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The development of cold-induced thermogenesis and the structure of brown adipocyte mitochondria in genetically-obese (ob/ob) mice

Published online by Cambridge University Press:  09 March 2007

D. Hull  and
J. Vinter
D. Hull
Affiliation:
Department of Child Health, E Floor, East Block, University Hospital, Nottingham NG7 2UH
J. Vinter
Affiliation:
Department of Child Health, E Floor, East Block, University Hospital, Nottingham NG7 2UH
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Abstract

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1. The onset of cold-induced thermogenesis was studied in a strain of mice which produced among their offspring genetically-obese (ob/ob) individuals. A thermogenic response was present in a majority by day 5 after birth.

2. The thermogenic response to cold was measured on days 5, 10 or 15 after birth, and the animals reared and the onset of obesity noted. The correlation between the subsequent development of obesity and a poor thermogenic response in early life was low.

3. A poor thermogenic response at day 15 was associated with the presence in brown adipocytes of mitochondria with disordered internal structures.

4. At day 42 both non-obese and obviously-obese mice showed a similar thermogenic response to moderate cold exposure.

5. It would seem that in this strain of mice disordered internal mitochondria1 structure in brown adipose tissue is associated with a poor thermogenic response to cold, but not invariably with the subsequent onset of obesity.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 1 , July 1984 , pp. 33 - 39
Copyright
Copyright © The Nutrition Society 1984

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