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A critical evaluation of the application of biomarkers in epidemiological studies on diet and health

Published online by Cambridge University Press:  09 March 2007

C. P. Wild*
Affiliation:
Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research School of Medicine, University of Leeds, UK
C. Andersson
Affiliation:
National Food Administration, Box 622, S-751 26 Uppsala, Sweden
N. M. O'Brien
Affiliation:
Department of Food Science and Technology, University College, Cork, Ireland
L. Wilson
Affiliation:
Central Science Laboratory, Sand Hutton, York, UK
J. A. Woods
Affiliation:
Department of Food Science and Technology, University College, Cork, Ireland
*
*Corresponding author: Dr C. P. Wild, fax +44(0) 113 233 6603, email [email protected]
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Abstract

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Type
Research Article
Copyright
Copyright © The Nutrition Society 2001

References

Adlercreutz, H (1993) Dietary lignans and isoflavonoid phytoestrogens, and cancer. Clinical Laboratory 2a, 412.Google Scholar
Adlercreutz, H (1995) Phytoestrogens: epidemiology and a possible role in cancer protection. Environmental Health Perspectives 103(Suppl 7); 103112.Google Scholar
Adlercreutz, H, Fotsis, T, Bannwart, C, Wäjälä, K, Mäkelä, T, Brunow, G & Hase, T (1986) Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitural diets. Journal of Steroid Biochemistry 25, 791797.CrossRefGoogle Scholar
Adlercreutz, H, Fotsis, T, Heikkine, R, Dwyer, JT, Woods, M, Goldin, BR & Gorbach, SL (1982) Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet ii, 12951299.CrossRefGoogle Scholar
Adlercreutz, H, Fotsis, T, Lampe, J, Wähälä, K, Mäkelä, T, Brunow, G & Hase, T (1993) Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas-chromatography mass-spectrometry. Scandinavian Journal of Clinical Laboratory Investigation 215, 518.CrossRefGoogle ScholarPubMed
Adlercreutz, CHT, Goldin, BR, Gorbach, SL, Höckerstedt, KAV, Watanabe, S, Hämäläinen, EK, Markkanen, MH, Mäkelä, TH, Wähälä, KT, Hase, TA & Fotsis, T (1995) Soybean phytoestrogen intake and cancer risk. Journal of Nutrition 125, 757S770S.Google Scholar
Adlercreutz, H, Hanjo, H, Higashi, A, Fotsis, T, Hämäläinen, E, Hasegawa, T & Okada, H (1991) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming traditional Japanese diet. American Journal of Clinical Nutrition 54, 10931100.Google Scholar
Bailey, LB & Gregory, JF (1999a) Folate metabolism and requirements. Journal of Nutrition 129, 779782.CrossRefGoogle ScholarPubMed
Bailey, LB & Gregory, JF III (1999b) Polymorphisms of methylenetetrahydrofolate reductase and other enzymes, metabolic significance, risks and impact on folate requirement. Journal of Nutrition 129, 919922.Google Scholar
Baird, DD, Umbach, DM, Lansdell, L, Hughes, CL, Setchell, KDR, Weinberg, CR, Haney, AF, Wilcox, AJ & McLachlan, JA (1995) Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. Journal of Clinical and Endocrine Metabolism 80, 16851690.Google ScholarPubMed
Barnes, S (1999) Phytoestrogens and breast cancer. Baillière’s Clinical Endocrinology and Metabolism 12, 559579.CrossRefGoogle Scholar
Basu, TK & Dickerson, JW (1996) Vitamins in Human Health and Disease. Wallingford: CAB International.Google Scholar
Beecher, GR & Khachik, F (1992) Qualitative relationship of dietary and plasma carotenoids in human beings. Annals of the New York Academy of Sciences 669, 320321.Google Scholar
Bennett, MJ, Tershakovec, AM, Cortner, JA & Shannon, BM (1993) A quality assurance program for the measurement of capillary blood cholesterol levels in private paediatric practices The Children’s Health Project. American Journal of Diseases in Children 147(3), 340345.CrossRefGoogle ScholarPubMed
