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Changes in bioavailability and tissue distribution of zinc caused by magnesium deficiency in rats

Published online by Cambridge University Press:  09 March 2007

Elena Planells ,
Pilar Aranda ,
Ana Lerma  and
Juan Llopis
Elena Planells
Affiliation:
Institute of Nutrition and Food Technology, University of Granada, E-18071 Grunada, Spain
Pilar Aranda
Affiliation:
Institute of Nutrition and Food Technology, University of Granada, E-18071 Grunada, Spain
Ana Lerma
Affiliation:
Department of Physiology, University of Granada, E-18071 Grunada, Spain
Juan Llopis
Affiliation:
Institute of Nutrition and Food Technology, University of Granada, E-18071 Grunada, Spain
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Abstract

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The effect of a Mg-deficient diet (200 mg Mg/kg feed) on the bioavailability of dietary Zn and the concentration of this cation in plasma, whole blood, skeletal muscle, kidney, heart and brain of Wistar rats was studied after 7, 35, 42, 49, 56, 63 and 70 d. Mg deficiency significantly decreased Zn in whole blood on day 42 of the experiment, but there was no significant change in plasma Zn throughout the 70 d study period. The Mg-deficient diet significantly increased intestinal absorption of Zn, Zn balance, and Zn concentration in femur and kidney, but decreased Zn concentration in the heart despite the increase in dry weight of this organ. No change was found in brain Zn concentration.

Keywords

MagnesiumZincRat
Type
Effects of magnesium deficiency on zinc bioavailability
Information
British Journal of Nutrition , Volume 72 , Issue 2 , August 1994 , pp. 315 - 323
Copyright
Copyright © The Nutrition Society 1994

References

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