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Diet and cancer: assessing the risk

Published online by Cambridge University Press:  09 March 2007

C. I. R. Gill  and
I. R. Rowland
C. I. R. Gill*
Affiliation:
University of Ulster, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK
I. R. Rowland
Affiliation:
University of Ulster, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK
*
*Corresponding author: Dr C. I. R. Gill, fax +44 (0) 2870 324965, [email protected]
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Abstract

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Globally, colorectal cancer (CRC) is a leading cause of mortality from malignant disease. Case–control and cohort studies provide strong support for a role of diet in the aetiology of CRC. However to establish causal relationships and to identify more precisely the dietary components involved, intervention studies in human subjects are required. Cancer is an impractical endpoint in terms of numbers, cost, study duration and ethical considerations. Consequently, intermediate biomarkers of the disease are required. This review aims to provide an overview of the intermediate endpoints available for the study of CRC, particularly non-invasive faecal biomarkers. Examples of their use in dietary intervention studies are given.

Keywords

Colorectal cancerBiomarkersDietGut microflora
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue S1 , September 2002 , pp. s73 - s87
Copyright
Copyright © The Nutrition Society 2002

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