Bourdoux, PP (1993) Biochemical evaluation of iodine status. In Iodine Deficiency in Europe. A Continuing Concern, pp.119125. [Delange, F, Dunn, JT & Glinoer, D, editors]. New York: Plenum Press.Google Scholar
Braun, MM, Helzlsouer, KJ, Hollis, BW & Comstock, GW (1995) Prostate cancer and prediagnostic levels of serum vitamin D metabolites (Maryland, United States). Cancer Causes and Control 6, 235239.CrossRefGoogle ScholarPubMed
Brouwer, IA, van Dusseldorp, M, Thomas, CMG, Duran, M, Hautvast, JGAJ, Eskes, TKAB & Steefers-Theunissen, RPM (1999a) Low-dose folic acid supplementation decreases plasma homocysteine concentrations, a randomized trial. American Journal of Clinical Nutrition 69, 99104.CrossRefGoogle ScholarPubMed
Brouwer, IA, van Dusseldorp, M, West, CE, Meyboom, S, Thomas, CMG, Duran, M, van het Hof, K, Eskes, TKAB, Hautvast, JGAJ & Steefers-Theunissen, RPM (1999b) Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. Journal of Nutrition 129, 11351139.Google Scholar
Brug, J, Lowik, MR, Wedel, M & Odink, J (1992) Iodide excretion before and after revision of goiter prophylaxis (Dutch nutrition surveillance system). European Journal of Clinical Nutrition 46, 671678.Google Scholar
Byrne, C, Sinha, R, Platz, EA, Giovannucci, E, Colditz, GA, Hunter, DJ, Speizer, FE & Willett, WC (1998) Predictors of dietary heterocyclic amine intake in three prospective cohorts. Cancer, Epidemiology Biomarkers and Prevention 7, 523530.Google ScholarPubMed
Cassidy, A, Bingham, S & Setchell, KDR (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. American Journal of Clinical Nutrition 60, 333340.Google Scholar
Chen, Z, Zheng, W, Custer, LJ, Dai, Q, Shu, X-O, Jin, F & Franke, AA (1999) Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai. Nutrition and Cancer 33, 8287.CrossRefGoogle ScholarPubMed
Clugston, GA, Hetze, BS, (1994) Iodine. In Modern Nutrition in Health and Disease, 8th edn 1, pp. 252263.[Shils, ME, Olson, JA and Shike, M editiors]. Malver, PA: Lea and Febiger.Google Scholar
Cocker, J, Nutley, BP & Wilson, HK (1996) Methylene bis (2-chloroaniline) (MbOCA), towards a biological monitoring guidance value. Biomarkers 1, 185189.CrossRefGoogle ScholarPubMed
Corder, EH, Friedman, GD, Vogelman, JH & Orentreich, N (1995) Seasonal variation in vitamin D, vitamin D-binding protein and dehydroepiandrosterone. Risk of prostate cancer in black and white men. Cancer, Epidemiology Biomarkers and Prevention 4, 655659.Google ScholarPubMed
Corder, EH, Guess, HA, Hulka, BS, Friedman, GD, Sadler, M, Vollmer, RT, Lobaugh, B, Drezner, MK, Vogelman, JH & Orentreich, N (1993) Vitamin D and prostate cancer, a prediagnostic study with stored sera. Cancer, Epidemiology Biomarkers and Prevention 2, 467472.Google Scholar
Cunnane, SC, Hamadeh, MJ, Liede, AC, Thompson, LU, Wolever, TMS & Jenkins, DJA (1995) Nutritional attributes of traditional flaxseed in healthy young adults. American Journal of Clinical Nutrition 61, 6268.Google Scholar
Czeizel, AE (1995) Folic acid in the prevention of neural tube defects. Journal of Pediatric Gastroenterology and Nutrition 2, 416.Google Scholar
de Bree, A, van Dusseldorp, M, Brouwer, IA, van het Hof, KH & Steegers-Theunissen, RPM (1997) Folate intake in Europe, recommended, actual and desired intake. European Journal of Clinical Nutrition 51, 643660.Google Scholar
De Plaen, P, Claeys-Thoreau, F & De Boeck, R (1996) External quality assessment scheme in Belgium. Heavy metal analyses. Annals of the Institute Super Sanita 32(2), 215220.Google Scholar
