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Dietary ascorbic acid and muscle carnitine (β-OH-γ-(trimethylamino) butyric acid) in guinea-pigs

Published online by Cambridge University Press:  25 February 2008

R. E. Hughes ,
R. J. Hurley  and
Eleri Jones
R. E. Hughes
Affiliation:
University of Wales Institute of Science and Technology, Cardiff, Wales
R. J. Hurley
Affiliation:
University of Wales Institute of Science and Technology, Cardiff, Wales
Eleri Jones
Affiliation:
University of Wales Institute of Science and Technology, Cardiff, Wales
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Abstract

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Tissue ascorbic acid (AA) contents of approximately 12 and 100% saturation respectively were produced in two groups of guinea-pigs. The ‘low-AA’ group had significantly lower muscle carnitine concentrations than the ‘high-AA’group. There was no concomitant emergence of the symptoms customarily regarded as characteristic of hypovitaminosis C. It is concluded that muscle carnitine (β-OH-γ-(trimethylamino) butyric acid) is a highly-sensitive indicator of tissue AA contents; this could account for the lassitude and fatigue reported to precede the emergence of frank scurvy in man.

Type
Short Papers
Information
British Journal of Nutrition , Volume 43 , Issue 2 , March 1980 , pp. 385 - 387
Copyright
Copyright © The Nutrition Society 1980

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