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A comparison of the effects of soya-bean protein and casein on bile composition, cholelithiasis and serum lipoprotein lipids in the vervet monkey (Cercopithecus aethiops)

Published online by Cambridge University Press:  09 March 2007

K. Jaskiewicz ,
M. J. Weight ,
K. J. Christopher ,
A. J. S. Benadé  and
D. Kritchevsky
K. Jaskiewicz
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
M. J. Weight
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
K. J. Christopher
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
A. J. S. Benadé
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
D. Kritchevsky
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
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Abstract

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1. Two groups of vervet monkeys (Cercopithecus uethiops) were fed on high-cholesterol diets which differed only with respect to the protein source. In one group casein was the only protein source, while the other group received only soya-bean protein.

2. Samples of blood, bile and liver biopsy material were collected at the commencement of the study and at 3-monthly intervals until termination 12 months later.

3. At the end of the experimental period all the animals (n 19) had high plasma cholesterol levels and had developed pigment gallstones, the compositions and weights of which were not related to the protein source or to plasma cholesterol levels. Gallstone weight was related to the presence of acidic and sulphated mucins in gallbladder mucosa. We were also unable to confirm the hypocholesterolaemic effect of soya-bean protein which has been demonstrated previously in rhesus monkeys and hamsters. Bile composition, and plasma lipids did not differ significantly between the casein-fed and soya-bean fed animals. Lithogenic index was below 1 for both groups and did not differ significantly between the two groups.

4. No significant difference was found in the severity ofcholelithiasis between the casein-fed and the soya-bean-fed animals.

Type
Clinical and Human Nutrition papers: Other Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 58 , Issue 2 , September 1987 , pp. 257 - 263
Copyright
Copyright © The Nutrition Society 1987

References

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