Duff, EM & Cooper, ES (1994) Neural tube defects in Jamaica following Hurricane Gilbert. American Journal of Public Health 84, 473476.Google Scholar
Dunn, JT (1993) Techniques for measuring urinary iodine – an update http://www.mn-net.org/index.cfm?fuseaction=showArticle&article_id=72.Date:010601.10p.Google Scholar
Evans, RW, Sankey, SS, Hauth, BA, Sutton-Tyrrell, K, Kamboh, MI & Kuller, LH (1996) Effect of sample storage on quantitation of lipoprotein(a) by an enzyme-linked immunosorbent assay. Lipids 31(11), 11971203.CrossRefGoogle Scholar
Fleming, A & Copp, AJ (1998) Embryonic folate metabolism and mouse neural tube defects. Science 280, 21072109.Google Scholar
Franke, AA & Custer, LJ (1994) High-performance liquid chromatographic assay of isoflavonoids and coumestrol from human urine. Journal of Chromatography B 662, 4760.Google Scholar
Frerichs, RR, Silarug, N, Eskes, N, Pagcharoenpol, P, Rodklai, A, Thangsupachai, S & Wongba, C (1994) Saliva-based HIV-antibody testing in Thailand. AIDS 8(7), 885894.CrossRefGoogle Scholar
Friesen, MD, Kaderlik, K, Lin, D, Garren, L, Bartsch, H, Lang, NP & Kadlubar, FF (1994) Analysis of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human tissues by alkaline hydrolysis and gas chromatography/electron capture mass spectroscopy, validation by comparison with 32P-postlabelling. Chemical Research in Toxicology 7(6), 733739.CrossRefGoogle Scholar
Ganguly, S, Taioli, E, Baranski, B, Cohen, B, Toniolo, P & Garte, SJ (1996) Human metallothionein gene expression determined by quantitative reverse transcription-polymerase chain reaction as a biomarker of cadmium exposure. Cancer Epidemiology Biomarkers and Prevention 5(4), 297301.Google Scholar
Gann, PH, Ma, J, Hennekens, CH, Hollis, BW, Haddad, JG & Stampfer, MJ (1996) Circulating vitamin D metabolites in relation to subsequent development of prostate cancer. Cancer Epidemiology Biomarkers and Prevention 5, 121126.Google Scholar
Gerhardsson de Verdier, M, Hagman, U, Peters, RK, Steineck, G & Overvik, E (1991) Meat, cooking methods and colorectal cancer, a case referent study in Stockholm. International Journal of Cancer 49, 16.Google ScholarPubMed
Gibson, RS (1990) Principles of Nutritional Assessment. New York: Oxford University Press.Google Scholar
Gompertz, D (1997) Quality control of biomarker measurements in epidemiology. IARC Scientific Publications 142, 215222.Google Scholar
Greenblatt, MS, Bennett, WP, Hollstein, M & Harris, CC (1994) Mutations in the p53 tumor suppressor gene, clues to cancer etiology and molecular pathogenesis [review]. Cancer Research 54, 48554878.Google ScholarPubMed
Gunter, EW, Bowman, BA, Caudill, SP, Twite, DB, Adam, MJ & Sampson, EJ (1996) Results of an international round robin for serum and whole-blood folate. Clinical Chemistry 42, 16891694.CrossRefGoogle ScholarPubMed
Hanchette, CL & Schwartz, GG (1992) Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer 70, 28612869.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Herbert, VD & Colman, N (1988)Folic acid and vitamin B12. In Modern Nutrition in Health and Disease, Chap21, pp. 388413[shils, ME and Young, VR, editors] Philadelpaia, PA: Lea and Febiger.Google Scholar
Herman, C, Adlercreutz, H, Goldin, BR, Gorbach, SL, Höckerstedt, KAV, Watanabe, S, Hämäläinen, EK, Markkanen, MH, Mäkelä, TH, Wäjälä, KT, Hase, TA & Fotsis, T (1995) Soybean phytoestrogen intake and cancer risk. Journal of Nutrition 125, 757S770S.Google Scholar
Hetzel, BS & Dunn, JT (1989) The iodine deficiency disorders, their nature and prevention. Annual Reviews of Nutrition 9, 2138.Google Scholar
