 265–274.CrossRefGoogle Scholar
Van Lith, H. A., Haller, M., Van Tintelen, G., Van Zutphen, L. F. M. & Beynen, A. C. (1992 a). Plasma esterase-1 (ES-1) activity in rats is influenced by the amount and type of dietary fat and butyrylcholinesterase activity by the type of dietary fat. Journal of Nutrition 122, 2109–2120.CrossRefGoogle ScholarPubMed
Van Lith, H. A., Haller, M., Van Zutphen, L. F. M. & Beynen, A. C. (1991 a). Determination of rat-plasma esterase- 1 (ES- 1) activity by scanning densitometry of gradient polyacrylamide gels with zymogram detection. Electrophoresis 12, 1045–1050.CrossRefGoogle ScholarPubMed
Van Lith, H. A., Herman, S., Zhang, X., Van Der Palen, J. J. G., Van Zutphen, L. F. M. & Beynen, A. C. (1990). Influence of dietary fats on butyrylcholinesterase and esterase-l (ES-1) activity in plasma of rats. Lipids 25, 779–786.CrossRefGoogle ScholarPubMed
Van Lith, H. A., Meijer, G. W., Van Der Wouw, M. M. J., Den Bieman, M., Van Tintelen, G., Van Zutphen, L. F. M. & Beynen, A. C. (1992 b). Influence of amount of dietary fat and protein on esterase-l (ES-1) activities of plasma and small intestine in rats. British Journal of Nutrition 67, 379–390.CrossRefGoogle ScholarPubMed
Van Lith, H. A., Van Zutphen, L. F. M. & Beynen, A. C. (1991 b). Butyrylcholinesterase activity in plasma of rats and rabbits fed high-fat diets. Comparative Biochemistry and Physiology 98A, 339–342.CrossRefGoogle Scholar
Van Zutphen, L. F. M. & Den Bieman, M. G. C. W. (1988). Gene mapping and linkage homology. In New Developments in Biosciences: Their Implications for Laboratory Animal Science. pp. 197–201 [Beynen, A. C. and Solleveld, H. A., editors]. Dordrecht, The Netherlands: Martinus Nijhoff Publishers.CrossRefGoogle Scholar
Zhang, X., Joles, J. A., Koomans, H. A., Van Tol, A. & Beynen, A. C. (1992). Excessivecholesterolemic response in analbuminemic rats fed a cholesterol-rich diet containing casein. Journal of Nutrition 122, 520–527.CrossRefGoogle ScholarPubMed