Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-25T05:16:33.100Z Has data issue: false hasContentIssue false
  • English
  • Français

A comparison of the effects of soya-bean protein and casein on bile composition, cholelithiasis and serum lipoprotein lipids in the vervet monkey (Cercopithecus aethiops)

Published online by Cambridge University Press:  09 March 2007

K. Jaskiewicz ,
M. J. Weight ,
K. J. Christopher ,
A. J. S. Benadé  and
D. Kritchevsky
K. Jaskiewicz
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
M. J. Weight
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
K. J. Christopher
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
A. J. S. Benadé
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
D. Kritchevsky
Affiliation:
Research Institute for Nutritional Diseases of the South African Medical Research Council, PO Box 70, Tygerberg 7505, South Africa
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Two groups of vervet monkeys (Cercopithecus uethiops) were fed on high-cholesterol diets which differed only with respect to the protein source. In one group casein was the only protein source, while the other group received only soya-bean protein.

2. Samples of blood, bile and liver biopsy material were collected at the commencement of the study and at 3-monthly intervals until termination 12 months later.

3. At the end of the experimental period all the animals (n 19) had high plasma cholesterol levels and had developed pigment gallstones, the compositions and weights of which were not related to the protein source or to plasma cholesterol levels. Gallstone weight was related to the presence of acidic and sulphated mucins in gallbladder mucosa. We were also unable to confirm the hypocholesterolaemic effect of soya-bean protein which has been demonstrated previously in rhesus monkeys and hamsters. Bile composition, and plasma lipids did not differ significantly between the casein-fed and soya-bean fed animals. Lithogenic index was below 1 for both groups and did not differ significantly between the two groups.

4. No significant difference was found in the severity ofcholelithiasis between the casein-fed and the soya-bean-fed animals.

Type
Clinical and Human Nutrition papers: Other Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 58 , Issue 2 , September 1987 , pp. 257 - 263
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Bennion, L. J. & Grundy, S. N. (1978). New England Journal of Medicine 299, 1161–1167.CrossRefGoogle Scholar
Bolton, C. H., Low-Beer, T. S., Pomare, E. W., Wicks, A. C. B., Yeates, J. & Heaton, K. W. (1978). Clinica Chimica Acta 83, 177–181.CrossRefGoogle Scholar
Bruusgaard, A., Sorensen, H., Gilhuus-Moe, C. C. & Skalhegg, B. A. (1977). Clinica Chimica Acta 77, 387–395.CrossRefGoogle Scholar
Dreyer, J. J. & Du Bruyn, D. B. (1968). South African Medical Journal 42, 600–604.Google Scholar
Holzbach, R. T. (1984). Hepatology 4, 1915–1985.Google Scholar
Itaya, K. & Ui, M. (1966). Clinica Chimica Acta 14, 361–366.CrossRefGoogle Scholar
Izumi, K. (1965). Fukuoka Acta Medica 56, 488–523.Google Scholar
Kameda, H. (1964). Gastroenterology 46, 109–114.CrossRefGoogle Scholar
Kritchevsky, D. & Klurfeld, D. (1979). American Journal of Clinical Nutrition 32, 2174–2176.CrossRefGoogle Scholar
Kritchevsky, D. & Klurfeld, D. (1983). American Journal of Clinical Nutrition 37, 802–804.CrossRefGoogle Scholar
La Morte, W. W., Matolo, N. M., Birkett, D. H. & Williams, L. F. Jr (1981). Surgical Clinics of North America 61, 765–774.CrossRefGoogle Scholar
Mahfouz-Cercone, S., Johnson, J. E. & Liepa, G. J. (1984). Lipids 19, 5–10.CrossRefGoogle Scholar
Maki, T., Matsushiro, T. & Suzuki, N. (1971). Surgery, Gynecology and Obstetrics 132, 846–851.Google Scholar
Malet, P. F., Deng, S. Q., Locke, C. L. & Soloway, R. D. (1986). Gastroenterology 90, 1744–1794.Google Scholar
Metzger, A. L., Heymsfield, S. & Grundy, S. M. (1972). Gastroenterology 62, 499–501.CrossRefGoogle Scholar
Nagashima, H., Suzuki, N. & Yosizawa, Z. (1974). Tohoku Journal of Experimental Medicine 113, 159–168CrossRefGoogle Scholar
Osuga, T. & Portman, O. W. (1971). Proceedings of the Society of Experimental Biology and Medicine 136, 722–726.CrossRefGoogle Scholar
Osuga, T., Portman, O. W., Mitamura, K. & Alexander, M. (1974). Laboratory Investigation 30, 486–493.Google Scholar
Smith, B. F. & LaMont, J. J. (1984). Hospital Practice 93–104.CrossRefGoogle Scholar
Soloway, R. D., Trotman, B. W. & Ostrow, J. D. (1977). Gastroenterology 72, 167–182.CrossRefGoogle Scholar
StClair, R. W., Henderson, G. R., Heaster, V., Vagner, W. D., Bond, M. G. & McMahan, M. R. (1980). Atherosclerosis 37, 103–121.CrossRefGoogle Scholar
Sullivan, M. A., Duffy, A., Dimarco, N. & Liepa, G. (1985). Lipids 20, 1–6.CrossRefGoogle ScholarPubMed
Terpstra, A. H. M., West, C. E., Fennis, J. C. M., Schouten, J. A. & Van der Veen, E. A. (1984). American Journal of Clinical Nutrition 39, 1–7.CrossRefGoogle Scholar
Thomas, P. J. & Hofman, A. F. (1973). Gastroenterology 65, 698–700.CrossRefGoogle Scholar
Trotman, B. W., Ostrow, J. D. & Soloway, R. D. (1974). American Journal of Digestive Diseases 19, 585–590.CrossRefGoogle Scholar
Yagi, T. (1960). Tohoku Journal of Experimental Medicine 72, 117–130.CrossRefGoogle Scholar