Holick, MF (1990) The use and interpretation of assays for vitamin D and its metabolites. Journal of Nutrition 120, 14641469.CrossRefGoogle ScholarPubMed
Horn-Ross, PL, Barnes, S, Kirk, M, Coward, L, Parsonnet, J & Hiatt, RA (1997) Urinary phytoestrogen levels in young women from a multiethnic population. Cancer Epidemiology Biomarkers and Prevention 6, 339345.Google Scholar
Humfrey, CDN (1998) Phytoestrogens and human health effects, weighing up the current evidence. Natural Toxins 6, 5160.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
Hurrell, RF (1997) Bioavailability of iodine. European Journal of Clinical Nutrition 51(Suppl 1), S9S12.Google Scholar
Hussain, SP & Harris, CC (1998) Molecular epidemiology of human cancer, contribution of mutation spectra studies of tumour suppressor genes. Cancer Research 58, 40234037.Google Scholar
Hutchins, AM, Slavin, JL & Lampe, JW (1995) Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products.. Journal of the American Dietetic Association 95, 545551.CrossRefGoogle ScholarPubMed
IARC (1992) Cancer Incidence in Five Continents IARC Scientific Publications. no120, Lyon: IARC.Google Scholar
IARC (1994) IARC Scientific Publication. no 56, Lyon: IARC.Google Scholar
Ingles, SA, Ross, RK, Yu, MC, Irvine, RA, La Pera, G, Haile, RW & Coetzee, GA (1997) Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. Journal National Cancer Institute 89, 166170.Google ScholarPubMed
Ingram, D (1998) Phyto-oestrogens and breast cancer. Authors reply. Lancet 351, 138139.CrossRefGoogle Scholar
Jacob, RA, Wu, M-M, Henning, SM & Swendseid, ME (1994) Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction Journal of Nutrition 124, 10721080.CrossRefGoogle ScholarPubMed
Kaaks, R, Riboli, E & Sinha, R (1997) Biochemical markers of dietary intake. IARC Scientific Publications 142, pp. 103126. Lyon: IARC.Google Scholar
Kakiuchi, H, Watanabe, M, Ushijima, T, Toyota, M, Imai, K, Weisburger, JH, Sugimura, T & Nagao, M (1995) Specific 5′-GGGA-3′→5′-GGA-3′ mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Proceedings of the National Academy of Sciences USA 92, 910914.CrossRefGoogle ScholarPubMed
Karr, SC, Lampe, JW, Hutchins, AM & Slavin, JL (1997) Urinary isoflavonoid excretion in humans is dose dependent at low to moderate levels of soy-protein consumption. American Journal of Clinical Nutrition 66, 4651.CrossRefGoogle ScholarPubMed
Key, T, Oakes, S, Davey, G, Moore, J, Edmond, LM, McLoone, UJ & Thurnham, DI (1996) Stability of vitamins A, C and E, carotenoids, lipids and testosterone in whole blood stored at 4°C and 24 hours before separation of serum and plasma. Cancer Epidemiology Biomarkers and Prevention 5(10), 811814.Google Scholar
King, RA & Bursill, DB (1998) Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. American Journal of Clinical Nutrition 67, 867872.Google Scholar
Kirke, PN, Mollowy, AM, Daly, LE, Burke, H, Weir, DG & Scott, JM (1993) Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Quarterly Journal of Medicine 86, 703708.Google Scholar
Kirkman, LNM, Lampe, JW, Campbell, DR, Martini, MC & Slavin, JL (1995) Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutrition and Cancer 24, 112.CrossRefGoogle ScholarPubMed
Knize, MG, Dolbeare, FA, Carroll, KL & Felton, JS (1994) Effects of cooking time and temperature on the heterocyclic amine content of fried-beef patties. Food Chemistry and Toxicology 32, 595603.Google Scholar
Kohlmeier, L (1995) Future of dietary exposure assessment. American Journal of Clinical Nutrition 61(suppl), 702S709S.CrossRefGoogle ScholarPubMed
Kohlmeier, L, Kark, J, Gomez-Gracia, E, Martin, B, Steck, S, Kardinaal, A, Ringstead, J, Thamm, M, Masaeu, V, Riemersma, R, Martin-Moreno, J, Huttunen, J & Kok, F (1997) Lycopene and myocardial infarction risk in the EURAMIC study. American Journal of Epidemiology 146(8), 618626.Google Scholar
Kopp, P (1998) Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the French paradox?. European Journal of Endocrinology 138, 619620.CrossRefGoogle Scholar
Krumdieck, CL, Fukushima, K, Fukushima, T, Shiota, T & Butterworth, CE Jr (1978) A long-term study of the excretion of folate and pterins in a human subject after ingestion of 14C folic acid, with observations on the effect of diphenylhydantoin administration.. American Journal of Clinical Nutrition 31, 8893.CrossRefGoogle Scholar
Kuiper, GGJM, Enmark, E, Peltohuikki, MN, Bilsson, S & Gustafsson, JA (1996) Cloning a novel estrogen receptor expressed in rat prostate and ovary. Proceedings of the National Academy of Sciences USA 93, 59255930.CrossRefGoogle ScholarPubMed
Lamberg, BA (1993) Review. Iodine deficiency disorders and endomic goitre. European Journal of Clinical Nutrition 47, 18.Google Scholar
Lampe, JW, Martini, MC, Kurze, MS, Adlercreutz, H & Slavin, JL (1994) Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. American Journal of Clinical Nutrition 60, 122128.Google Scholar
Landi, MT & Caporaso, N (1997) Sample collection, processing and storage. IARC Scientific Publication no. 142, pp. 223236. Lyon: IARC.Google ScholarPubMed
Lang, NP, Butler, MA, Massengill, J, Lawson, M, Stotts, RC, Hauer Jense, M & Kadlubar, FF (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiology Biomarkers and Prevention 3, 675682.Google ScholarPubMed
Larsen, WJ (1993) Human Embryology. New York, Churchill Livingstone p. 479.Google Scholar
Layton, DW, Bogen, KT, Knize, MG, Hatch, FT, Johnson, VM & Felton, JS (1995) Cancer risk of heterocyclic amines in cooked foods, an analysis and implications for research. Carcinogenesis 16, 3952.Google Scholar
Locksmith, GJ & Duff, P (1998) Preventing neural tube defects, the importance of periconceptional folic acid supplements. Obstetrics and Gynecology 91, 10271034.Google Scholar
Lu, L-JW & Anderson, KE (1998) Sex and long-term soy diets affect the metabolism and excretion of soy isoflavones in humans. American Journal of Clinical Nutrition 68, 1500S1504S.CrossRefGoogle Scholar
Lu, L-JW, Grady, JJ, Marshall, MV, Ramanujam, VMS & Anderson, KE (1995) Altered time course of urinary daidzein and genistein excretion during chronic soya diet in healthy male subjects. Nutrition and Cancer 24, 311323.Google Scholar
Lu, L-JW, Lin, S-N, Grady, JJ, Marshall, MV, Nagamani, M & Anderson, KE (1996) Altered kinetics and extent of urinary daidzein and genistein excretion in women during chronic soya exposure. Nutrition and Cancer 26, 289302.Google Scholar
Lynch, AM, Knize, MG, Bobbis, AR, Gooderham, NJ, Davies, DS & Murray, S (1992) Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef. Cancer Research 52, 62166223.Google Scholar
Ma, J, Stampfer, MJ, Gann, PH, Hough, HL, Giovannucci, E, Kelsey, KT, Hennekins, CH & Hunter, DJ (1998) Vitamin D receptor polymorphisms, circulating vitamin D metabolites and risk of prostate cancer in United States physicians. Cancer Epidemiology Biomarkers and Prevention 7, 385390.Google ScholarPubMed
Mäkelä, S, Strauss, L, Saarinen, N, Ahotupa, M & Santti, R (1998) Biological effects of phytoestrogens. In COST 916 Workshop ‘Phyto-oestrogens, Exposure, Bioavailability, Health Benefits and Safety Concerns’, pp. 26–27, Doorwerth, The Netherlands.Google Scholar
Mazur, W (1999) Phytoestrogen content in foods. Baillière’s Clinical Endocrine Metabolism 12, 729742.CrossRefGoogle Scholar
Michaud, DS, Giovannucci, EL, Ascherio, A, Rimm, EB, Forman, MR, Sampson, L & Willett, WC (1998) Associations of plasma carotenoid concentrations and dietary intake of specific carotenoids in samples of two prospective cohort studies using a new carotenoid database. Cancer Epidemiology Biomarkers and Prevention 7, 283290.Google ScholarPubMed
Mills, JL, McPartlin, JM, Kirke, PN, Lee, YJ, Conley, MR & Weir, DG (1995) Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 345, 149151.CrossRefGoogle ScholarPubMed
Mills, JL, Scott, JM, Kirke, PN, McPartlin, JM, Conley, MR, Weir, DG, Molloy, AM & Lee, YJ (1996) Homocysteine and neural tube defects. Journal of Nutrition 126, 756s760s.Google Scholar
Mitchell, JH & Collins, AR (1998) Effects of a soya milk supplement on oxidative DNA damage in men a pilot study. In COST 916 Workshop ‘Phyto-oestrogens, Exposure, Bioavailability, Health Benefits and Safety Concerns’ p. 28, Doorwerth, The Netherlands.Google Scholar
Møller, A (1996) Levnedsmiddeltabeller, 4th edn, pp. 1717. Levnedsmiddelstyrelsen, Søborg.Google Scholar
Morton, M, Matos-Ferreira, A & Abranches-Monteiro, L (1997) Measurement and metabolism of isoflavonoids and lignans in the human male. Cancer Letters 114, 145151.Google Scholar
MRC Vitamin Study Research Group (1991) Prevention of neural tube defects. Results of the Medical Research Council vitamin study. Lancet 338, 131137.Google Scholar
Nesbitt, P, Lam, Y & Thompson, L (1999) Human metabolism of mammalian lignan precursors in raw and processed flaxseed. American Journal of Clinical Nutrition 69, 549555.Google Scholar
O’Keefe, CA, Bailey, LB, Thomas, EA, Hofler, SA, Davis, BA, Cerda, JJ & Gregory, JF (1995) Controlled dietary folate affects folate status in nonpregnant women. Journal of Nutrition 125, 27172725.Google ScholarPubMed
Parker, SL, Tong, T, Bolden, S & Wingo, PA (1996) Cancer statistics 1996. CA Cancer Journal for Clinicians 46, 526.Google Scholar
Perera, FP (1996) Molecular epidemiology, insights into cancer susceptibility, risk assessment and prevention (review). Journal of the National Cancer Institute 88, 496509.CrossRefGoogle Scholar
Pero, R, Olsson, A, Berglund, G, Janzon, L, Larsson, SA & Elmstahl, S (1993) The Malmo biological bank. Journal of International Medicine 233, 6367.Google Scholar
Pero, RW, Olsson, A, Bryngelsson, C, von Schantz, T, Carlsson, S, Janzon, L, Berglund, G & Elmstahl, S (1998a) Quality control program for storage of biologically banked blood specimens in the Malmo diet and cancer study. Cancer Epidemiology Biomarkers and Prevention 7, 803808.Google Scholar
Pero, RW, Olsson, A, Bryngelsson, C, von Schantz, T, Simanaitis, M, Sternb, NH, Larsson, SA, Elmstahl, S, Janzon, L & Berglund, G (1998b) Feasibility and quality of biological banking of human normal and tumour tissue specimens as sources of DNA for the malmo diet and cancer study. Cancer Epidemiology Biomarkers and Prevention 7, 809812.Google Scholar
Price, KR & Fenwick, GR (1985) Naturally occurring oestrogens in foods – a review. Food Additives and Contaminants 2, 73106.CrossRefGoogle ScholarPubMed
Rasmussen, LB, Ovesen, L & Christiansen, E (1999) Day-to-day and within-day variation in urinary excretion. European Journal of Clinical Nutrition 53, 401407.Google Scholar
Reinli, K & Block, G (1996) Phytoestrogen content of foods – a compendium of literature values. Nutrition and Cancer 26, 123148.CrossRefGoogle Scholar
Riboli, E (1992) Nutrition and cancer, background and rationale of the European Prospective Investigation into Cancer and Nutrition (EPIC). Annals of Oncology 3, 783791.CrossRefGoogle ScholarPubMed
Riboli, E, Slimani, N & Kaaks, R (1996) Identifiability of food components for cancer chemoprevention Principles of Chemoprevention. In principle of Chemoprevention, pp. 2331 [Stewart, BW, McGregor, D and Kleihues, P, editors.] IARC Scientific Publications, no. 139, Lyon: IARC.Google Scholar
Rush, D (1994) Periconceptional folate and neural tube defects. American Journal of Clinical Nutrition 59(suppl), 511s516s.Google Scholar
Seow, A, Shi, CY, Franke, AA, Hankin, JH, Lee, HP & Yu, MC (1998) Isoflavonoid levels in spot urine are associated with frequency of dietary soy intake in a population-based sample of middle-aged and older Chinese in Singapore.. Cancer Epidemiology Biomarkers and Prevention 7, 135140.Google Scholar
Setchell, KDR (1998) Phytoestrogens, the biochemistry, physiology, and implications for human health of soy isoflavones. American Journal of Clinical Nutrition 68, 1333s1346s.Google ScholarPubMed
Shane, B (1995) Folate chemistry and metabolism. In Folate in Health and Disease, pp.122 [Bailey, LB, editor]. New York: Marcel Dekker.Google Scholar
Sinha, R, Rothman, N, Mark, SD, Murray, S, Brown, ED, Levander, OA, Davies, DS, Lang, NP, Kadlubar, FF & Hoover, RN (1995) Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity. Carcinogenesis 16, 28592861.Google Scholar
Slattery, ML & Janerich, DT (1991) The epidemiology of neural tube defects. A review of dietary intake and related factors as etiologic agents. American Journal of Epidemiology 133, 526540.Google Scholar
Slavin, JL, Karr, SC, Hutchins, AM & Lampe, JW (1998) Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion. American Journal of Clinical Nutrition 68(supp l), 1492s1495s.CrossRefGoogle ScholarPubMed
Smithells, RW, Nevin, NC, Seller, MJ, Sheppard, S, Harris, R, Read, AP, Fielding, DW, Walker, S, Schorah, CJ & Wild, CJ (1983) Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet i, 10271031.Google Scholar
Smithells, RW, Sheppard, S & Schorah, CJ (1976) Vitamin deficiencies and neural tube defects. Archives of Disease in Childhood 51(12), 944950.Google Scholar
Smithells, RW, Sheppard, S, Schorah, CJ, Seller, MJ, Nevin, NC, Harris, R, Read, AP & Fielding, DW (1980) Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet i, 339340.CrossRefGoogle Scholar
Stahl, W & Sies, H (1992) Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. Journal of Nutrition 122, 21612166.Google Scholar
Stansbury, JB, (1988) Iodine. In Modern Nutrition in Health and Disease, pp. 227237 [Shils, ME and Young, VR, editors] Philadelphia: lea and Febgier.Google Scholar
Stellman, SD, Djordjevic, MV, Muscat, JE, Gong, L, Bernstein, D, Citron, ML, White, A, Kemeny, M, Busch, E & Nafziger, AN (1998) Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York. Cancer Epidemiology Biomarkers and Prevention 7, 489496.Google ScholarPubMed
Stites, TE, Bailey, LB, Scott, KC, Toth, JP, Fisher, WP & Gregory, JF (1997) Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. American Journal of Clinical Nutrition 65, 5360.Google Scholar
Su, L-CJ, Bui, M, Kardinaal, A, Gomez-Aracena, J, Martin-Moreno, J, Martin, B, Thamm, M, Simonsen, N, van’t Veer, P, Kok, F, Strain, S & Kohlmeier, L (1998) Differences between plasma and adipose tissue biomarkers of carotenoids and tocopherols. Cancer Epidemiology Biomarkers and Prevention 7, 10431048.Google ScholarPubMed
Taylor, JA, Hirvonen, A, Watson, M, Pittman, G, Mohler, JL & Bell, DA (1996) Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Research 56, 41084110.Google Scholar
Tham, DM, Garder, CD & Haskell, WL (1998) Potential health benefits of dietary phytoestrogens. A review of the clinical, epidemiological, and mechanistic evidence. Journal of Clinical and Endocrine Metabolism 83, 22232235.Google Scholar
Thomson, CD, Colls, AJ, Conaglen, JV, Macormack, M, Stiles, M & Mann, J (1997) Iodine status of New Zealand residents as assessed by urinary iodine excretion and thyroid hormones. British Journal of Nutrition 78, 901912.Google Scholar
Thomson, CD, Smith, TE, Butler, KA & Packer, MA (1996) An evaluation of urinary measures of iodine and selenium status. Journal of Trace Elements in Medicine and Biology 10, 214222.CrossRefGoogle ScholarPubMed
Totsuka, Y, Fukutome, K, Takahashi, M, Takahashi, S, Tada, A, Sugimura, T & Wakabayashi, K (1996) Presence of N2-(dG-C8-MelQx) in human tissues. Carcinogenesis 17, 10291034.CrossRefGoogle ScholarPubMed
Ward, M, McNulty, H, McPartlin, J, Strain, JJ, Weir, DG & Scott, JM (1997) Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. Quarterly Journal of Medicine 90, 519524.CrossRefGoogle ScholarPubMed
Watanabe, S, Yamaguchi, M, Sobue, T, Takahashi, T, Miura, T, Arai, Y, Mazur, W, Wäjälä, K & Adlercreutz, H (1998) Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g braked soybean powder (Kinako). Journal of Nutrition 128, 17101715.Google Scholar
WCRF/AICR (World Cancer Research Fund and American Institute for Cancer Research) (1997) >Food, Nutrition and the Prevention of Cancer, a Global Perspective. Washington, DC: American Institute for Cancer Research.Food,+Nutrition+and+the+Prevention+of+Cancer,+a+Global+Perspective.+Washington,+DC:+American+Institute+for+Cancer+Research.>Google Scholar
Werler, MM, Shapiro, S & Mitchell, AA (1993) Periconceptional folic acid exposure and risk of occurrent neural tube defects. Journal of the American Medical Association 269, 12571261.Google Scholar
Westgard, JO, Peterson, PH & Wiebe, DA (1991) Laboratory process specifications for assuring quality in the US National Cholesterol Education Program. Clinical Chemistry 37(5), 656661.CrossRefGoogle ScholarPubMed
Wild, CP & Pisani, P (1997) Carcinogen–DNA and carcinogen–protein adducts in molecular epidemiology, IARC Scientific Publication No. 142. In Applications of Biomarkers in Cancer Epidemiology, pp. 143158.[Toniola, P, Boffetta, P, Shuker, DEG, Rothman, N, Hulka, B and Pearce, N, editors]. Lyon, France: International Agency for Research on Cancer.Google Scholar
Wild, CP, Hudson, GJ, Sabbioni, G, Chapot, B, Hall, AJ, Wogan, GN, Whittle, H, Montesano, R & Groopman, JD (1992) Dietary intake of aflatoxins and the level of albumin bound aflatoxin in peripheral blood in The Gambia, West Africa. Cancer Epidemiology Biomarkers and Prevention 1, 229234.Google Scholar
Xu, X, Harris, KS, Wang, H-J, Murphy, PA & Hendrich, S (1995) Bioavailability of soybean isoflavones depends upon gut microflora in women. Journal of Nutrition 125, 23072315.CrossRefGoogle ScholarPubMed
Xu, X, Wang, H-J, Murphy, PA, Cook, L & Hendrich, S (1994) Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. Journal of Nutrition 124, 825832.Google Scholar
Yadollahi-Farsani, M, Gooderham, NJ, Davies, DS & Boobis, AR (1996) Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(phip) at the Chinese hamsters hprt locus. Carcinogenesis 17, 617624.Google Scholar
Yu, MC, Ho, JHC, Lai, SH & Henderson, BE (1986) Cantonese style salted fish as a cause of nasopharyngeal carcinoma, report of a case-control study in Hong Kong. Cancer Research 46, 956961.Google Scholar
Zeleniuch-Jacquotte, A, Adlercreutz, H, Akhmedkhanov, A & Toniolo, P (1998) Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two-year period. Cancer Epidemiology Biomarkers and Prevention 7, 885889.Google Scholar
Zhang, Y, Wang, G-J, Song, TT, Murphy, PA & Hendrich, S (1999) Urinary disposition of soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity. Journal of Nutrition 129, 957962.Google Scholar